Newest studies

Concordance Between Amyloid-PET Quantification and Real-World Visual Reads

63/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: Of 18 293 participants included in the parent study, scan images were available for 10 774 (59%), of which Centiloids were successfully calculated for 10 361 (96%).

Full summary, score breakdown and related studies → Original source

Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

76/100 ✓ Peer-reviewed Biomarkers The Lancet Neurology

Key finding: 113 studies, 29,625 participants included in bivariate meta-analysis +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Role of Monoclonal Antibodies in Alzheimer's Disease: Successes, Failures, and Future Directions

43/100 ✓ Peer-reviewed Treatments Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Key finding: Monoclonal antibodies (mAbs) are a new therapeutic approach targeting the specific biochemical abnormalities associated with AD. +1 more finding

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

NRF2 deficiency is associated with synaptic alterations and ether-linked phospholipid imbalance in the hippocampus

39/100 ✓ Peer-reviewed Disease mechanisms Redox Biology

Key finding: We assessed synaptic contacts both in vitro and in vivo and found that NRF2 deficiency leads to a significant reduction in vGLUT1 levels, accompanied by a decrease in the number of synaptic contacts. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

A biophysical and molecular characterization of the interaction between the Alzheimer risk factor BIN1 and the neuronal scaffold protein p140Cap

35/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Biological Chemistry

Key finding: Additional surface plasmon resonance experiments, coupled with alanine-scanning mutagenesis, revealed that two class II motifs, but not a class I motif, in p140Cap facilitated binding. +1 more finding

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Early Alzheimer’s disease (mild cognitive impairment or mild dementia): Prevalence, diagnostics, treatment options, and guidelines in Asia, Australasia, and Pacific nations countries

38/100 ✓ Peer-reviewed How common it is The Journal of Prevention of Alzheimer s Disease

Key finding: Published information regarding AD incidence and prevalence and current practice in AAPN countries is limited and the nature of available information differs between countries. +4 more findings

• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source

Gut Microbiota in Psychiatric and Neurological Disorders: Current Insights and Therapeutic Implications

43/100 ✓ Peer-reviewed Disease mechanisms Biomedicines

Key finding: Changes in the composition of the gut microbiota-dysbiosis-are associated with conditions such as depression, schizophrenia, bipolar disorder (BD), autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD), and neurodegenerative diseases such as Parkinson's and Alzheimer's.

• Treatments

Full summary, score breakdown and related studies → Original source

Peruvian validation and standardization of the TabCAT-brain health assessment

48/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in public health

Key finding: By incorporating sex, place of residence, age, and years of education as covariates, the TabCAT-BHA demonstrated greater accuracy in detecting cognitive impairment (AUC = 75.3%) compared to the MMSE (AUC = 66.4%) and RUDAS (AUC = 71.4%). +2 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Coverage and Prior Authorization Policies for Semaglutide and Tirzepatide in Medicare Part D Plans

44/100 ✓ Peer-reviewed Health systems and care delivery JAMA Network Open

Key finding: This cross-sectional study examines trends in coverage of glucagon-like peptide-1 receptor agonists, semaglutide and tirzepatide, and prior authorization requirements among Medicare Part D beneficiaries.

• Policy
• Treatments

Full summary, score breakdown and related studies → Original source

Constipation preceding stroke, dementia and Parkinson’s disease in middle-aged and older adults: a population-based cohort study

52/100 ✓ Peer-reviewed Vascular contributions Age and Ageing

Key finding: Out of 462,327 eligible participants, those with constipation were associated with higher incidence of three outcome diseases (1415/20,263 [7.0%]) than those without (18,848/442,064 [4.3%]), with adjusted hazard ratio (HR) being 1.35 [1.27-1.42]. +4 more findings

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Maintaining independence at home after a fall: a process evaluation of the MAINTAIN multicomponent intervention for people living with dementia

54/100 ✓ Peer-reviewed Clinical safety Age and Ageing

Key finding: The MAINTAIN intervention demonstrated high fidelity in home assessments and intervention delivery, with participants receiving a mean of 15 of the 22 available sessions with a range of 5-25 sessions. +4 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series

45/100 ✓ Peer-reviewed Clinical safety Age and Ageing

Key finding: The risk of delirium admissions was elevated for the first 1-30 days of prescriptions [IRR 1.54 (95% CI 1.30-1.82) for men, 1.44 (1.22-1.70) for women] and whilst reducing over time for women [1.10 (0.94-1.29) for 91-365 days of prescriptions], it remained elevated for men [1.38 (1.17-1.64)]. +4 more findings

• Treatments
• Care Services

Full summary, score breakdown and related studies → Original source

Delirium prevalence, diagnostic uncertainty and outcomes in ORCHARD-EPR: validation against prospective reference cohorts

