Newest studies

The dementia care workforce: Essential to care but large research gaps exist

47/100 ✓ Peer-reviewed Caregiving Alzheimer s & Dementia

Key finding: There are many opportunities for new research to help direct care workers meaningfully contribute to the health and well-being of people living with dementia and their care partners. +4 more findings

• Caregiving

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Assessment of Plasma and Cerebrospinal Fluid Biomarkers in Patients with Alzheimer’s Disease and Other Dementias: A Center-Based Study

48/100 ✓ Peer-reviewed Getting a diagnosis International Journal of Molecular Sciences

Key finding: The results showed significant positive correlations between CSF and plasma levels of Aβ42, the Aβ42/Aβ40 ratio, and pTau181, but not for Aβ40. +2 more findings

• Biomarkers
• Diagnosis

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Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial

58/100 ✓ Peer-reviewed Prevention and risk Alzheimer s & Dementia

Key finding: Among ACHIEVE participants in the top quartile of predicted risk, 3-year cognitive decline in the hearing intervention was 61.6% (95% confidence interval [CI]: 33.7%-94.1%) slower than the control. +4 more findings

• Clinical Trials

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The ethical allocation of dementia prevention responsibility

39/100 ✓ Peer-reviewed Prevention and risk The Lancet Healthy Longevity

Key finding: Health campaigns on dementia can not only enable equity and promote systemic health improvements but also reinforce the stigma associated with the disease or attribute moral culpability to the affected populations.

• Prevention

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An Assessment of Nature-Based Solutions Water Infrastructure for Flood Risk Reduction in Unplanned Area

37/100 ✓ Peer-reviewed Prevention and risk Civil Engineering Journal

Key finding: This study aimed to investigate the effectiveness of the Brigif Reservoir as a pioneering nature-based infrastructure solution for mitigating flood risk in the Kemang area, a significant business district in South Jakarta, and to provide a potential raw water supply for city parks. +3 more findings

• Prevention

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Anti-Amyloid-Antikörper: Ein Meilenstein in der Behandlung der Alzheimer-Krankheit: Pro

30/100 ✓ Peer-reviewed Treatments Psychiatrische Praxis

Key finding: Die Therapie wird in Abhängigkeit von der Größe der Veränderungen und dem Auftreten hierdurch bedingter Symptome gegebenenfalls unterbrochen. +4 more findings

• Treatments

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Anti-Amyloid-Antikörper: Ein Meilenstein in der Behandlung der Alzheimer-Krankheit: Kontra

29/100 ✓ Peer-reviewed Treatments Psychiatrische Praxis

Key finding: Dürfen Medikamente mit minimaler Wirkung und im Einzelfall schweren Nebenwirkungen (auf die hier aus Platzgründen nicht weiter eingegangen wird), den PatientInnen, die sich ja auch große Hoffnungen machen, zugemutet werden? +4 more findings

• Treatments

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Regional variability of the impact of cardiometabolic diseases on incident dementia in United States Medicare beneficiaries

44/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: The nationwide combined weighted PAF for the eight CMDs was 37% overall, with hypertension (9.6%), ischemic heart disease (6.7%), and chronic heart failure (5.7%) associated with the greatest attributable fractions of dementia cases. +4 more findings

• Risk Factors

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Cardioprotective Glucose-Lowering Agents and Dementia Risk: A Systematic Review and Meta-Analysis

74/100 ✓ Peer-reviewed Treatments JAMA neurology

Key finding: Twenty-six randomized clinical trials were eligible for inclusion (N = 164 531 participants), of which 23 trials (n = 160 191 participants) reported the incidence of dementia or cognitive impairment, including 12 trials evaluating SGLT2is, 10 trials evaluating GLP-1RAs, and 1 trial evaluating pioglitazone (no trials of metformin were identified). +4 more findings

• Treatments
• Risk Factors
• Clinical Trials

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Analytical Validation and Performance of a Blood-Based P-tau217 Diagnostic Test for Alzheimer Disease

43/100 ✓ Peer-reviewed Biomarkers The journal of applied laboratory medicine

Key finding: Through analytical validation, this assay demonstrated robust performance across multiple lots, operators, and instruments and could be used as a tool for diagnosing AD. +4 more findings

• Biomarkers
• Diagnosis

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Cerebral Amyloid Angiopathy and Downstream Alzheimer Disease Plasma Biomarkers

62/100 ✓ Peer-reviewed Biomarkers JAMA network open

Key finding: Lobar CMB counts and the presence of CAA were associated with downstream AD plasma biomarkers, including p-tau217 (β = 0.12 [95% CI, 0.05-0.18] and 0.29 [95% CI, 0.12-0.47], respectively), GFAP (β = 0.07 [95% CI, 0.03-0.12] and 0.20 [95% CI, 0.09-0.31], respectively), and NfL (β = 0.07 [95% CI, 0.03-0.11] and 0.16 [95% CI, 0.06-0.25], respectively) with and without the mediation of Aβ uptake on PET (indirect effect: lobar CMBs-p-tau217, 59.8% [β = 0.07 (95% CI, 0.03-0.11)]; lobar CMBs-GFAP, 49.3% [β = 0.04 (95% CI, 0.01-0.06)]; lobar CMBs-NfL, 20.9% [β = 0.01 (95% CI, 0.01-0.03)]; CAA-p-tau217, 50.9% [β = 0.15 (95% CI, 0.06-0.24)]; CAA-GFAP, 39.2% [β = 0.08 (95% CI, 0.03-0.13)]; CAA-NfL, 19.2% [β = 0.03 (95% CI, 0.01-0.05)]). +3 more findings

