alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 17,801–17,825 of 27,380 studies, newest first · page 713 of 1096.

June 2014 25

  1. 2014-06-11

    Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial

    ✓ Peer-reviewed Costs and economics Lancet (London, England)

    Key finding: EQ-5D utility scores averaged 0·03 (95% CI 0·01-0·05; p=0·0002) better with levodopa than with levodopa-sparing therapy; rates of dementia (hazard ratio [HR] 0·81, 95% CI 0·61-1·08, p=0·14), admissions to institutions (0·86, 0·63-1·18; p=0·4), and death (0·85, 0·69-1·06, p=0·17) were not significantly different, but the upper CIs precluded any substantial increase with levodopa compared with levodopa-sparing therapy. 179 (28%) of 632 patients allocated dopamine agonists and 104 (23%) of 460 patients allocated MAOBI discontinued allocated treatment because of side-effects compared with 11 (2%) of 528 patients allocated levodopa (p<0·0001). +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2014-06-11

    Hypocretin and brain β-amyloid peptide interactions in cognitive disorders and narcolepsy

    ✓ Peer-reviewed Tau biomarkers Frontiers in aging neuroscience

    Key finding: Sleep disturbances are frequent in AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2014-06-10

    The new DSM-5 diagnosis of mild neurocognitive disorder and its relation to research in mild cognitive impairment

    ✓ Peer-reviewed Prevention and risk Aging & mental health

    Key finding: In this article, we will focus on mNCD by reviewing the relevant literature on MCI. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2014-06-07

    Burdensome transitions at the end of life among long-term care residents with dementia

    ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

    Key finding: The ongoing change in long-term care from institutional care to housing services causes major challenges to the continuity of end-of-life care.

    Full summary, score breakdown and related studies → Original source

  5. 2014-06-07

    Telemedicine and the evaluation of cognitive impairment: the additive value of neuropsychological assessment

    ✓ Peer-reviewed Disparities Journal of the American Medical Directors Association

    Key finding: Teleneuropsychology is proving to be an excellent resource for clarifying cognitive and psychiatric diagnoses, and integrating individual strengths, weaknesses, and preferences into treatment and care plans used by other health care providers, patients, and caregivers. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2014-06-06

    Apolipoprotein E Allele and Hearing Thresholds in Older Adults

    ✓ Peer-reviewed Risk factors American journal of Alzheimer's disease and other dementias

    Key finding: Compared to participants with no APOE-E4 alleles, participants with 1 allele had better thresholds at 4.0 kHz (β = -2.72 dB, P = .013) and 8.0 kHz (β = -3.05 kHz, P = .006), and participants with 2 alleles had better hearing thresholds at 1.0 kHz (β = -8.56 dB, P = .021). +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2014-06-06

    Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics

    ✓ Peer-reviewed Biomarkers Molecular neurodegeneration

    Key finding: Using a targeted proteomics approach, we confirmed previous findings for a subset of markers, defined longitudinal performance of our panel of markers, and established a flexible proteomics method for robust multiplexed analyses. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2014-06-06

    Acupuncture stimulation of Taichong (Liv3) and Hegu (LI4) modulates the default mode network activity in Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging American journal of Alzheimer's disease and other dementias

    Key finding: It was found that the acupuncture stimulation could modulate the DMN activity in AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2014-06-06

    Vascular risk and Aβ interact to reduce cortical thickness in AD vulnerable brain regions

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Aβ and vascular risk interact to enhance cortical thinning in posterior brain regions that are particularly vulnerable to AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2014-06-05

    Ryanodine receptors: physiological function and deregulation in Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Molecular neurodegeneration

    Key finding: Accordingly, different studies have reported alterations of the expression and the function of Ryanodine Receptors (RyR) in human AD-affected brains, in cells expressing familial AD-linked mutations on the β amyloid precursor protein (βAPP) and presenilins (the catalytic core in γ-secretase complexes cleaving the βAPP, thereby generating amyloid β (Aβ) peptides), as well as in the brain of various transgenic AD mice models. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2014-06-05

    Oxidative stress and Down syndrome. Do antioxidants play a role in therapy?

