Newest studies

The social construction of Aduhelm in the context of pharmaceutical ambiguity: exploring narratives from informal caregivers, medical professionals, and redditors on r/Alzheimers

28/100 ✓ Peer-reviewed Drug development Frontiers in Sociology

Key finding: Our findings reveal various concerns about Aduhelm involving efficacy, safety, and affordability. +3 more findings

• Treatments

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TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia

48/100 ✓ Peer-reviewed Lewy body dementia PLoS Biology

Key finding: To investigate whether TDP-43-mediated APA events occur in the postmortem brain, we measured the 3' untranslated region length of the retromer component vacuolar protein sorting 35 (VPS35) and the ETS transcription factor (ELK1) in the frontal cortex of a large cohort of FTLD-TDP patients and of healthy controls, and evaluated if these APA events are associated with FTLD-TDP clinical characteristic, markers of TDP-43 pathology [e.g., hyperphosphorylated TDP-43 and cryptic stathmin-2 RNA], or the expression of VPS35 and VPS29 proteins, the latter being essential to the retromer complex. +3 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model

42/100 ✓ Peer-reviewed Lewy body dementia Journal of Biomedical Science

Key finding: AD patients exhibited increased expression of pyroptosis-related genes, supporting the involvement of pyroptosis in neurodegeneration. +4 more findings

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

The role of artificial intelligence in hypertension management

41/100 ✓ Peer-reviewed Digital health tools Current Opinion in Nephrology & Hypertension

Key finding: Hypertension remains a leading modifiable risk factor for cardiovascular and renal conditions and dementia. +4 more findings

• Digital Tools
• Risk Factors

Full summary, score breakdown and related studies → Original source

Community perceptions and barriers to brain health and dementia care in rural communities in Cameroon: a qualitative study

34/100 ✓ Peer-reviewed Disparities BMC Neurology

Key finding: The study included seven healthcare workers, five participants with dementia and their caregivers, and 10 persons without dementia. +4 more findings

• Health Equity

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Propyl Gallate Attenuates Methylglyoxal-Induced Alzheimer-like Cognitive Deficits and Neuroinflammation in Mice

42/100 ✓ Peer-reviewed Inflammation and the immune system International Journal of Molecular Sciences

Key finding: Methylglyoxal (MG), a reactive dicarbonyl metabolite associated with diabetes and metabolic disorders, contributes to carbonyl stress, neuroinflammation, and Alzheimer-like neurodegeneration. +3 more findings

• Brain Biology

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Roles of Reactive Oxygen Species in Relationships Between Viral Infections and Alzheimer’s Disease and Related Dementia

42/100 ✓ Peer-reviewed Disease mechanisms Antioxidants

Key finding: Emerging evidence suggests that viral infections may contribute to the onset and progression of Alzheimer's disease (AD) and other forms of dementia. +3 more findings

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Gut Microbiome–Sphingolipid Metabolism–Brain Axis Interactions: Neuroprotective Effects of Amitriptyline as Functional Inhibitor of Acid Sphingomyelinase in a Mouse Model of Tauopathy

37/100 ✓ Peer-reviewed Disease mechanisms Journal of Neuroimmune Pharmacology

Key finding: AMI treatment significantly reduced colonic ASM, ceramide levels, increased abundance of Harryflintia, Dubosiella, and Parasutterella and decreased abundance of Lactobacillus, Lachnoclostridium, Oscillibacter, Oscillospiracea UCG-003, Colidextribacter, Roseburia, Butyricicoccus, and Sphingomondales. +2 more findings

• Brain Biology

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Nose to Brain Delivery of Curcumin Loaded Therapeutic Nanostructures for Neurodegenerative Diseases

31/100 ✓ Peer-reviewed Treatments Biopharmaceutics & Drug Disposition

Key finding: As nanotechnology continues to improve, research on the delivery of drug through intranasal route has grown significantly in last 10 years.

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Plasma lipid subspecies and Alzheimer’s disease: genetic evidence for risk and protection

37/100 ✓ Peer-reviewed Genetics QJM

Key finding: MR analysis identified phosphatidylinositol (PI) (16:0_20:4), phosphatidylcholine (PC) (16:0_22:4) and sterol ester (SE) (27:1/15:0) as risk factors for AD. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Effects of digital psychological interventions for family caregivers of people with dementia: a systematic review and meta-analysis

57/100 ✓ Peer-reviewed Caregiving Age and ageing

Key finding: Future studies should prioritize short-term interventions and develop integrated approaches combining individual and group formats. +1 more finding

• Caregiving
• Digital Tools

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Brain health navigation in a large integrated healthcare system

35/100 ✓ Peer-reviewed Health systems and care delivery The journal of prevention of Alzheimer's disease

Key finding: We have experienced no significant barriers to reimbursement and when accounting for incremental downstream revenue generation (e.g.

