Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,801–12,825 of 27,380 studies, newest first · page 513 of 1096.
May 2019 25
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2019-05-30
Caregiver preparedness for death in dementia: an evaluation of existing tools
39/100 ✓ Peer-reviewed End-of-life care Aging & mental health
Key finding: Authors extracted 569 tools from articles, retaining seven tools for evaluation. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-30
Palliative Care in the Hip Fracture Patient
41/100 ✓ Peer-reviewed End-of-life care Geriatric orthopaedic surgery & rehabilitation
Key finding: Evaluation of each patient using a variety of decision making tools should help the orthopedic surgeon determine which patients would be better suited to non-operative management.
Full summary, score breakdown and related studies → Original source
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2019-05-30
End-of-life experiences in dementia with Lewy bodies: Qualitative interviews with former caregivers
41/100 ✓ Peer-reviewed End-of-life care PloS one
Key finding: Study results emphasize the need for improved EOL counseling in DLB, recognition of EOL symptoms, earlier hospice involvement, tailoring EOL care to DLB-specific needs, and clinician-family communication. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-30
Cognitive and neural plasticity in old age: A systematic review of evidence from executive functions cognitive training
66/100 ✓ Peer-reviewed Prevention trials Ageing research reviews
Key finding: This systematic review examined the effects of executive functions training on brain and cognition amongst healthy older adults across 20 studies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-30
Vitamin D and the nervous system
45/100 ✓ Peer-reviewed Brain scans and imaging Neurological research
Key finding: the studies reviewed show that VD contributes to cerebral activity in both embryonic and adult brain, helping the connectivity of neural circuits responsible for locomotor, emotional and reward-dependent behavior. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-29
Prevalence of idiopathic normal pressure hydrocephalus: A prospective, population-based study
53/100 ✓ Peer-reviewed Digital health tools PloS one
Key finding: In this prospective, population-based study the prevalence of iNPH was 3.7% among individuals 65 years and older, and more common in the higher age group, 80 years and above. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-29
Orthostatic hypotension and REM sleep behaviour disorder: impact on clinical outcomes in α-synucleinopathies
66/100 ✓ Peer-reviewed Clinical safety Journal of neurology, neurosurgery, and psychiatry
Key finding: OH and RBD yielded individual and combined negative effects on disability in α-synucleinopathies, reflecting a 'malignant' phenotype of PD with early cognitive impairment and postural instability. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-29
Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin
81/100 ✓ Peer-reviewed Risk factors Gastroenterology
Key finding: In a large placebo-controlled randomized trial, we found that pantoprazole is not associated with any adverse event when used for 3 years, with the possible exception of an increased risk of enteric infections. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-29
CNS small vessel disease: A clinical review
57/100 ✓ Peer-reviewed How common it is Neurology
Key finding: Pathogenesis is thought to begin with an etiologically specific insult, with or without genetic predisposition, which results in dysfunction of the neurovascular unit.
Full summary, score breakdown and related studies → Original source
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2019-05-29
The association between subjective caregiver burden and depressive symptoms in carers of older relatives: A systematic review and meta-analysis
72/100 ✓ Peer-reviewed Caregiving PloS one
Key finding: Subjective caregiver burden is a significant risk factor for depressive symptoms in carers of older people and may precipitate clinical depression. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-28
Glia-specific autophagy dysfunction in ALS
39/100 ✓ Peer-reviewed Disease mechanisms Seminars in cell & developmental biology
Key finding: Therefore, autophagy is considered a critical ND-protective pathway, which opens up potential new therapeutic interventions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-28
Risk Factor Variability and Cardiovascular Outcome: JACC Review Topic of the Week
39/100 ✓ Peer-reviewed Risk factors Journal of the American College of Cardiology
Key finding: Variability of these risk factors has been demonstrated to be a powerful predictor for all-cause and cardiovascular mortality, stroke, coronary artery disease, heart failure, end-stage renal disease, and dementia.
