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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 701–725 of 27,380 studies, newest first · page 29 of 1096.

August 2026 25

  1. 2026-08-22

    Genetic architecture of Alzheimer's disease is enriched in peripheral immune and metabolic programs

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

    Key finding: These findings extend current models of AD genetics beyond brain-resident mechanisms.

    Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  2. 2026-08-21

    Mesoscale medial temporal lobe connectivity patterns relate to tau pathology and memory in older adults

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

    Key finding: Older age was associated with lower perirhinal– hippocampal connectivity and lower network segregation, whereas higher plasma-based AD pathology was associated with higher perirhinal–hippocampal connectivity. +2 more findings

    Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  3. 2026-08-21

    Long-read genome sequencing and multi-omics in aging and neurodegeneration

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

    Key finding: We discovered >60,000 SV-QTLs across molecular traits and showed that SVs were more likely than SNVs to be fine-mapped as causal.

    Scored 28 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  4. 2026-08-21

    Genome-wide analyses reveal shared and distinct genetic architecture linking amyotrophic lateral sclerosis, sporadic frontotemporal dementia and cognitive traits

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

    Key finding: Among these genes, we observed the strongest convergent evidence for MEF2C, which was supported by multiple gene prioritisation tools (PoPS, nearest gene and SMR) and showed three-way colocalised signals between ALS, cognitive traits and an MEF2C eQTL in cerebellum. +1 more finding

    Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  5. 2026-08-21

    A Precision Aging Approach to Cognitive Aging: Clustering Multiple Domains of Risk

    ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

    Key finding: Using cluster analyses, we considered 38 risk factors associated with five categories of risk known to negatively impact cognitive aging - cardiovascular insufficiency, glucose dysregulation, inflammation, immune dysfunction, and neuropathology. +2 more findings

    Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  6. 2026-08-21

    Asymptomatic carotid artery stenosis, cognitive decline and dementia: a prospective population-based cohort study

    ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv (preprint)

    Key finding: BackgroundAsymptomatic carotid artery stenosis (ACAS) increases the risk of stroke, and is associated with cognitive decline. +4 more findings

    Scored 57 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  7. 2026-08-21

    Predicting Subjective Cognitive Decline on Future BRFSS Survey Years: An Open Multi-Language Machine Learning Benchmark

    ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv (preprint)

    Key finding: Respondents who reported no difficulty deciding (DECIDE = 2) had substantially lower odds of SCD than those who reported difficulty (DECIDE = 1; aOR approximately 0.13; FDR < 0.05).

    Scored 30 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  8. 2026-08-21

    Medicare Advantage Beneficiary Enrollment Decisions Following New Complex Conditions

    ✓ Peer-reviewed Health systems and care delivery JAMA Health Forum

    Key finding: The analytic sample included 1 054 926 beneficiaries, including 219 942 (mean [SD] age, 75.3 [6.3] years; 54.6% female) who developed new complex conditions in 2019 and 834 984 (mean [SD] age, 73.8 [5.6] years; 56.7% female) who did not develop a new complex condition in 2019. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2026-08-20

    Stable brain architecture but flexible dynamics: distinct structure - function coupling signatures link aging and genetic Alzheimer's risk to cognitive decline in 34,067 adults

    ⚠ Preprint — not yet peer-reviewed Long-term cohort studies Research Square

    Key finding: We found that SFC and DSFC followed spatially divergent aging trajectories: SFC declined primarily in sensorimotor systems, whereas DSFC decreased most prominently in higher-order networks. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  10. 2026-08-20

    Biomarker fidelity score: A quantitative framework for individual-level validation of explainability methods in 3D Alzheimer’s disease MRI classification

    ⚠ Preprint — not yet peer-reviewed Long-term cohort studies bioRxiv

    Key finding: We introduce the Biomarker Fidelity Score (BFS), a quantitative clinical AI validation tool that measures the spatial overlap between individual-level three-dimensional explainability attention maps and atlas-registered AD-relevant neuroimaging biomarker regions of interest across thirteen anatomically defined structures including the hippocampus, entorhinal cortex, amygdala, and parahippocampal gyrus. +4 more findings

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  11. 2026-08-20

    Retrospective Forecasting and Long-Term Projection of Alzheimer’s Disease Spreading

    ⚠ Preprint — not yet peer-reviewed How common it is Research Square

    Key finding: This article presents the results of a retrospective forecast of non-stationary dynamics for key indicators of the spreading process, based on constructing linear trends of the stochastic rates of change in the integral volumes of inflow and outflow.

