Newest studies

Biomarker profile of a Chinese ALS cohort: A comprehensive clinical-biomarkers-imaging analysis

43/100 ✓ Peer-reviewed Biomarkers Neurobiology of disease

Key finding: Firstly, we found that plasma levels of NfL (p < 0.001) and p-tau181 (p < 0.001) were significantly higher in ALS than in HC. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv : the preprint server for health sciences

Key finding: At baseline, higher AgeAccelPheno was associated with lower amyloid-β42 to amyloid-β40 (Aβ42:Aβ40) ratio, and higher AgeAccelGrim2 was associated with elevated neurofilament light (NfL). +2 more findings

• Biomarkers

Scored 25 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Surrogate Decision‐Making Practices Regarding End‐of‐Life Care for People With Dementia in Long‐Term Care Hospitals: A Qualitative Descriptive Study

38/100 ✓ Peer-reviewed End-of-life care Journal of Advanced Nursing

Key finding: The analysis yielded three categories and nine subcategories describing surrogate decision-making practices regarding end-of-life care for people with dementia: (a) typical circumstances of end-of-life care planning, (b) expected roles of key personnel and related challenges and (c) important considerations. +4 more findings

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

The role of the Mediterranean diet in the treatment of cognitive dysfunction in patients with type 2 diabetes mellitus

61/100 ✓ Peer-reviewed Prevention trials Frontiers in Nutrition

Key finding: The global metabolic disorder, type 2 diabetes mellitus (T2DM), significantly increases the risk of cognitive dysfunction, including Alzheimer's disease (AD) and mild cognitive impairment (MCI). +4 more findings

• Lifestyle
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Precision Nutrition for Dementia: Exploring the Potential in Mitigating Dementia Progression

29/100 ✓ Peer-reviewed Inflammation and the immune system Journal of dementia and Alzheimer's disease

Key finding: This narrative review addresses this gap by synthesising evidence on nutrient–gene interactions, genotype, gut microbiome, nutritional status and the interplay between metabolic pathways implicated in neuroinflammation and neurodegeneration to modify disease progression in a protective or therapeutic manner. +4 more findings

• Lifestyle
• Genetics

Full summary, score breakdown and related studies → Original source

Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia

57/100 ✓ Peer-reviewed Brain tissue and pathology Communications Medicine

Key finding: We investigated whether a discrepancy between chronological and biological age in midlife and late-life is associated with cognition and dementia risk. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Dementia Caregivers’ Perspectives on Technology’s Place in Care Practices: Mixed Methods Survey

38/100 ✓ Peer-reviewed Caregiving JMIR Formative Research

Key finding: Respondents (N=69) identified access to resources as the most important unmet need for caregivers (53%). +4 more findings

• Caregiving
• Digital Tools

Full summary, score breakdown and related studies → Original source

Caregivers’ burden analytics: combining variables from patients with dementia and their caregivers

48/100 ✓ Peer-reviewed Caregiving BMC Geriatrics

Key finding: One hundred and fifty rules were found for caregivers with a moderate to severe burden, and these rules can be further summarized into twenty general rules. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

The effect of tablet-based multimodal training on cognitive functioning in Alzheimer's disease: A randomized controlled trial

77/100 ✓ Peer-reviewed Cognitive tests and assessment PloS one

Key finding: Over six months, the intervention group showed a stable global cognitive function score (Mini Mental Status Examination), whereas the control group showed a cognitive decline (ANCOVA-interaction: F1, 14 = 5.083, p = .041; controlled for disease duration and education). +4 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Delivery of Palliative Care in the Last Year of Life to Individuals Receiving Maintenance Dialysis: A Population-Level Cross-Sectional Study

55/100 ✓ Peer-reviewed End-of-life care American Journal of Kidney Diseases

Key finding: ANALYTICAL APPROACH: Descriptive statistics characterizing physician-delivered palliative care. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Role of prion protein in mediating the synaptotoxic effects of tau oligomers: Implications for Alzheimer’s disease and related tauopathies

32/100 ✓ Peer-reviewed Disease mechanisms Neural Regeneration Research

Key finding: We recently confirmed and extended these findings using recombinant TauOs generated from full-length human tau in the presence of arachidonic acid (Balducci et al., 2025; Figure 1). +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Novel approaches for the treatment of frontotemporal dementia: is there hope for the future?

38/100 ✓ Peer-reviewed Lewy body dementia Expert Review of Neurotherapeutics

Key finding: Frontotemporal dementia (FTD) refers to a group of neurodegenerative disorders characterized clinically by behavioral disturbances and pathologically by frontal and anterior temporal lobe neurodegeneration, resulting in brain atrophy. +4 more findings

• Treatments
• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Gender differences in spousal caregiver strain and paid service use among dementia caregivers in rural Appalachia

39/100 ✓ Peer-reviewed Caregiving Frontiers in Public Health

Key finding: Although husbands reported significantly lower loneliness and overload than wives, the overall use of paid services was similar across husbands and wives. +2 more findings

• Caregiving
• Health Equity

Full summary, score breakdown and related studies → Original source

The Relationship Between Brainstem Structural Anatomical Parameters And Cognitive Function Impairment Based On The Indonesian Version Of Montreal Cognitive Assessment Score In Clinical Dementia Patients

34/100 ✓ Peer-reviewed Getting a diagnosis Eduvest - Journal Of Universal Studies

Key finding: Dementia is a neurodegenerative disorder characterized by a significant decline in cognitive function. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension

58/100 ✓ Peer-reviewed Prevention and risk Hypertension Research

Key finding: High genetic risk and poor lifestyle were associated with increased hypertension risk. +2 more findings

• Lifestyle
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

American Indian Caregivers Policy

36/100 ✓ Peer-reviewed Risk factors Fourth World Journal

Key finding: The American Indian and Alaska Native elder population that is disabled as a result of dementia rely on the care and help of an estimated 3,1601 individuals in tribal communities (the vast majority of whom are women) on and near Indian reservations and in cities in Washington.

• Caregiving
• Policy

Full summary, score breakdown and related studies → Original source

Enhancing Alzheimer Disease Detection Using Neuropsychiatric Symptoms: The Role of Mild Behavioural Impairment in the Revised NIA-AA Research Framework

47/100 ✓ Peer-reviewed Tau biomarkers Journal of geriatric psychiatry and neurology

Key finding: Mild behavioral impairment (MBI), which captures emergent and persistent neuropsychiatric symptoms (NPS) in later life, may enhance early detection of AD; however, its associations with 2024 NIA-AA Core 1 biomarkers remain unexplored. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Cerebrovascular p16INK4A expression induces cerebral small vessel disease-related phenotypes

43/100 ✓ Peer-reviewed Vascular contributions Acta neuropathologica communications

Key finding: Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive impairment and dementia (VCID) and highly associated with Alzheimer's disease pathogenesis. +2 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma neurofilament light reflects more severe manifestation of Alzheimer's disease in men

59/100 ✓ Peer-reviewed Biomarkers Molecular psychiatry

Key finding: A Cox model with bootstrap resampling was used to evaluate sex differences in dementia risk, calculating the hazard ratio for men versus women for a given increase in plasma NfL. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Substitutions of Sleep, Physical Activity, and Sedentary Behaviour and the Risk of Dementia and Stroke

42/100 ✓ Peer-reviewed Vascular contributions Journal of Sleep Research

Key finding: We assessed how substitutions of sleep, sedentary behaviour, and PA are associated with incident dementia and stroke, using compositional analysis. +3 more findings

• Risk Factors
• Lifestyle
• Prevention

Full summary, score breakdown and related studies → Original source

Exercise therapy for the treatment of delirium in the intensive care unit

58/100 ✓ Peer-reviewed Clinical safety Cochrane Database of Systematic Reviews

Key finding: Outcomes of interest were duration of delirium, health-related quality of life, delirium severity, cognitive function, mortality in the ICU, ICU length of stay, hospital length of stay and adverse events. +4 more findings

• Treatments
• Lifestyle

Full summary, score breakdown and related studies → Original source

Improving quality of life for institutionalized individuals with advanced dementia: A pilot study on efficacy of a semi-immersive virtual reality driving simulator for individuals with advanced dementia

30/100 ✓ Peer-reviewed Prevention trials Displays

Key finding: Their driving performance indicators demonstrated implicit memory improvement evidenced by a decrease in total crashes and an increase in the game score.

• Digital Tools

Full summary, score breakdown and related studies → Original source

Reliable New Biomarkers of Mitochondrial Oxidative Stress and Neuroinflammation in Cerebrospinal Fluid and Plasma from Alzheimer’s Disease Patients: A Pilot Study

43/100 ✓ Peer-reviewed Inflammation and the immune system International Journal of Molecular Sciences

Key finding: As for SOD2, an MCI male-specific significant increase in both biofluids and an ADd male-specific significant decrease in plasma were found. +4 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Clinical parameters predicted the progression to dementia in oldest old patients with mild cognitive impairment (MCI)

42/100 ✓ Peer-reviewed Mild cognitive impairment International Psychogeriatrics

Key finding: Fifty-nine patients fulfilled the inclusion criteria. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein

38/100 ✓ Peer-reviewed Lewy body dementia Molecular Neurodegeneration

Key finding: As the second most prevalent form of neurodegenerative dementia after Alzheimer’s disease (AD), LBD necessitates a deeper understanding of its pathogenesis to enable the development of targeted therapeutic interventions. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source