Full summary, score breakdown and related studies → Original source
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2019-05-28
Effects of functional communication interventions for people with primary progressive aphasia and their caregivers: a systematic review
57/100 ✓ Peer-reviewed Digital health tools Aging & mental health
Key finding: There are variations in the interventions, such as location and dosage. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-27
Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation
39/100 ✓ Peer-reviewed Genetics FEBS letters
Key finding: Apolipoprotein E (APOE) genotype determines Alzheimer's disease (AD) susceptibility, with the APOE ε4 allele being an established risk factor for late-onset AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-27
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
61/100 ✓ Peer-reviewed Long-term cohort studies Acta neuropathologica
Key finding: The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-27
TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling
37/100 ✓ Peer-reviewed TREM2 and immune genetics Neurochemical research
Key finding: The triggering receptor expressed on myeloid cells 2 (TREM2) gene is associated with the pathogenesis of LOAD and plays important roles in mediating the phagocytosis of Aβ by microglia and regulating inflammation in central nervous system. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-26
Relationship of traumatic brain injury to chronic mental health problems and dementia in military veterans
42/100 ✓ Peer-reviewed TREM2 and immune genetics Neuroscience letters
Key finding: The conflicts in Iraq and Afghanistan have increased public awareness of TBI in the military. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-24
Using Technology to Facilitate Fidelity Assessments: The Tele-STAR Caregiver Intervention
46/100 ✓ Peer-reviewed Caregiving Journal of medical Internet research
Key finding: Tele-STAR reduced caregiver burden and retained good program and treatment fidelity to STAR-C. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-24
Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment
55/100 ✓ Peer-reviewed Genetics Translational psychiatry
Key finding: Increases in average PRS scores across diagnosis group were observed with one-way ANOVA suggesting significant differences in PRS between the groups (p < 0.0001). +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-24
Chenodeoxycholic Acid Ameliorates AlCl 3 -Induced Alzheimer's Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats
43/100 ✓ Peer-reviewed Drug development Molecules (Basel, Switzerland)
Key finding: Chenodeoxycholic acid (CDCA) and synthetic Farnesoid X receptor (FXR) ligands have shown promising outcomes in ameliorating insulin resistance associated with various medical conditions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-24
Moving beyond 'safety' versus 'autonomy': a qualitative exploration of the ethics of using monitoring technologies in long-term dementia care
44/100 ✓ Peer-reviewed Digital health tools BMC geriatrics
Key finding: There is an urgent need for greater consideration of the ethical and legal implications that remote technological monitoring might have upon workforce morale, recruitment and retention.
Full summary, score breakdown and related studies → Original source
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2019-05-22
Antibiotics, gut microbiota, and Alzheimer's disease
41/100 ✓ Peer-reviewed Disease mechanisms Journal of neuroinflammation
Key finding: Recently, it has been hypothesized that AD may be associated with a dysbiosis of microbes in the intestine. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-22
End of life care for long-term care residents with dementia, chronic illness and cancer: prospective staff survey
50/100 ✓ Peer-reviewed End-of-life care BMC geriatrics
Key finding: Overall, symptoms in the last week and month of life did not vary by diagnosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-22
Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling
41/100 ✓ Peer-reviewed Disease mechanisms The EMBO journal
Key finding: We have recently shown that amyloid-β, the second hallmark of AD, induces de novo protein synthesis of tau. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-22
The escalating global burden of serious health-related suffering: projections to 2060 by world regions, age groups, and health conditions
54/100 ✓ Peer-reviewed Caregiving The Lancet. Global health
Key finding: By 2060, an estimated 48 million people (47% of all deaths globally) will die with serious health-related suffering, which represents an 87% increase from 26 million people in 2016. 83% of these deaths will occur in low-income and middle-income countries. +2 more findings
Full summary, score breakdown and related studies → Original source
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