Home › Research › Treatments
Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease
Dar-Nimrod I, Chapman BP, Franks P, Robbins J, Porsteinsson A, Mapstone M, Duberstein PR.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2012-12-01
Topic: Amyloid, tau and blood-test diagnosis
Objectives We tested the hypothesis that neuroticism moderates the association between APOE (apolipoprotein E) genotype and two major outcomes, cognitive function and Alzheimer disease. We also explored whether other personality dimensions (extraversion, openness to experience, agreeableness, and conscientiousness) moderate the associations of APOE with these outcomes. Design Primary analyses of existing randomized clinical trial data. Sample Six-hundred two older adults (mean age of 78 years at baseline). Measurements APOE genotype, the NEO-Five Factor Inventory, the Alzheimer's Disease Assessment Scale-Cognitive: measured every 6 months for 6.5 years) and relevant covariates. Results Fully adjusted multivariate analyses showed that the association between the presence of APOE [Latin Small Letter Open E]-4 allele(s) and both outcomes was evident among individuals with high levels of neuroticism and extraversion but not among persons with low levels of these traits. Conclusions Phenotypic personality dimensions, primarily neuroticism and extraversion, moderate the relationship between APOE [Latin Small Letter Open E]-4 genotype and cognitive outcomes among older adults. Future research is needed to elucidate the physiological processes involved in these particular phenotype-genotype interactions.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Dar-Nimrod, I., Chapman, B. P., Franks, P., Robbins, J., Porsteinsson, A., Mapstone, M., et al. (2012). Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. https://doi.org/10.1097/jgp.0b013e318267016b
Vancouver
Dar-Nimrod I, Chapman BP, Franks P, Robbins J, Porsteinsson A, Mapstone M, et al. Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2012. doi:10.1097/jgp.0b013e318267016b. PMID: 23079898.
BibTeX
@article{darnimrod2012-23079898,
author = {Dar-Nimrod, I. and Chapman, B. P. and Franks, P. and Robbins, J. and Porsteinsson, A. and Mapstone, M. and Duberstein, P. R.},
title = {{Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease}},
journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
year = {2012},
doi = {10.1097/jgp.0b013e318267016b},
pmid = {23079898},
url = {https://doi.org/10.1097/jgp.0b013e318267016b}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Results Fully adjusted multivariate analyses showed that the association between the presence of APOE [Latin Small Letter Open E]-4 allele(s) and both outcomes was evident among individuals with high levels of neuroticism and extraversion but not among persons with low levels of these traits.
Why it matters
In 602 older adults, the link between carrying the APOE ε4 allele and both cognitive function and Alzheimer disease was evident among those with high levels of neuroticism and extraversion but not among those with low levels of these traits. The authors call for future research to clarify the biological processes behind these personality-genotype interactions.
New to this subject? Start with our plain-English guide: Treatments →
Study details
- Effect sizeor 6.5
- Evidence strengthHigh
How this study scored 58/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for sample size because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry) |
| Journal's citation record | 2 / 4 | American Journal of Geriatric Psychiatry: journal h-index 178 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2012 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 4 / 7 | Cited 40 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.5 citations a year over 16 year(s) since 2012 |
| Impact for its field and year | 2 / 6 | Cited 1.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Paul R. Duberstein: h-index 86 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The University of Sydney: institution h-index 1,466 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23079898) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1097/jgp.0b013e318267016b
- PubMed: 23079898
- Original source →
- Free full text: PubMed Central →
Full text: free to read — PubMed Central lists this copy as free to read: the link above (checked 10 Oct 2026).
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 13.
Related studies in Treatments
Also tagged “precursor”
1,339 studies in the library carry the topic tag “precursor”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,339 tagged studies.