• Biomarkers
• Brain Scans

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Cognitive Phenotyping and Interpretation of Alzheimer Blood Biomarkers

70/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: However, the importance of detailed cognitive phenotyping in patients without dementia when interpreting p-tau217 results remains unclear. +3 more findings

• Biomarkers

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Referral Criteria for Specialist Palliative Care for Patients With Dementia

56/100 ✓ Peer-reviewed Caregiving JAMA Network Open

Key finding: In this Delphi survey study, international experts reached consensus on a range of criteria for referral to specialist palliative care.

• End-of-Life Care

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Amyloid-Related Imaging Abnormalities With Donanemab in Early Symptomatic Alzheimer Disease: Secondary Analysis of the TRAILBLAZER-ALZ and ALZ 2 Randomized Clinical Trials

83/100 ✓ Peer-reviewed Treatments JAMA Neurology

Key finding: ARIA is an adverse event associated with donanemab treatment that requires safety monitoring. +3 more findings

• Clinical Trials
• Treatments
• Side Effects

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Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders

43/100 ✓ Peer-reviewed TREM2 and immune genetics Science translational medicine

Key finding: Overall, our study introduces TCMDT as a practical, efficient, and safe approach for microglia replacement, suggesting therapeutic potential for treating neurological disorders associated with microglial dysfunction.

• Brain Biology
• Genetics

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Approach to Patients with Dysphagia: Clinical Insights

37/100 ✓ Peer-reviewed Clinical safety Brain Sciences

Key finding: Oropharyngeal dysphagia frequently occurs in central nervous system diseases such as stroke, dementia, and Parkinson's disease and has a significant impact on prognosis. +1 more finding

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Perceived Control, Cognitive Training, and Incident Alzheimer’s Disease and Related Dementias in the ACTIVE Study

42/100 ✓ Peer-reviewed Prevention trials The Journals of Gerontology Series B

Key finding: Greater perceived control at study baseline was associated with reduced hazard of ADRD. +2 more findings

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Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology

40/100 ✓ Peer-reviewed Inflammation and the immune system Glia

Key finding: Alteration in synaptic transmission in males coincides with an increased number and coverage of microglia, together with increased plaque coverage, as compared to the female hippocampus.

• Brain Biology

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Can the herpes zoster vaccination be a strategy against dementia?

48/100 ✓ Peer-reviewed Inflammation and the immune system Drug Discoveries & Therapeutics

Key finding: Epidemiological evidence indicates that HZ infection, especially in individuals with central nervous system involvement, may increase the risk of dementia. +1 more finding

• Prevention
• Brain Biology

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Seasonal and daily variation in indoor light and temperature are associated with sleep disturbance in dementia

44/100 ✓ Peer-reviewed Risk factors SLEEP

Key finding: Beyond the effects of season, higher bedroom temperature and less bright indoor daytime light are associated with more disrupted sleep and higher respiratory rate.

• Lifestyle

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Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort

55/100 ✓ Peer-reviewed How common it is Scientific Reports

Key finding: This cross-sectional study clustered and characterized a U.S. cohort's knowledge and practice of healthy behavior associated with dementia and stroke. +2 more findings

• Prevention
• Lifestyle

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ROLE OF RADIO DIAGNOSIS IN EARLY DETECTION OF ALZHEIMERS DISEASE:A SYSTEMATIC REVIEW

44/100 ✓ Peer-reviewed Brain scans and imaging International Journal of Advanced Research

Key finding: Alzheimers disease (AD) represents the most prevalent form of dementia, affecting millions worldwide and posing significant public health challenges. +1 more finding

• Diagnosis
• Brain Scans
• Early Stage

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Komparasi Performa Model 3D CNN dalam Klasifikasi Demensia Alzheimer pada MRI Otak

26/100 ✓ Peer-reviewed Brain scans and imaging IJEIS (Indonesian Journal of Electronics and Instrumentation Systems)

Key finding: Dataset yang digunakan diperoleh dari database ADNI. +4 more findings

• Brain Scans

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Optimized Neural Network Architectures for Early Detection of Alzheimer\'s disease Using MRI Images

28/100 ✓ Peer-reviewed Brain scans and imaging International Journal for Research in Applied Science and Engineering Technology

Key finding: Throu gh quantization, we achieve significant model size reduction (75-77%) while maintaining high classification accuracy. +1 more finding

• Diagnosis
• Brain Scans
• Digital Tools

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Using Machine Learning to Predict Cognitive Decline in Older Adults From the Chinese Longitudinal Healthy Longevity Survey: Model Development and Validation Study

57/100 ✓ Peer-reviewed Biomarkers JMIR Aging

Key finding: All ML models outperformed the MMSE alone. +4 more findings

Full summary, score breakdown and related studies → Original source