Newest studies

Associations Between Ultra-Processed Food Consumption and Adverse Brain Health Outcomes

78/100 ✓ Peer-reviewed Prevention trials Neurology

Key finding: The cognitive impairment cohort (n = 14,175) included participants without evidence of impairment at baseline who underwent follow-up testing. +2 more findings

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Association of soluble TREM2 with Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis

57/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in aging neuroscience

Key finding: CSF sTREM2 levels are positively associated with an increased risk of AD and MCI. +4 more findings

• Early Stage
• Genetics
• Biomarkers

Full summary, score breakdown and related studies → Original source

A cross-sectional study of α-synuclein seed amplification assay in Alzheimer's disease neuroimaging initiative: Prevalence and associations with Alzheimer's disease biomarkers and cognitive function

56/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Alzheimer's disease (AD) pathology is defined by β-amyloid (Aβ) plaques and neurofibrillary tau, but Lewy bodies (LBs; 𝛼-synuclein aggregates) are a common co-pathology for which effective biomarkers are needed. +3 more findings

• Biomarkers
• Brain Biology

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Clinical Significance of the Plasma Biomarker Panels in Amyloid-Negative and Tau PET-Positive Amnestic Patients: Comparisons with Alzheimer's Disease and Unimpaired Cognitive Controls

39/100 ✓ Peer-reviewed Tau biomarkers International journal of molecular sciences

Key finding: In this multi-center study, we enrolled 285 subjects with young-onset AD (YOAD; n = 55), late-onset AD (LOAD; n = 96), TCP ( n = 44), and cognitively unimpaired controls (CTL; n = 90) and analyzed plasma Aβ42/Aβ40, pTau181, neurofilament light (NFL), and total-tau using single-molecule assays. +3 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Pharmacokinetic evaluation of donanemab for the treatment of Alzheimer's

43/100 ✓ Peer-reviewed Treatments Expert opinion on drug metabolism & toxicology

Key finding: Donanemab is a humanized monoclonal antibody that significantly reduces cerebral amyloid plaques in Alzheimer's Disease (AD). +2 more findings

• Treatments
• Side Effects

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Microglia, Trem2, and Neurodegeneration

46/100 ✓ Peer-reviewed TREM2 and immune genetics The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

Key finding: Microglia express Trem2, which serves as a receptor for a multitude of ligands enhancing their phagocytic activity. +3 more findings

• Genetics
• Brain Biology

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Sleep disturbances, cognitive decline, and AD biomarkers alterations in early Parkinson's disease

59/100 ✓ Peer-reviewed Risk factors Annals of clinical and translational neurology

Key finding: Baseline pRBD was associated with faster decline in global cognition and all cognitive domains, including verbal episodic memory, visuospatial ability, executive function, language, and processing speed. +4 more findings

• Biomarkers
• Lifestyle

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Diaminocyclopentane - l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase

43/100 ✓ Peer-reviewed Drug development Bioorganic chemistry

Key finding: The ease of their preparation, remarkable biological activities, stability, and non-toxicity make them promising candidates for the development of anti-tau-phosphorylation agents holding significant potential for the treatment of Alzheimer's disease.

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Long‐Term Mortality Predictors Using a Machine‐Learning Approach in Patients With Chronic Limb‐Threatening Ischemia After Peripheral Vascular Intervention

51/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Heart Association

Key finding: Patients with CLTI undergoing peripheral vascular intervention from 2017 to 2018 were derived from the Medicare-linked VQI (Vascular Quality Initiative) registry. +4 more findings

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Interprofessional collaboration in palliative dementia care

43/100 ✓ Peer-reviewed Health systems and care delivery Journal of interprofessional care

Key finding: The content analysis revealed three overall elements of these approaches: 1) collaborative themes, 2) collaborative processes, and 3) resources facilitating collaboration. +1 more finding

• End-of-Life Care

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A Comprehensive Review and Androgen Deprivation Therapy and Its Impact on Alzheimer's Disease Risk in Older Men with Prostate Cancer

45/100 ✓ Peer-reviewed End-of-life care Degenerative neurological and neuromuscular disease

Key finding: Recent research has shed light on a possible link between PCa and Alzheimer's disease (AD), which is a significant neurological ailment that affects older males all over the world. +1 more finding

• Treatments
• Brain Biology

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TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy

48/100 ✓ Peer-reviewed TREM2 and immune genetics Science immunology

Key finding: Reprogramming TAM by either blocking or deleting the macrophage receptor triggering receptor on myeloid cells 2 (TREM2) attenuates tumor growth, and lack of functional TREM2 enhances tumor elimination by anti-PD-1. +3 more findings

• Genetics

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Dementia in Rare Genetic Neurodevelopmental Disorders: A Systematic Literature Review

64/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurology

Key finding: Currently available literature shows limited information on aging in RGNDs, with relatively many reports of young-onset dementia. +1 more finding

• Genetics

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p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial

76/100 ✓ Peer-reviewed Treatments Nature medicine

Key finding: Within the prespecified secondary and exploratory outcome domains (structural magnetic resonance imaging, fluorodeoxyglucose positron-emission tomography and cerebrospinal fluid biomarkers), significant drug-placebo differences were found, consistent with the hypothesis that LM11A-31 slows progression of pathophysiological features of AD; no significant effect of active treatment was observed on cognitive tests. +1 more finding

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Risk of dementia with hearing impairment and social isolation

61/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: The combined hearing impairment and isolation with lack of conversation (hazard ratio: 1.69, 95% confidence interval: 1.09-2.61) and non-hearing impairment and isolation with lack of conversation (hazard ratio: 1.60, 95% confidence: 1.07-2.39) were associated with the development of dementia. +2 more findings

• Risk Factors

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APOE ε4 carrier status modifies plasma p-tau181 concentrations in cognitively healthy super-seniors

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Eighty (22%) participants were APOE ε4 carriers and 290 (73%) were non-carriers. +4 more findings

• Biomarkers
• Genetics

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Loneliness and social isolation among informal carers of individuals with dementia: A systematic review and meta-analysis

65/100 ✓ Peer-reviewed Caregiving International Journal of Geriatric Psychiatry

Key finding: This study underscores the substantial prevalence of loneliness and social isolation among informal carers of individuals with dementia. +2 more findings

• Lifestyle
• Caregiving

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Lithium Exposure and Risk of Major Neurocognitive Disorders: A Systematic Review and Meta-analysis

89/100 ✓ Peer-reviewed Drug development Journal of clinical psychopharmacology

Key finding: Eight studies with 377,060 subjects were included in the analysis. +4 more findings

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Alzheimer's disease pathophysiology in the Retina

43/100 ✓ Peer-reviewed Brain scans and imaging Progress in retinal and eye research

Key finding: Histological, biochemical, and clinical studies have demonstrated that the nature and severity of AD pathologies in the retina and brain correspond. +1 more finding

• Brain Biology

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Choriocapillaris reduction accurately discriminates against early-onset Alzheimer's disease

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Both cohorts revealed diminished choriocapillaris signals, demonstrating the highest discriminatory capability (area under the receiver operating characteristic curve: SS-OCTA 0.913, SD-OCTA 0.991; P < 0.001). +4 more findings

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Novel Biomarkers for Alzheimer's Disease: Plasma Neurofilament Light and Cerebrospinal Fluid

43/100 ✓ Peer-reviewed Biomarkers International journal of Alzheimer's disease

Key finding: Neurodegenerative disorders such as Alzheimer's disease (AD) represent an increasingly significant public health concern. +1 more finding

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome

43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Annals of neurology

Key finding: Our findings point to the involvement of increased levels of Aβ42 and/or Aβ40 in contributing to several molecular and cognitive traits associated with DS-AD. +3 more findings

• Down Syndrome
• Brain Biology

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Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting

50/100 ✓ Peer-reviewed Biomarkers Molecular neurodegeneration

Key finding: Recently, the blood-based AD biomarker field has seen significant progress driven by technological advances, mainly improved analytical sensitivity and precision of the assays and measurement platforms. +2 more findings

• Biomarkers

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Introduction to Large Language Models (LLMs) for dementia care and research

45/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in dementia

Key finding: Overall, this review corroborates the promising utilization of LLMs to positively impact dementia care by boosting cognitive abilities, enriching social interaction, and supporting caregivers. +1 more finding

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Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results

71/100 ✓ Peer-reviewed Long-term cohort studies Nature medicine

Key finding: PR006 is an investigational gene therapy delivering the granulin gene (GRN) using an adeno-associated virus serotype 9 (AAV9) vector. +3 more findings

• Clinical Trials
• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source