47/100 ✓ Peer-reviewed Clinical safety Age and Ageing

Key finding: Among 18 614 ORCHARD-EPR patients (mean/SD age = 82.9/7.4 years, dementia = 20%), certain delirium (delirium = yes or ICD-10 delirium code) was present in 3077/18 614 (17%,95%CI 16%-17%) of whom 1199/3077 (39%) had dementia, and uncertain delirium (delirium = uncertain and no ICD-10 code) in 2007 (11%,10%-11%) of whom 773/2007 (39%) had dementia. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration

44/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Aging Neuroscience

Key finding: While significant strides have been made, gaps in knowledge persist, emphasizing the need for larger, more standardized studies.

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Research progress of multimodal biomarkers in the early diagnosis of mild cognitive impairment in Parkinson’s disease

38/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Neurology

Key finding: Early diagnosis of PD-MCI is crucial for the prognosis of the disease. +4 more findings

• Early Stage
• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Enhancing Alzheimer’s Diagnosis with Machine Learning on EEG: A Spectral Feature-Based Comparative Analysis

43/100 ✓ Peer-reviewed Digital health tools Diagnostics

Key finding: The SVM classifier achieved a notable accuracy of 96.01%, outperforming previously reported methods. +1 more finding

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Incidence of dementia among individuals 70 years and older in Norway: A HUNT study

52/100 ✓ Peer-reviewed How common it is Journal of Alzheimer s Disease

Key finding: Age-specific dementia incidence rates, standardized for the Norwegian population, were calculated as the number of new dementia cases per 1000 person-years assuming onset midway between study waves with inverse probability weights based on baseline factors associated with non-participation or death. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Global trends in Alzheimer’s disease and other dementias in adults aged 55 and above (1992–2021): An age-period-cohort analysis based on the GBD 2021

42/100 ✓ Peer-reviewed How common it is PLoS ONE

Key finding: From 1992 to 2021, ADOD incidence among individuals aged ≥55 increased by 143.88%. +4 more findings

Full summary, score breakdown and related studies → Original source

The Caribbean American Dementia and Aging Study: protocol for a population-based study of older adult health and dementia in Cuba, the Dominican Republic, and Puerto Rico

44/100 ✓ Peer-reviewed Getting a diagnosis BMC Geriatrics

Key finding: With this study, we will contribute nationally representative data on health, dementia and cognitive aging in Dominican Republic and Puerto Rico, as well as harmonized data in Cuba to expand understanding of aging and dementia in the Hispanic Caribbean and promote cross-national comparative research around the world.

Full summary, score breakdown and related studies → Original source

Diet and Prevention of Cardiovascular Disease and Cancer

41/100 ✓ Peer-reviewed Prevention and risk JACC CardioOncology

Key finding: Although the pathophysiology of CVD and cancer is complex and multifactorial, lifestyle factors including diet often contribute significantly to their pathogenesis.

• Risk Factors
• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Tirzepatide compared with semaglutide and 10-year cardiovascular disease risk reduction in obesity: post-hoc analysis of the SURMOUNT-5 trial

59/100 ✓ Peer-reviewed Prevention and risk European Heart Journal Open

Key finding: In SURMOUNT-5, treatment with tirzepatide was associated with greater predicted 10-year CVD risk reduction compared with semaglutide. +2 more findings

• Clinical Trials
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Lifestyle and Breast Cancer: Prevention and Treatment Support

38/100 ✓ Peer-reviewed Prevention and risk Cancers

Key finding: It is a significant health and social issue affecting 2.3 million women worldwide.

• Prevention
• Lifestyle
• Treatments

Full summary, score breakdown and related studies → Original source

Diagnosis of Alzheimer’s disease using biological markers in corticobasal syndrome

28/100 ✓ Peer-reviewed Treatments S S Korsakov Journal of Neurology and Psychiatry

Key finding: Most often, CBS is associated with corticobasal degeneration (CBD) or Alzheimer’s disease (AD). +2 more findings

• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Causal effect of infectious mononucleosis on neurodegenerative diseases: A Mendelian randomization study

37/100 ✓ Peer-reviewed Genetics Medicine

Key finding: The reliability and stability of the MR analysis results were assessed by the MR-Egger intercept test, MR-PRESSO test, and heterogeneity test. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Associations between trajectories of plasma biomarkers for Alzheimer's disease, brain structures, and cognitive function: a prospective cohort study in the UK Biobank

79/100 ✓ Peer-reviewed Biomarkers Molecular psychiatry

Key finding: Higher baseline plasma GFAP and NfL were significantly associated with brain atrophy and impaired white matter microstructure. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source