Newest studies

Unlocking the Sugar Code: Implications and Consequences of Glycosylation in Alzheimer’s Disease and Other Tauopathies

38/100 ✓ Peer-reviewed Disease mechanisms Biomedicines

Key finding: Both N-linked glycosylation (N-glycosylation) and O-linked glycosylation (O-glycosylation) influence tau stability, Aβ processing, receptor signaling, synaptic integrity, and neuroinflammation. +4 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Structural details of helix-mediated multimerization of the conserved region of TDP-43 C-terminal domain

52/100 ✓ Peer-reviewed Brain tissue and pathology Nature Communications

Key finding: An integrative approach combining analytical ultracentrifugation, NMR-derived contacts, AlphaFold2-Multimer modeling, and all-atom molecular dynamics simulations together suggest that TDP-43 CR forms dynamic, multimeric helical assemblies stabilized by a methionine-rich core with specific contributions from a tryptophan/leucine pair.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Clinical and neuropsychological features associated with progression in subjective cognitive decline

43/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Aging Neuroscience

Key finding: At baseline, SCDp were older, had a higher prevalence of hypertension and hypercholesterolemia and had worst performance on tests related to processing speed, verbal fluency, visual memory, verbal memory, and executive functioning. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Quantum AI for psychiatric diagnosis: enhancing dementia classification with quantum machine learning

39/100 ✓ Peer-reviewed Digital health tools Frontiers in Psychiatry

Key finding: Comprehensive experiments are conducted on benchmark ADNI-1, ADNI-2, and OASIS-2 MRI datasets, and results are reported both with and without KD.

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Correlation and Interchangeability of Amyloid, Tau, and Glucose Metabolism PET in Mild Cognitive Impairment and Alzheimer: A Review

37/100 ✓ Peer-reviewed Biomarkers Brain Sciences

Key finding: Initial results are promising (median ROC AUC scores of 0.88 (0.81–0.96)) but need to be validated.

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Association of Daily Driving Behaviors With Mild Cognitive Impairment in Older Adults Followed Over 10 Years

58/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: Among 298 participants (MCI, n = 56; NC, n = 242; mean age 75.1 years; 45.6% female), the groups were similar in age, sex, race, and APOE ε4 status at baseline, as well as in most driving behaviors. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Senescence in Aging and Alzheimer's Disease

43/100 ✓ Peer-reviewed Disease mechanisms Aging and disease

Key finding: Targeting senescence has emerged as a promising therapeutic avenue in AD. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

White matter hyperintensity burden predicts domain-specific cognitive decline across the Alzheimer’s disease continuum

51/100 ✓ Peer-reviewed Vascular contributions Scientific Reports

Key finding: Within the MCI group, significant negative associations emerged between WMH volume and memory (β=-0.13, adjusted p = 0.045) and language scores (β=-0.12, adjusted p = 0.045). +1 more finding

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Activated microglial exosomes enhance α-Synuclein internalization and accelerate neurodegeneration in lewy body dementia

38/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Nanobiotechnology

Key finding: We found that exosomes derived from activated microglia exacerbate α-Syn deposition and cognitive deficits, whereas microglial depletion mitigates these pathological changes. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Acupuncture reduces neuroinflammation and apoptosis, regulates peripheral immunity, and modulates T-cell subset distribution in vascular dementia rats

32/100 ✓ Peer-reviewed Inflammation and the immune system Chinese Medicine

Key finding: Acupuncture ameliorated cognitive impairment in VD rats, reduced hippocampal neuronal damage and apoptosis, downregulated pro-apoptotic proteins (cleaved-caspase 3 and Bax), and upregulated anti-apoptotic Bcl-2. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Clinical and Biological Significance of Neuroinflammation Indicators to Predict the Course of Amnestic Mild Cognitive Impairment

30/100 ✓ Peer-reviewed Mild cognitive impairment Psikhiatriya

Key finding: the cytokines set and immune response indicators have been identified. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Evidence for divergent cortical organisation in Parkinson’s disease and Lewy Body Dementia

49/100 ✓ Peer-reviewed Lewy body dementia Nature Communications

Key finding: We show divergent structural gradient differences with cognitive impairment: PD-NC show increased inter-regional differentiation, whilst LBD show overall gradient distribution similar to controls despite widespread organisational differences at the regional level.