    ✓ Peer-reviewed Down syndrome and Alzheimer's Physiological research

    Key finding: Oxidative stress is a phenomenon associated with imbalance between production of free radicals and reactive metabolites (e.g. superoxide and hydrogen peroxide) and the antioxidant defences. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2014-06-05

    The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT)

    ✓ Peer-reviewed Risk factors Clinical trials (London, England)

    Key finding: The Systolic Blood Pressure Intervention Trial will provide important information on the risks and benefits of intensive blood pressure treatment targets in a diverse sample of high-risk participants, including those with prior cardiovascular disease, chronic kidney disease, and those aged ≥75 years. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2014-06-04

    Agent Orange exposure and disease prevalence in Korean Vietnam veterans: the Korean veterans health study

    ✓ Peer-reviewed Digital health tools Environmental research

    Key finding: The adjusted ORs were significantly higher in the high exposure group than in the low exposure group for hypothyroidism (OR=1.13), autoimmune thyroiditis (OR=1.93), diabetes mellitus (OR=1.04), other endocrine gland disorders including pituitary gland disorders (OR=1.43), amyloidosis (OR=3.02), systemic atrophies affecting the nervous system including spinal muscular atrophy (OR=1.27), Alzheimer disease (OR=1.64), peripheral polyneuropathies (OR=1.09), angina pectoris (OR=1.04), stroke (OR=1.09), chronic obstructive pulmonary diseases (COPD) including chronic bronchitis (OR=1.05) and bronchiectasis (OR=1.16), asthma (OR=1.04), peptic ulcer (OR=1.03), and liver cirrhosis (OR=1.08). +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2014-06-04

    Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy

    ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry

    Key finding: Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI) criteria. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2014-06-04

    Coding variants in TREM2 increase risk for Alzheimer's disease

    ✓ Peer-reviewed Genetics Human molecular genetics

    Key finding: Two variants, p.R47H [P = 9.17 × 10(-4), odds ratio (OR) = 2.63 (1.44-4.81)] and p.R62H [P = 2.36 × 10(-4), OR = 2.36 (1.47-3.80)] were significantly associated with disease risk in single-variant analyses. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2014-06-03

    ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

    ✓ Peer-reviewed Brain tissue and pathology Nature communications

    Key finding: However, the mechanisms by which regions of the ER become tethered to mitochondria are not properly known. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2014-06-03

    Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

    Key finding: Recent genome-wide association studies linked variants in TREM2 to a strong increase in the odds of developing Alzheimer's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2014-06-03

    Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial

    ✓ Peer-reviewed Treatments Trials

    Key finding: The intervention is oral simvastatin 40 mg at night for 12 months, versus placebo.

    Full summary, score breakdown and related studies → Original source

  19. 2014-06-02

    Quality of life in dementia: a systematically conducted narrative review of dementia-specific measurement scales

    ✓ Peer-reviewed Costs and economics Aging & mental health

    Key finding: The lack of consensus on measuring QoL in dementia suggests a need for a broader, more rigorously tested QoL measure.

    Full summary, score breakdown and related studies → Original source

  20. 2014-06-02

    Duration of postoperative delirium is an independent predictor of 6-month mortality in older adults after hip fracture

    ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

    Key finding: In older adults undergoing hip fracture surgery, duration of POD is an important prognostic factor for 6-month mortality.

    Full summary, score breakdown and related studies → Original source

  21. 2014-06 month only

    LEVERAGING LOCAL IDENTITY-BY-DESCENT INCREASES THE POWER OF CASE/CONTROL GWAS WITH RELATED INDIVIDUALS

    ✓ Peer-reviewed Genetics The annals of applied statistics

    Key finding: In studies robust to population stratification, such as those with case/control sibling pairs, simulations show that the study power can be increased by over 50%. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2014-06-01

    Smoking and increased Alzheimer's disease risk: a review of potential mechanisms

    ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: A reduction in the incidence of smoking will likely reduce the future prevalence of AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2014-06-01

    The amyloid state and its association with protein misfolding diseases

    ✓ Peer-reviewed Risk factors Nature reviews. Molecular cell biology

    Key finding: The phenomenon of protein aggregation and amyloid formation has become the subject of rapidly increasing research activities across a wide range of scientific disciplines. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2014-06-01

    Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine

    ✓ Peer-reviewed Treatments Expert opinion on drug safety

    Key finding: Patients diagnosed with AD still mostly benefit from four compounds to significantly improve cognition functions and overall health and help manage other symptoms or even prolong the symptom-free period. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2014-06-01

    The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

    ✓ Peer-reviewed Hippocampus size on brain scans Brain imaging and behavior

    Key finding: By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →