Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,301–20,325 of 27,380 studies, newest first · page 813 of 1096.
February 2011 6
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2011-02-01
The diagnostic challenge of psychiatric symptoms in neurodegenerative disease: rates of and risk factors for prior psychiatric diagnosis in patients with early neurodegenerative disease
56/100 ✓ Peer-reviewed Getting a diagnosis The Journal of clinical psychiatry
Key finding: Depression was the most common psychiatric diagnosis in all groups. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-02-01
Hearing loss and incident dementia
71/100 ✓ Peer-reviewed Prevention and risk Archives of neurology
Key finding: Hearing loss is independently associated with incident all-cause dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-02-01
A new proposal for randomized start design to investigate disease-modifying therapies for Alzheimer disease
50/100 ✓ Peer-reviewed Treatments Clinical trials (London, England)
Key finding: The greatest advantage of the RSD proposed in this article is its ability to critically address the question on a DM effect.
Full summary, score breakdown and related studies → Original source
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2011-02-01
Preservation of the capacity to appoint a proxy decision maker: implications for dementia research
49/100 ✓ Peer-reviewed Treatments Archives of general psychiatry
Key finding: A substantial proportion of persons with AD who were thought incapable of consenting to lower-risk or higher-risk studies have preserved capacity for appointing a research proxy. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-02-01
Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)
74/100 ✓ Peer-reviewed Treatments Archives of medical science : AMS
Key finding: The primary planned analyses did not show a significant treatment effect, but were confounded by unexplained variance. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-02-01
The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels
57/100 ✓ Peer-reviewed Genetics Archives of general psychiatry
Key finding: Furthermore, the CSF biomarker analyses provide a first insight into the potentially predominant pathogenetic mechanism(s) underlying the association between AD risk and PICALM.
Full summary, score breakdown and related studies → Original source
January 2011 19
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2011-01-31
Exercise training increases size of hippocampus and improves memory
77/100 ✓ Peer-reviewed Prevention and risk Proceedings of the National Academy of Sciences of the United States of America
Key finding: The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk for dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-29
The Montreal Cognitive Assessment and the mini-mental state examination as screening instruments for cognitive impairment: item analyses and threshold scores
56/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia and geriatric cognitive disorders
Key finding: 135 subjects enrolled in a longitudinal clinicopathologic study were administered the MoCA by a single physician and the MMSE by a trained research assistant. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-28
Predictors of non-invasive ventilation tolerance in amyotrophic lateral sclerosis
43/100 ✓ Peer-reviewed End-of-life care Journal of the neurological sciences
Key finding: Our study shows that an intensive educational training and adaptation on non-invasive ventilation, when performed in a hospital multidisciplinary setting, increases compliance and tolerance over time, even in those patients with severe bulbar impairment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-27
Characterizing Alzheimer's disease using a hypometabolic convergence index
51/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage
Key finding: HCIs were significantly different in the probable AD, MCI converter, MCI stable and NC groups (p=9e-17) and correlated with clinical disease severity. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-26
The effect of cognitive impairment on the accuracy of the presenting complaint and discharge instruction comprehension in older emergency department patients
52/100 ✓ Peer-reviewed Risk factors Annals of emergency medicine
Key finding: Proportional odds logistic regression was performed to determine whether cognitive impairment was associated with presenting complaint accuracy and discharge instruction comprehension. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-26
Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes
36/100 ✓ Peer-reviewed Drug development Neuropharmacology
Key finding: Currently there is widening recognition that AD is closely associated with impaired insulin signaling and glucose metabolism in brain, suggesting it to be a brain-specific form of diabetes and so also termed as "type 3 diabetes". +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-26
Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Brain research reviews
Key finding: Numerous studies analyzing human postmortem tissue, animal models and cellular paradigms indicate that AD pathology has a deleterious effect on the pathways governing actin cytoskeleton stability.
Full summary, score breakdown and related studies → Original source
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2011-01-26
The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies
69/100 ✓ Peer-reviewed Risk factors BMC medical genomics
Key finding: The eMERGE (electronic MEdical Records and GEnomics) Network is an NHGRI-supported consortium of five institutions to explore the utility of DNA repositories coupled to Electronic Medical Record (EMR) systems for advancing discovery in genome science. eMERGE also includes a special emphasis on the ethical, legal and social issues related to these endeavors. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-25
CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease
46/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation
Key finding: Parkinson's disease is characterized by a progressive loss of dopaminergic neurons in the substantia nigra. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-25
Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism
44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Alterations in protein homeostasis and mTOR activity and signaling have been reported in several neurodegenerative disorders, including Alzheimer disease (AD); however, the causes of such deregulations remain elusive. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-25
Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment
60/100 ✓ Peer-reviewed Digital health tools NeuroImage
Key finding: Individuals with mild cognitive impairment (MCI) are at increased risk of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-21
Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease
40/100 ✓ Peer-reviewed Genetics PloS one
Key finding: Recent studies strongly indicate that aberrations in the control of gene expression might contribute to the initiation and progression of Alzheimer's disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-21
Neuropsychiatric and cognitive profile of patients with DSM-IV delirium referred to an old age psychiatry consultation-liaison service
36/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics
Key finding: Delirium is a complex neuropsychiatric syndrome with generalized cognitive impairment and disproportionate inattention. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-21
Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research
70/100 ✓ Peer-reviewed Risk factors Psychosomatic medicine
Key finding: The current study suggests that the degree of HPA hyperactivity can vary considerably across patient groups. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-21
Assessing end-of-life preferences for advanced dementia in rural patients using an educational video: a randomized controlled trial
65/100 ✓ Peer-reviewed Disparities Journal of palliative medicine
Key finding: Rural subjects with higher health literacy were more likely to want comfort care compared to those with lower levels of health literacy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-20
Family caregiving in dementia: the Asian perspective of a global problem
54/100 ✓ Peer-reviewed Caregiving Dementia and geriatric cognitive disorders
Key finding: A full understanding of the specific way that culture could influence family caregivers' burdens may play an important part in the development of a holistic model for family-centered care. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-20
REST regulates DYRK1A transcription in a negative feedback loop
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of biological chemistry
Key finding: Here, we found that REST can activate DYRK1A transcription via a neuron-restrictive silencer element at bp -833 to -815 of human DYRK1A promoter. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-19
Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer's disease: a proof of concept study
43/100 ✓ Peer-reviewed Brain scans and imaging Journal of neural transmission (Vienna, Austria : 1996)
Key finding: Primary objectives were average improvement of Alzheimer Disease Assessment Scale-Cognitive (ADAS-cog) and Clinical Global Impression of Change (CGIC) (after 6 weeks and 4.5 months, compared to baseline).
Full summary, score breakdown and related studies → Original source
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2011-01-19
Classification of Alzheimer disease, mild cognitive impairment, and normal cognitive status with large-scale network analysis based on resting-state functional MR imaging
47/100 ✓ Peer-reviewed Brain scans and imaging Radiology
Key finding: LSN analysis revealed that interconnectivity patterns of brain regions can be used to classify subjects with AD, those with aMCI, and CN subjects. +4 more findings
Full summary, score breakdown and related studies → Original source
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