• Other Dementias

Full summary, score breakdown and related studies → Original source

The Role of Amyloid- and Tau PET in the New Era of Alzheimer Disease Therapies

46/100 ✓ Peer-reviewed Brain scans and imaging Journal of Nuclear Medicine

Key finding: These imaging modalities have played a central role in the clinical trials that led to the recent approval of Aβ-targeting therapies, with Aβ PET used for participant selection and treatment monitoring and tau PET increasingly integrated to assess disease staging and prognosis. +4 more findings

• Brain Scans
• Treatments

Full summary, score breakdown and related studies → Original source

Multi-model deep learning for dementia detection: addressing data and model limitations

35/100 ✓ Peer-reviewed Getting a diagnosis Frontiers in Neuroscience

Key finding: Among all evaluated models, the 3D-CNN and multimodal attention models achieved the highest performance, with accuracies of 84% and 86%, specificities of 83% and 86%, and sensitivities of 84% and 86%, respectively. +4 more findings

Full summary, score breakdown and related studies → Original source

Neuropharmacology of Alzheimer Disease

39/100 ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

Key finding: Neuropharmacological treatments aim to influence these processes to relieve symptoms and slow disease progression. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Neuropharmacology of Alzheimer Disease

28/100 ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

Key finding: Neuropharmacological treatments aim to influence these processes to relieve symptoms and slow disease progression. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

The Gut-Brain Axis in Alzheimer's Disease: Exploring Microbial Influences and Therapeutic Strategies

43/100 ✓ Peer-reviewed Disease mechanisms Molecular neurobiology

Key finding: Disruption of the gut microbial balance-known as dysbiosis-has been associated with increased amyloid-beta (Aβ) deposition, tau hyperphosphorylation, oxidative stress, neuroinflammation, and impaired neurotransmission, all of which are key pathological features of AD. +1 more finding

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Nanobodies targeting hnRNPA2/B1 and tau

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv : the preprint server for biology

Key finding: Furthermore, fusion to ubiquitin ligase adaptor domains significantly decreased hnRNPA2/B1 and tau levels.

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Higher phosphorylated tau levels predict cognitive decline and amyloid-related imaging abnormalities during lecanemab treatment: clinical practice data

72/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy

Key finding: Lecanemab was generally well tolerated by most patients with early AD and treatment appeared to be more effective and safer in patients with low CSF-ptau181 levels. +4 more findings

• Treatments
• Brain Scans
• Side Effects

Full summary, score breakdown and related studies → Original source

Inhibition of p38α MAPK increases short-term astrocyte reactivity: the exploratory VIP trial in early Alzheimer's disease

59/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

Key finding: Neuro-inflammation was not reduced between the neflamapimod and placebo groups, and no change was observed in [18F]-DPA-714 PET. +4 more findings

• Clinical Trials
• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Prevalence of cognitive morbidity including delirium in 51,202 emergency hospital admissions across 29 medical and surgical specialties in ORCHARD-EPR: a cross-sectional study

45/100 ✓ Peer-reviewed Clinical safety EClinicalMedicine

Key finding: Among 51,202 admissions (mean/SD age = 82/7 years), any cognitive morbidity was present in 18,225 (35.6%, 95% CI 35.2-36.0%): delirium occurred in 24.0% (n = 12,289, of which 14.3% (n = 7332) had delirium only and 9.7% (n = 4957) had delirium + dementia) dementia only in 8.7%, (n = 4450), AMTS <8 in 2.9% (n = 1486). +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Global burden, spatiotemporal disparities, and sex-specific trends of early- and late-onset Alzheimer’s disease and other dementias: a comparative analysis and projections to 2035

38/100 ✓ Peer-reviewed Disparities BMC Neurology

Key finding: In 2021, LOAD demonstrated a substantially higher global burden than EOAD: incidence cases (8,455,150 [95% UI: 5,818,063-11,461,560] vs. 1,381,906 [894,768-1,963,453]), mortality cases (1,879,291 [471,472-4,968,222] vs. 73,386 [14,059-232,170]), and DALYs (32,558,570 [14,907,368-71,154,572] vs. 3,774,117 [1,696,439-8,881,154]). +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Caregiver Burden in Prion Disease

32/100 ✓ Peer-reviewed Caregiving Dementia and Geriatric Cognitive Disorders Extra

Key finding: Thirty caregiver-patient dyads were followed longitudinally. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Association Between Choroid Plexus Morphological Alterations, Alzheimer Pathologies, and Cognitive Impairment

41/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Our approach captured the complex morphological alterations of the ChP in AD. +2 more findings

Full summary, score breakdown and related studies → Original source

Digital Dementia: Smart Technologies, mHealth Applications and IoT Devices, for Dementia-Friendly Environments

34/100 ✓ Peer-reviewed Getting a diagnosis Journal of Sensor and Actuator Networks

Key finding: In parallel, the study identifies promising pathways for energy-optimised IoT systems, Artificial Intelligence (AI), and Ambient Assisted Living (AAL) technologies in fostering dementia-friendly, sustainable environments. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source