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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 19,026–19,050 of 27,380 studies, newest first · page 762 of 1096.

December 2012 25

  1. 2012-12-19

    Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia

    ✓ Peer-reviewed Genetics Neurology

    Key finding: These findings suggest that APOE genotype has a differential effect on the distribution of amyloid plaques and glucose metabolism. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2012-12-19

    NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

    ✓ Peer-reviewed Inflammation and the immune system Nature

    Key finding: Deposition of amyloid-β peptide drives cerebral neuroinflammation by activating microglia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2012-12-18

    Assessing the temporal relationship between cognition and gait: slow gait predicts cognitive decline in the Mayo Clinic Study of Aging

    ✓ Peer-reviewed Risk factors The journals of gerontology. Series A, Biological sciences and medical sciences

    Key finding: Our study suggests that slow gait precedes cognitive decline. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2012-12-16

    The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit

    ✓ Peer-reviewed Vascular contributions Nature neuroscience

    Key finding: Single microinfarcts, targeted to encompass all or part of a cortical column, impaired performance in a macrovibrissa-based behavioral task. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2012-12-16

    Religion, spirituality, and health: the research and clinical implications

    ✓ Peer-reviewed Risk factors ISRN psychiatry

    Key finding: Next, I review research on R/S and health behaviors such as physical activity, cigarette smoking, diet, and sexual practices, followed by a review of relationships between R/S and heart disease, hypertension, cerebrovascular disease, Alzheimer's disease and dementia, immune functions, endocrine functions, cancer, overall mortality, physical disability, pain, and somatic symptoms.

    Full summary, score breakdown and related studies → Original source

  6. 2012-12-15

    Identifying patients with chronic conditions in need of palliative care in the general population: development of the NECPAL tool and preliminary prevalence rates in Catalonia

    ✓ Peer-reviewed End-of-life care BMJ supportive & palliative care

    Key finding: The focus is on development of the NECPAL tool to identify patients in need of PC; preliminary results of the NECPAL prevalence study, which assessed prevalence of advanced chronically ill patients within the population and all socio-health settings of Osona; and initial implementation of the NECPAL Programme in the region. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2012-12-14

    Cross-cultural differences in dementia: the Sociocultural Health Belief Model

    ✓ Peer-reviewed Disparities International psychogeriatrics

    Key finding: The SHBM provides an empirically based conceptual framework for examining cross-cultural differences in dementia care-seeking among diverse groups. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2012-12-12

    Frailty syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Aging

    ✓ Peer-reviewed Clinical safety Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: In our large population-based sample, frailty syndrome was a short-term predictor of overall dementia and VaD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2012-12-12

    Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia

    ✓ Peer-reviewed Caregiving Neurology

    Key finding: At baseline measurements, amyloid burden does not distinguish between cognitively impaired and unimpaired subjects with PD without dementia, but our data suggest that amyloid contributes to cognitive, but not motor, decline over time. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2012-12-11

    Potential benefits of adherence to the Mediterranean diet on cognitive health

    ✓ Peer-reviewed Prevention trials The Proceedings of the Nutrition Society

    Key finding: The purpose of this review was to update available knowledge on the relationship between adherence to the Mediterranean diet (MeDi) and cognitive decline, risk of dementia or Alzheimer's Disease (AD), and to analyse the reasons for some inconsistent results across studies. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2012-12-10

    Feelings of loneliness, but not social isolation, predict dementia onset: results from the Amsterdam Study of the Elderly (AMSTEL)

    ✓ Peer-reviewed Getting a diagnosis Journal of neurology, neurosurgery, and psychiatry

    Key finding: Feeling lonely rather than being alone is associated with an increased risk of clinical dementia in later life and can be considered a major risk factor that, independently of vascular disease, depression and other confounding factors, deserves clinical attention. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2012-12-08

    Association of GWAS‐linked loci with late‐onset Alzheimer's disease in a northern Han Chinese population

    ✓ Peer-reviewed Genetics Alzheimer s & Dementia

    Key finding: In a multivariate analysis, associations of MS4A6A (rs610932; odds ratio = 0.632, Bonferroni corrected P = .019) and CD33 (rs3865444; odds ratio = 1.492, Bonferroni corrected P = .017) with LOAD were replicated successfully. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2012-12-08

    Brain size and the compensation of Alzheimer's disease symptoms: a longitudinal cohort study

    ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Greater intracranial volume (ICV) has been associated with less severe Alzheimer's disease (AD) symptoms at a given level of cerebral pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2012-12-08

    Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaints

    ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Low Aβ42 was the strongest predictor of clinical progression in patients with subjective complaints. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2012-12-07

    Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls

    ✓ Peer-reviewed Risk genes beyond APOE Annals of neurology

    Key finding: Although amyloid-beta (Aβ) peptide deposition into insoluble plaques is a pathological hallmark of Alzheimer disease; soluble oligomeric Aβ has been hypothesized to more directly underlie impaired learning and memory in dementia of the Alzheimer type. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2012-12-06

    Apolipoprotein e sets the stage: response to injury triggers neuropathology

    ✓ Peer-reviewed Genetics Neuron

    Key finding: Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease and is associated with poor clinical outcome following traumatic brain injury and other neuropathological disorders.

    Full summary, score breakdown and related studies → Original source

  17. 2012-12-06

    Microglia, amyloid, and glucose metabolism in Parkinson's disease with and without dementia

    ✓ Peer-reviewed Cognitive tests and assessment Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    Key finding: We hypothesize that microglial activation is an early event in the Parkinson's disease (PD) spectrum and is independent of the amyloid pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2012-12-06

    Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Acta neuropathologica

    Key finding: Studies from families with ADAD have been critical to support the amyloid cascade hypothesis of Alzheimer disease (AD), the basis for the current development of amyloid-based disease-modifying therapies in sporadic AD (SAD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2012-12-05

    Maturation of autophagosomes and endosomes: a key role for Rab7

    ✓ Peer-reviewed Brain scans and imaging Biochimica et biophysica acta

    Key finding: The point where autophagosomes and endosomes fuse with lysosomes to permit for the final degradation of their contents is important. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2012-12-03

    Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of clinical investigation

    Key finding: Aβ is generated from sequential cleavages of the β-amyloid precursor protein (APP) by the β- and γ-secretases, and β-site APP-cleaving enzyme 1 (BACE1) is the β-secretase essential for Aβ generation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2012-12-03

    Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia

    ✓ Peer-reviewed Risk factors Cardiovascular psychiatry and neurology

    Key finding: Evidence also suggests that a neuronal energy crisis brought on by relentless brain hypoperfusion may be responsible for protein synthesis abnormalities that later result in the classic neurodegenerative lesions involving the formation of amyloid-beta plaques and neurofibrillary tangles.

    Full summary, score breakdown and related studies → Original source

  22. 2012-12-02

    The spectrum of disease in chronic traumatic encephalopathy

    ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

    Key finding: The frequent association of chronic traumatic encephalopathy with other neurodegenerative disorders suggests that repetitive brain trauma and hyperphosphorylated tau protein deposition promote the accumulation of other abnormally aggregated proteins including TAR DNA-binding protein 43, amyloid beta protein and alpha-synuclein.

    Full summary, score breakdown and related studies → Original source

  23. 2012-12-01

    REMCARE: reminiscence groups for people with dementia and their family caregivers – effectiveness and cost-effectiveness pragmatic multicentre randomised trial

    ⚠ Report — not peer-reviewed Costs and economics Health Technology Assessment

    Key finding: The intention-to-treat analysis identified no differences in outcome between the intervention and control conditions on primary or secondary outcomes [self-reported quality of life in Alzheimer's disease: mean difference 0.07, standard error (SE) 0.65; F = 0.48; p = 0.53]. +4 more findings

    Scored 52 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  24. 2012-12-01

    Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

    ✓ Peer-reviewed Risk factors Lancet (London, England)

    Key finding: Ischaemic heart disease and stroke collectively killed 12·9 million people in 2010, or one in four deaths worldwide, compared with one in five in 1990; 1·3 million deaths were due to diabetes, twice as many as in 1990. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2012-12-01

    Risk factors for falls in HIV-infected persons

    ✓ Peer-reviewed Clinical safety Journal of acquired immune deficiency syndromes (1999)

    Key finding: Middle-aged HIV-infected adults have high fall risk. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →