Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,801–18,825 of 27,380 studies, newest first · page 753 of 1096.
March 2013 25
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2013-03-19
The lived experience of family caregivers who provided end-of-life care to persons with advanced dementia
36/100 ✓ Peer-reviewed End-of-life care Palliative & supportive care
Key finding: Further findings are organized according to the existential life worlds. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-19
Pain and hospice care in nursing home residents with dementia and terminal cancer
55/100 ✓ Peer-reviewed End-of-life care Geriatrics & gerontology international
Key finding: Preliminary results suggest that hospice enrolment might be influenced by the facility or region of this particular country. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-18
Risk Factors for β-Amyloid Deposition in Healthy Aging
50/100 ✓ Peer-reviewed Brain scans and imaging JAMA Neurology
Key finding: Participants in the hypertension group with at least 1 ε4 allele showed significantly greater amyloid burden than those with only 1 risk factor or no risk factors. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-18
Changes in cognition and behaviour in amyotrophic lateral sclerosis: nature of impairment and implications for assessment
52/100 ✓ Peer-reviewed Lewy body dementia The Lancet. Neurology
Key finding: Deficits are characterised by executive and working-memory impairments, extending to changes in language and social cognition. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-17
Causes of hospital admission for people with dementia: a systematic review and meta-analysis
64/100 ✓ Peer-reviewed Clinical safety Journal of the American Medical Directors Association
Key finding: Many older people's crisis teams tend to focus on prevention and reducing psychiatric admissions. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-15
Atrophy rates in asymptomatic amyloidosis: implications for Alzheimer prevention trials
43/100 ✓ Peer-reviewed Biomarkers PloS one
Key finding: Cortical β-amyloid plaques, the first stage of AD pathology, can be detected in vivo using positron emission tomography (PET), and several studies have shown that ~1/3 of healthy elderly have significant β-amyloid deposition. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-14
Contemporary prevalence and correlates of incident heart failure with preserved ejection fraction
53/100 ✓ Peer-reviewed Disparities The American journal of medicine
Key finding: Compared with white patients, black patients were less likely to have heart failure with preserved systolic function. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-13
Disruption of cerebral networks and cognitive impairment in Alzheimer disease
46/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: The structural brain network of patients showed reduced local efficiency compared to controls. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-03-13
Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration
43/100 ✓ Peer-reviewed Genetics The American journal of pathology
Key finding: Compared with neurons cultured alone, intraneuronal Aβ content was significantly increased in neurons co-cultured with wild-type but not with ApoE knockout (KO) astrocytes. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-12
New therapies for treating Down syndrome require quality of life measurement
33/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics. Part A
Key finding: Down syndrome (DS) is the most common genetic cause of cognitive deficits. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-12
Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment
57/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology
Key finding: Parietal and occipital lobar CMBs counts were higher in PiB(+) ADCI with moderate WMH than PiB(+) ADCI with minimal WMH, whereas PiB(-) patients with SVCI (ie, "pure" SVCI) showed both lobar and deep CMBs. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-11
Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model
40/100 ✓ Peer-reviewed Drug development PloS one
Key finding: A significant increase was observed with chronically treated 6, 12, 15 month APP/PS1 and WT groups. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-03-08
Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker
50/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy
Key finding: Based on our review of the current literature on plasma Aβ, we conclude that further clinical research and assay development are needed before measures of plasma Aβ can be interpreted so they can be applied as trait, risk or state biomarkers for AD.
Full summary, score breakdown and related studies → Original source
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2013-03-08
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
74/100 ✓ Peer-reviewed Caregiving The Lancet. Neurology
Key finding: At baseline, significantly higher Aβ burdens were noted in patients with AD (2·27, SD 0·43) and those with MCI (1·94, 0·64) than in healthy controls (1·38, 0·39).
Full summary, score breakdown and related studies → Original source
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2013-03-08
Efficacy of cognitive rehabilitation therapies for mild cognitive impairment (MCI) in older adults: working toward a theoretical model and evidence-based interventions
48/100 ✓ Peer-reviewed Prevention and risk Neuropsychology review
Key finding: Our review revealed a need for evidence-based treatments for MCI and a lack of a theoretical rehabilitation model to guide the development and evaluation of these interventions. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-07
A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer's disease
36/100 ✓ Peer-reviewed Treatments The primary care companion for CNS disorders
Key finding: AChE-selective inhibitors and a dual AChE and BuChE inhibitor demonstrate symptomatic efficacy in AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-03-07
Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems
40/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy
Key finding: Companion reviews in Alzheimer's Research & Therapy will review specific types of biomarkers or applications; in this overview, we cover key concepts related to AD blood biomarker studies in general. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-07
Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder
57/100 ✓ Peer-reviewed Risk factors Sleep medicine
Key finding: In this large series of PSG-confirmed and probable RBD cases that underwent autopsy, the strong association of RBD with the synucleinopathies was further substantiated and a wider spectrum of disorders which can underlie RBD now are more apparent. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-03-06
The triggering receptor expressed on myeloid cells 2: "TREM-ming" the inflammatory component associated with Alzheimer's disease
38/100 ✓ Peer-reviewed TREM2 and immune genetics Oxidative medicine and cellular longevity
Key finding: Recently, a novel variant in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has been identified that has refocused the spotlight back onto inflammation as a major contributing factor in AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-06
Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease
41/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of nutrition
Key finding: This study aimed to determine whether a dietary intervention could attenuate microgliosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-03-06
Prion-like spreading of pathological α-synuclein in brain
56/100 ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology
Key finding: Immunoblot analysis demonstrated that endogenous mouse α-synuclein started to accumulate 3 months after inoculation, while injected human α-synuclein fibrils disappeared in about a week. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-03-06
The changing scene of amyotrophic lateral sclerosis
50/100 ✓ Peer-reviewed Lewy body dementia Nature reviews. Neuroscience
Key finding: In addition, these breakthroughs have revealed mechanistic links between ALS and frontotemporal dementia, as well as between ALS and other neurodegenerative diseases, such as the cerebellar atrophies, myotonic dystrophy and inclusion body myositis.
Full summary, score breakdown and related studies → Original source
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2013-03-06
Adipose tissue dysfunction contributes to obesity related metabolic diseases
46/100 ✓ Peer-reviewed Risk factors Best practice & research. Clinical endocrinology & metabolism
Key finding: Obesity significantly increases the risk of developing type 2 diabetes, hypertension, coronary heart disease, stroke, fatty liver disease, dementia, obstructive sleep apnea and several types of cancer.
Full summary, score breakdown and related studies → Original source
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2013-03-06
Screening for predementia AD: time-dependent operating characteristics of episodic memory tests
53/100 ✓ Peer-reviewed Genetics Neurology
Key finding: For follow-up intervals of 2-4 years, the FCSRT-FR is more predictive than the LM-IR for identifying individuals with memory complaints who will develop incident AD.
Full summary, score breakdown and related studies → Original source
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2013-03-05
Precipitating and predisposing events and symptoms for admission to assisted living or nursing home care
55/100 ✓ Peer-reviewed Health systems and care delivery Canadian geriatrics journal : CGJ
Key finding: Of 353 people admitted during the enrolment period, 174 (49%) took part in the survey. +4 more findings
Full summary, score breakdown and related studies → Original source
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