Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,051–19,075 of 27,380 studies, newest first · page 763 of 1096.
December 2012 13
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2012-12-01
Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts
47/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: However, the natural history of these lesions remains largely unexplored. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-01
The neuropathology and neurobiology of traumatic brain injury
53/100 ✓ Peer-reviewed Brain tissue and pathology Neuron
Key finding: In this Review, we discuss the neuropathology and neural mechanisms associated with TBI, drawing on findings from sports-induced TBI in athletes, in whom acute TBI damages axons and elicits both regenerative and degenerative tissue responses in the brain and in whom repeated concussions may initiate a long-term neurodegenerative process called dementia pugilistica or chronic traumatic encephalopathy (CTE). +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-01
Confirmatory factor analysis of the ADNI Neuropsychological Battery
51/100 ✓ Peer-reviewed Long-term cohort studies Brain imaging and behavior
Key finding: Detailed neuropsychological testing was conducted on all participants. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-01
A composite score for executive functioning, validated in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment
56/100 ✓ Peer-reviewed Long-term cohort studies Brain imaging and behavior
Key finding: This study investigates whether a composite executive function measure based on these multiple indicators has better psychometric characteristics than the widely used individual components. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-01
The Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-Plus): an expansion of the ADAS-Cog to improve responsiveness in MCI
51/100 ✓ Peer-reviewed Cognitive tests and assessment Brain imaging and behavior
Key finding: The Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-Cog) is widely used in AD, but may be less responsive to change when used in people with mild cognitive impairment (MCI). +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-01
Mild cognitive impairment in moderate to severe COPD: a preliminary study
54/100 ✓ Peer-reviewed Cognitive tests and assessment Chest
Key finding: Cognitive impairment is a frequent feature of COPD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-01
Development and assessment of a composite score for memory in the Alzheimer's Disease Neuroimaging Initiative (ADNI)
60/100 ✓ Peer-reviewed Cognitive tests and assessment Brain imaging and behavior
Key finding: We used modern psychometric approaches to analyze longitudinal Rey Auditory Verbal Learning Test (RAVLT, 2 versions), AD Assessment Schedule - Cognition (ADAS-Cog, 3 versions), Mini-Mental State Examination (MMSE), and Logical Memory data to develop ADNI-Mem, a composite memory score. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-01
Alzheimer's Disease in Down Syndrome
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's European journal of neurodegenerative disease
Key finding: A key challenge to adults with Down syndrome (DS) as they age is an increased risk for cognitive decline, dementia, and Alzheimer disease (AD). +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-12-01
Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community
65/100 ✓ Peer-reviewed Caregiving Archives of neurology
Key finding: The findings highlight the regional specificity of the association of WMHs with AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-12-01
Practical lessons from amyloid immunotherapy trials in Alzheimer disease
50/100 ✓ Peer-reviewed Treatments Current Alzheimer research
Key finding: More open debates of practical experiences from different trial centres and sponsors are essential for optimizing trial designs and improving conditions for participants. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-12-01
Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease
58/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Phenotypic personality dimensions, primarily neuroticism and extraversion, moderate the relationship between APOE [Latin Small Letter Open E]-4 genotype and cognitive outcomes among older adults.
Full summary, score breakdown and related studies → Original source
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2012-12-01
Cognitive outcomes after sertaline treatment in patients with depression of Alzheimer disease
64/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Treatment with sertraline in patients with dAD is not associated with greater improvement in cognition at week 24 than treatment with placebo. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-12-01
Investigation of c9orf72 in 4 neurodegenerative disorders
52/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: The C9orf72 expansion is a common cause of ALS and FTLD, but not of AD or PD. +3 more findings
Full summary, score breakdown and related studies → Original source
November 2012 12
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2012-11-30
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias
51/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology
Key finding: This study investigated the frequency and severity of atherosclerotic plaques in the circle of Willis in Alzheimer's disease and multiple other neurodegenerative diseases. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-11-30
Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains
53/100 ✓ Peer-reviewed Brain tissue and pathology PloS one
Key finding: Large-scale genome wide association studies (GWAS) for LOAD have identified 10 novel risk genes: ABCA7, BIN1, CD2AP, CD33, CLU, CR1, EPHA1, MS4A6A, MS4A6E, and PICALM. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-11-29
Nerve growth factor: from the early discoveries to the potential clinical use
40/100 ✓ Peer-reviewed Brain scans and imaging Journal of translational medicine
Key finding: NGF plays its trophic role both during development and in adulthood, ensuring the maintenance of phenotypic and functional characteristic of several populations of neurons as well as immune cells. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-11-28
Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease
40/100 ✓ Peer-reviewed Vascular contributions Brain pathology (Zurich, Switzerland)
Key finding: Moreover, loss of pericytes was associated with BBB breakdown in patients with amyotrophic lateral sclerosis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-11-28
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis
40/100 ✓ Peer-reviewed Genetics Human molecular genetics
Key finding: Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-11-28
Does case conferencing for people with advanced dementia living in nursing homes improve care outcomes: evidence from an integrative review?
43/100 ✓ Peer-reviewed End-of-life care International journal of nursing studies
Key finding: Case conferencing provides opportunities to improve care palliative care outcomes for older people with dementia by engaging family and all relevant internal and external health providers in prospective care planning. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-11-27
100 years of Lewy pathology
36/100 ✓ Peer-reviewed Brain tissue and pathology Nature reviews. Neurology
Key finding: In 1912, Fritz Heinrich Lewy identified the protein aggregates that define Parkinson disease (PD) in some brain regions outside the substantia nigra. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-11-27
Deciphering the mechanism underlying late-onset Alzheimer disease
45/100 ✓ Peer-reviewed Risk genes beyond APOE Nature reviews. Neurology
Key finding: A potential problem underlying these failures is the assumption that the molecular mechanism mediating the genetically determined form of the disease is identical to the one resulting in late-onset AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-11-27
Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
52/100 ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry
Key finding: The accumulation of Tau into aggregates is associated with key pathological events in frontotemporal lobe degeneration (FTD-Tau) and Alzheimer disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-11-24
Patterns of comorbidity and multimorbidity in the oldest old: the Octabaix study
40/100 ✓ Peer-reviewed Risk factors European journal of internal medicine
Key finding: The large majority of oldest old subjects had multimorbidity. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-11-22
Prognostic indicators of 6-month mortality in elderly people with advanced dementia: a systematic review
60/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: Although the majority of studies agreed that the Functional Assessment Staging 7c criterion was not a reliable predictor of 6-month mortality, we found a lack of prognosticator concordance across the literature. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-11-22
Long-term anticholinergic use and the aging brain
61/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Exposure to medications with severe AC cognitive burden may be a risk factor for developing MCI. +1 more finding
Full summary, score breakdown and related studies → Original source
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