Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 21,551–21,575 of 27,380 studies, newest first · page 863 of 1096.
March 2009 25
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2009-03-20
Comparison of Abeta levels in the brain of familial and sporadic Alzheimer's disease
36/100 ✓ Peer-reviewed Biomarkers Neurochemistry international
Key finding: We found similar levels of soluble Abeta42, insoluble and soluble Abeta40 in both APPsw mutation carriers and SAD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-19
Fall risk factors in older people with dementia or cognitive impairment: a systematic review
64/100 ✓ Peer-reviewed Clinical safety Journal of advanced nursing
Key finding: There is lack of sound studies examining fall risk factors in cognitively impaired elders.
Full summary, score breakdown and related studies → Original source
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2009-03-19
Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
67/100 ✓ Peer-reviewed Biomarkers Annals of Neurology
Key finding: CSF A beta(1-42) was the most sensitive biomarker for AD in the autopsy cohort of CSF samples: receiver operating characteristic area under the curve of 0.913 and sensitivity for AD detection of 96.4%. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-19
A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
52/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neurochemistry
Key finding: Prior evidence indicates triggering receptor expressed by myeloid cells-2 (TREM2) promotes phagocytosis and retards inflammation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-18
The clinical profile of right temporal lobe atrophy
59/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology
Key finding: Frontotemporal lobar degeneration is currently associated with three syndromic variants. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-17
Urban air pollution: influences on olfactory function and pathology in exposed children and young adults
40/100 ✓ Peer-reviewed Risk factors Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
Key finding: MC subjects had significantly lower UPSIT scores: 34.24+/-0.42 versus controls 35.76+/-0.40, p=0.03. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-03-14
Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis
48/100 ✓ Peer-reviewed Mild cognitive impairment Acta neuropathologica
Key finding: In this review, we summarized our findings of redox proteomics identified oxidatively modified proteins in AD, MCI and AD models.
Full summary, score breakdown and related studies → Original source
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2009-03-13
Cognitive reserve
36/100 ✓ Peer-reviewed Risk factors Neuropsychologia
Key finding: The concept of reserve has been proposed to account for the disjunction between the degree of brain damage and its clinical outcome. +3 more findings
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2009-03-13
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
64/100 ✓ Peer-reviewed Risk factors Brain : a journal of neurology
Key finding: Mutations in the glucocerebrosidase gene (GBA) are associated with Gaucher's disease, the most common lysosomal storage disorder. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-12
Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study
55/100 ✓ Peer-reviewed Vascular contributions Diabetologia
Key finding: Uncontrolled diabetes increases the risk of Alzheimer's disease and VaD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-11
Caring for Aged Dementia Care Resident Study (CADRES) of person-centred care, dementia-care mapping, and usual care in dementia: a cluster-randomised trial
72/100 ✓ Peer-reviewed Clinical safety The Lancet. Neurology
Key finding: 15 care sites with 289 residents were randomly assigned. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-03-11
The role of tau in neurodegeneration
52/100 ✓ Peer-reviewed Lewy body dementia Molecular neurodegeneration
Key finding: Nonetheless, it is believed that tau-mediated neurodegeneration is likely to result from a combination of toxic gains of function as well as from the loss of normal tau function.
Full summary, score breakdown and related studies → Original source
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2009-03-11
Propagation of tau misfolding from the outside to the inside of a cell
54/100 ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry
Key finding: Finally, we observed that newly aggregated intracellular Tau transfers between co-cultured cells. +2 more findings
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2009-03-11
Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones
47/100 ✓ Peer-reviewed Genetics Journal of controlled release : official journal of the Controlled Release Society
Key finding: We have also demonstrated uptake of the albumin/ApoE nanoparticles into mouse endothelial (b.End3) cells in vitro and their intracellular localisation. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-03-09
Facilitating aerobic exercise training in older adults with Alzheimer's disease
38/100 ✓ Peer-reviewed Prevention trials Geriatric nursing (New York, N.Y.)
Key finding: Emerging science suggests that aerobic exercise might modify the pathophysiology of Alzheimer's disease (AD) and improve cognition. +2 more findings
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2009-03-09
Oxidative stress and metabolic syndrome
36/100 ✓ Peer-reviewed Disease mechanisms Life sciences
Key finding: Although there has been significant debate regarding the criteria and concept of the syndrome, this clustering of risk factors is unequivocally linked to an increased risk of developing type 2 diabetes and cardiovascular disease. +1 more finding
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2009-03-07
Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease
40/100 ✓ Peer-reviewed Risk genes beyond APOE Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Key finding: Retinal ganglion cell loss is considered to be a cause of visual impairment in Alzheimer;s patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-06
Delirium in the Nursing Home Setting
24/100 ✓ Peer-reviewed Health systems and care delivery Psychiatry in Long-Term Care
Key finding: Although extensively studied in the acute care setting, the syndrome of delirium— also referred to as acute confusion—has been a subject of relatively few studies in the long-term care (LTC) setting.
Full summary, score breakdown and related studies → Original source
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2009-03-06
Dementia in Nursing Home Patients: Assessment and Management
26/100 ✓ Peer-reviewed Health systems and care delivery Psychiatry in Long-Term Care
Key finding: Currently 4 million Americans suffer from dementia. +4 more findings
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2009-03-05
Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study
47/100 ✓ Peer-reviewed Hippocampus size on brain scans Stroke
Key finding: Carotid atherosclerosis markers were associated with MRI indices of brain ischemia and aging and with cognitive impairment in a community-based sample of middle-aged adults. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-05
Surrogate decision makers' understanding of dementia patients' prior wishes for end-of-life care
36/100 ✓ Peer-reviewed End-of-life care Journal of aging and health
Key finding: Most surrogates reported that patients had previously completed an advance directive (59%), discussed preferences for EOL care (56%), or done both (38%).
Full summary, score breakdown and related studies → Original source
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2009-03-05
Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain
40/100 ✓ Peer-reviewed Risk genes beyond APOE The American journal of pathology
Key finding: Here, we found that Abeta levels increased and amyloid precursor protein (APP) levels simultaneously decreased in hyperhomocysteinemic rats after a 2-week induction by vena caudalis injection of homocysteine. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
Glutathione dysregulation and the etiology and progression of human diseases
36/100 ✓ Peer-reviewed Disease mechanisms Biological chemistry
Key finding: Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and as a result, disturbances in GSH homeostasis are implicated in the etiology and/or progression of a number of human diseases, including cancer, diseases of aging, cystic fibrosis, and cardiovascular, inflammatory, immune, metabolic, and neurodegenerative diseases. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options
40/100 ✓ Peer-reviewed Disease mechanisms Current neuropharmacology
Key finding: Antioxidants are now being looked upon as persuasive therapeutic against solemn neuronal loss, as they have capability to combat by neutralizing free radicals. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
AMPK and the biochemistry of exercise: implications for human health and disease
36/100 ✓ Peer-reviewed Prevention trials The Biochemical journal
Key finding: We also discuss the potential role of AMPK activation in mediating the prevention and treatment by exercise of specific disorders associated with the metabolic syndrome, including Type 2 diabetes and Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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