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47/100

✓ Peer-reviewed alzhub usefulness score 47 out of 100. Inflammation and the immune system

Topic: Brain proteins, microglia and lab models

Microinfarcts are a common clinical feature of the aging brain, particularly in patients with cognitive decline or vascular or Alzheimer's dementia. However, the natural history of these lesions remains largely unexplored. Here we describe a mouse (C57BL/6J) model of multiple diffuse microinfarcts induced by unilateral internal carotid artery injection of cholesterol crystals (40-70 μm).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Wang, M., Iliff, J. J., Liao, Y., Chen, M. J., Shinseki, M. S., Venkataraman, A., et al. (2012). Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts. The Journal of neuroscience : the official journal of the Society for Neuroscience. https://doi.org/10.1523/jneurosci.1860-12.2012

Vancouver

Wang M, Iliff JJ, Liao Y, Chen MJ, Shinseki MS, Venkataraman A, et al. Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012. doi:10.1523/jneurosci.1860-12.2012. PMID: 23238711.

BibTeX

@article{wang2012-23238711,
  author  = {Wang, M. and Iliff, J. J. and Liao, Y. and Chen, M. J. and Shinseki, M. S. and Venkataraman, A. and Cheung, J. and Wang, W. and others},
  title   = {{Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2012},
  doi     = {10.1523/jneurosci.1860-12.2012},
  pmid    = {23238711},
  url     = {https://doi.org/10.1523/jneurosci.1860-12.2012}
}

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Key findings

However, the natural history of these lesions remains largely unexplored.
Here we describe a mouse (C57BL/6J) model of multiple diffuse microinfarcts induced by unilateral internal carotid artery injection of cholesterol crystals (40-70 μm).
Microinfarcts were spread throughout the deep cortex, subcortical tissue, and hippocampus and were comprised of a core positive for CD68 (a marker for reactive microglia and macrophages), surrounded by large regions of glial fibrillary acidic protein-positive reactive astrogliosis.
Widespread reactive gliosis, including mislocalization of the astrocytic water channel aquaporin 4 persisted long after injury, recovering only after 1 month after stroke.

Why it matters

This study describes a mouse model of multiple small brain infarcts that produced cognitive deficits and delayed neuronal loss. It is animal research about vascular brain injury and does not test any treatment or prevention for Alzheimer's disease in people.

Study details

Evidence strengthLow

How this study scored 47/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journal of neuroscience : the official journal of the Society for Neuroscience)
Journal's citation record	4 / 4	Journal of Neuroscience: journal h-index 651 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2012 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Laboratory or animal study (title names “mouse”) — scores zero
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 183 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	11.4 citations a year over 16 year(s) since 2012
Impact for its field and year	3 / 6	Cited 3.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	2 / 4	Cited 43 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Maiken Nedergaard: h-index 156 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Rochester: institution h-index 1,195 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 23238711)
Free to read	0 / 2	Behind a paywall — scores zero
Total	47 / 100	—

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