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Relative validity of an online short FFQ assessing the Dutch adapted version of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet in older adults at risk of cognitive decline

37/100 ✓ Peer-reviewed Prevention trials British Journal Of Nutrition

Key finding: The average MIND-NL scores for the short FFQ (8·4 ( sd 1·8) points) and food records (6·7 ( sd 1·7) points) showed to be significantly different ( P 0·20) were observed for 10 out of 15 MIND-NL diet components. +1 more finding

• Lifestyle
• Digital Tools

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Primary Care Physician Perspectives on Artificial Intelligence for Dementia Screening: A Qualitative Study

33/100 ✓ Peer-reviewed Digital health tools AJOB Empirical Bioethics

Key finding: Participants reported routine screening for cognitive impairment only in the context of the Medicare annual wellness visit and generally avoided routine screening because of limited treatment options to support patients, such as poor access to geriatrics/neuropsychiatric services. +4 more findings

• Digital Tools
• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Neuropathologic Profiles and Associated Cognitive Trajectories in Community-Living Older Adults

55/100 ✓ Peer-reviewed Laboratory science JAMA Network Open

Key finding: Latent neuropathologic profiles were identified using hierarchical clustering, and longitudinal cognitive trajectories associated with each profile were estimated using functional mixed-effects models. +3 more findings

• Brain Biology

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Small-Sized Reasoning Language Models for Linguistic Screening of Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: This work examines artificial intelligence (AI) methods for assessing cognitive status from linguistic features. +4 more findings

• Diagnosis
• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The microbiota-gut-brain axis in mild cognitive impairment and Alzheimer's disease: a scoping review of human studies

77/100 ✓ Peer-reviewed Disease mechanisms Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Our results demonstrated that gut dysbiosis was frequently reported in MCI and AD, including increased Pseudomonadota and Actinomycetota in AD and reduced diversity in some cases.

• Early Stage

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Defining patient-centered amyloid PET thresholds for the onset of tauopathy in Alzheimer's disease

57/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We found a consistent amyloid PET × age interaction on global tau PET increase in men (ADNI/A05: p = 0.0078/0.018), with younger men showing faster amyloid-associated tau accumulation. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Biological age acceleration associates with Alzheimer's disease plasma biomarker levels

52/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Age acceleration was significantly associated with sex, clinical diagnosis, and levels of eight plasma biomarkers, including P-tau217 levels. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Plasma Aβ42/40 predicts progression from Aβ-amyloid negative to positive PET scans

66/100 ✓ Peer-reviewed Biomarkers The journal of prevention of Alzheimer's disease

Key finding: At baseline, 283 were Plasma-/PET-, 97 Plasma+/PET-, 76 Plasma-/PETLow, and 51 Plasma+/PETLow. +4 more findings

• Biomarkers
• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Association of plasma p-tau and p-tau/Aβ ratio with Alzheimer's pathology

70/100 ✓ Peer-reviewed Biomarkers The journal of prevention of Alzheimer's disease

Key finding: Among the individual plasma p-tau variants, p-tau217 consistently outperformed p-tau181 and p-tau231. +3 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Vagus Nerve Stimulation in the Management of Neurodegenerative Diseases: A Systematic Review of Advances in Animal Research and Clinical Applications

51/100 ✓ Peer-reviewed Inflammation and the immune system Current Alzheimer research

Key finding: Vagus Nerve Stimulation (VNS) shows neuroprotective and anti-inflammatory effects in animal models of Alzheimer's and Parkinson's disease, but clinical results remain inconsistent due to variability in treatment duration, outcome measures, and reliance on subjective assessments. +4 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Artificial Intelligence in Medicare and Medicaid: A Review of Clinical Decision Support, Fraud Detection, Prior Authorization, and Healthcare Utilization

15/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery Not indexed

Key finding: The literature shows that machine-learning models can identify patterns associated with cognitive impairment, falls, acutecare use, emergency-department visits, elder mistreatment, and healthcare spending.

• Policy
• Digital Tools

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Health System Integration and Prior Authorization in Medicare Advantage

40/100 ✓ Peer-reviewed Health systems and care delivery Health Services Research

Key finding: System affiliation is associated with less restrictive PA policies in MA, highlighting organizational structure as an important dimension of utilization management. +2 more findings

• Care Services
• Policy

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The Impact of Store-Based online Fulfilment on Grocery Retail Food Waste: An Empirical Analysis

15/100 ⚠ Preprint — not yet peer-reviewed Risk factors Not indexed

Key finding: Our study provides the first causal estimate of this impact and traces the operational levers behind it.  <br><br>Methodology/results:Exploiting the staggered roll-out of store-basd online fulfilment at a European grocer, we apply difference-indifferences estimators to a 48-mont +2 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source