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  12. 2026-08-20

    Medication adherence in patients with cognitive disorders

    ⚠ Preprint — not yet peer-reviewed Getting a diagnosis Research Square

    Key finding: Medication adherence in older adults was strongly influenced by cognitive impairment, gender, health literacy and cohabitation. +3 more findings

    Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  13. 2026-08-20

    Chronic Migraine and Alzheimer’s Dementia: A Candidate Mechanistic Route, and the Evidence That Would Test It

    ⚠ Preprint — not yet peer-reviewed Biomarkers Preprints.org

    Key finding: The association declines monotonically as control over ascertainment improves. +4 more findings

    Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  14. 2026-08-20

    Exploring Machine Learning Models to Uncover Pathways in ALS Pathogenesis Using Immunohistochemical Features

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

    Key finding: These findings demonstrate that estimates of machine-learning performance in quantitative neuropathology are sensitive to validation design and highlight the importance of patient-level separation when multiple pathological observations originate from the same individuals.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  15. 2026-08-20

    Performance of upper-arm capillary blood collection for Alzheimers disease and central nervous system biomarkers: comparison of Tasso+ and venous plasma

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

    Key finding: Biomarkers of Alzheimers disease (AD) and related disorders (ADRD) collected from devices like the Tasso+, a minimally invasive upper-arm capillary blood collection device, must be compared to traditional venipuncture to assess for validity. +1 more finding

    Scored 28 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  16. 2026-08-20

    Self-applied single-channel mastoid ExG for fully automated detection of REM sleep behaviour disorder

    ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv (preprint)

    Key finding: A fine-tuned deep-learning 1-channel model staged sleep at a Cohens kappa of 0.65 in PD, iRBD and controls ({kappa} = 0.73 for the 2-channel model). +4 more findings

    Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  17. 2026-08-20

    Brain organoids in Alzheimer disease and related tauopathies: Challenges and opportunities for translational readiness

    ✓ Peer-reviewed Disease mechanisms Stem Cell Reports

    Key finding: Although the recent US Food and Drug Administration (FDA) Modernization Act 2.0 has enabled non-animal preclinical pathways, brain organoid models of tauopathies remain nascent compared with other disease areas.

    Full summary, score breakdown and related studies → Original source

  18. 2026-08-19

    Disease-specific tangle immunophenotypes distinguish hippocampal vulnerability in Alzheimer’s disease and Parkinson’s disease dementia

    ⚠ Preprint — not yet peer-reviewed Lewy body dementia bioRxiv

    Key finding: Structured Abstract INTRODUCTION Tau pathology typically occurs in Alzheimeŕs disease (AD), however is also frequently present in Parkinsońs disease dementia (PDD) and Dementia with Lewy Bodies (DLB), yet its disease-specific signature is unclear. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  19. 2026-08-19

    High-Content Screening Identifies Dithiocarbamates As A Class Of Chemicals That Disrupts TDP-43 Proteostasis

    ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

    Key finding: Despite epidemiological evidence linking environmental exposures to neurodegeneration, few toxicants have been directly associated with neurodegeneration. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  20. 2026-08-19

    Multimodal Transformer-Based Fusion of Blood-Based and Digital Biomarkers for Explainable (XAI) Ultra-Early Alzheimer's Disease Detection

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

    Key finding: As a result, there is an urgent need to develop extremely early diagnosis modalities that are both accurate and feasible. +4 more findings

    Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  21. 2026-08-19

    Estimating amyloid-β deposition using brain perfusion SPECT in Alzheimer's disease

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

    Key finding: Brain perfusion SPECT revealed AD-typical hypoperfusion patterns and demonstrated modest potential to estimate the presence or absence of Aβ deposition with left parietal rCBF. +4 more findings

    Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  22. 2026-08-19

    APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics

    ✓ Peer-reviewed Genetics Nature communications

    Key finding: APOE is the strongest genetic modulator of late-onset Alzheimer's disease and exists in common variants that confer decreased, neutral, or increased risk. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2026-08-19

    GCH1 genetic variation as a prognostic factor in Parkinsons disease across populations

    ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

    Key finding: BackgroundPathogenic variants in GCH1 have been associated with Parkinsons disease (PD), but the clinical phenotype and longitudinal disease course of GCH1-associated PD remain incompletely characterized. +4 more findings

    Scored 43 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  24. 2026-08-19

    Amyloid-PET pipeline choice influences classification of preclinical Alzheimers disease

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

    Key finding: CONCLUSIONSDisagreement between A{beta}-PET methods was highest between 11-35 standard Centiloids and was frequently associated with accumulating A{beta}. +2 more findings

    Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  25. 2026-08-19

    Deep multimodal clustering identifies biological subtypes of normal aging with divergent cognitive decline risk

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv (preprint)

    Key finding: The High-Burden subgroup showed significantly worse memory and executive function, elevated cardiometabolic comorbidity, and markedly higher rates of conversion to mild cognitive impairment or dementia within two years. +1 more finding

    Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →