Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 16,551–16,575 of 27,380 studies, newest first · page 663 of 1096.
November 2015 25
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2015-11-16
Observational, longitudinal study of delirium in consecutive unselected acute medical admissions: age-specific rates and associated factors, mortality and re-admission
53/100 ✓ Peer-reviewed Clinical safety BMJ open
Key finding: Delirium affected a fifth of acute medical admissions and a third of those aged ≥75 years, and was associated with increased mortality, institutionalisation and dependency, but not with increased risk of re-admission on follow-up. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-16
Frailty and Cognitive Function in Incident Hemodialysis Patients
61/100 ✓ Peer-reviewed Disparities Clinical journal of the American Society of Nephrology : CJASN
Key finding: At cohort entry, the mean age was 54.8 years (SD 13.3), 56.5% were men, and 72.8% were black. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-14
Two insular regions are differentially involved in behavioral variant FTD and nonfluent/agrammatic variant PPA
43/100 ✓ Peer-reviewed Digital health tools Cortex; a journal devoted to the study of the nervous system and behavior
Key finding: ROI analysis of bilateral insula showed that the left SPGI was significantly more atrophied in nfvPPA compared to bvFTD, while the bilateral ventral anterior and right dorsal anterior insula sub-regions were more atrophied in bvFTD than nfvPPA.
Full summary, score breakdown and related studies → Original source
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2015-11-12
Advance care planning for nursing home residents with dementia: policy vs. practice
40/100 ✓ Peer-reviewed Health systems and care delivery Journal of Advanced Nursing
Key finding: Nursing homes generally met three quarters of the pre-defined criteria for advance care planning policy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-11
Is it always Alzheimer's? Let's talk to our patients about "cardiocerebrovascular" prevention
38/100 ✓ Peer-reviewed Prevention and risk Aging clinical and experimental research
Key finding: Unlike Alzheimer's, vascular dementia can, in part, be prevented. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-11
A Systematic Review of Interventions to Change Staff Care Practices in Order to Improve Resident Outcomes in Nursing Homes
60/100 ✓ Peer-reviewed Clinical safety PloS one
Key finding: Changing staff practice in nursing homes is possible but complex. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-11-11
Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration
36/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neurochemistry
Key finding: The levels of GFAP in AD, DLB, and FTLD patients were significantly higher than those in the healthy control subjects. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-11
Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition
46/100 ✓ Peer-reviewed Long-term cohort studies European radiology
Key finding: The AddNeuroMed and ADNI cohorts were combined giving a total of 329 healthy controls, 421 mild cognitive impairment patients, and 286 Alzheimer's disease (AD) patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-10
Tau Immunotherapy
38/100 ✓ Peer-reviewed Drug development Neuro-degenerative diseases
Key finding: Some antibodies are readily taken up into neurons, whereas others are not. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-10
Neurodegenerative diseases: From available treatments to prospective herbal therapy
36/100 ✓ Peer-reviewed End-of-life care Neurochemistry international
Key finding: For these neurodegenerative diseases yet we have only palliative therapies and none of them significantly capable to slow down or halt the underlying pathology. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-11-10
Association of Dynapenia, Sarcopenia, and Cognitive Impairment Among Community-Dwelling Older Taiwanese
51/100 ✓ Peer-reviewed Cognitive tests and assessment Rejuvenation research
Key finding: This study aimed to evaluate the association between dynapenia, sarcopenia, and cognitive impairment among community-dwelling older people in Taiwan. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-10
Lifespan and Healthspan: Past, Present, and Promise
50/100 ✓ Peer-reviewed Disparities The Gerontologist
Key finding: Compressing morbidity or increasing the relative healthspan will require "delaying aging" or delaying the physiological change that results in disease and disability. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-11-09
Dietary Patterns and Risk of Dementia: a Systematic Review and Meta-Analysis of Cohort Studies
65/100 ✓ Peer-reviewed Prevention and risk Molecular neurobiology
Key finding: Low levels of vitamin D were associated with cognitive decline.
Full summary, score breakdown and related studies → Original source
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2015-11-09
A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation
48/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: This results in caspase-1-dependent pro-inflammatory cytokine maturation, as well as a special type of cell death, known as pyroptosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-06
Comorbidities of epilepsy: current concepts and future perspectives
56/100 ✓ Peer-reviewed Caregiving The Lancet. Neurology
Key finding: Preliminary evidence suggests that some conditions, such as depression and migraine, negatively affect seizure outcome and quality of life.
Full summary, score breakdown and related studies → Original source
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2015-11-05
Compression or expansion of dementia in Germany? An observational study of short-term trends in incidence and death rates of dementia between 2006/07 and 2009/10 based on German health insurance data
40/100 ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy
Key finding: This study provides evidence that the increase in dementia-free life years went together with an absolute compression of life years with dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-05
Delirium Screening: A Systematic Review of Delirium Screening Tools in Hospitalized Patients
64/100 ✓ Peer-reviewed Clinical safety The Gerontologist
Key finding: Thirty-one studies describing 21 delirium screening tools were included in the systematic review.
Full summary, score breakdown and related studies → Original source
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2015-11-05
The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy
40/100 ✓ Peer-reviewed Disease mechanisms PloS one
Key finding: Compared with vehicle-treated controls, rapamycin protected against the tau-induced neuronal loss, synaptotoxicity, reactive microgliosis and astrogliosis, and activation of innate neuroimmunity. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-11-05
18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease
46/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: (18)F-THK5351 is a useful PET tracer for the early detection of neurofibrillary pathology in AD patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-05
Partial-Volume Effect Correction Improves Quantitative Analysis of 18F-Florbetaben β-Amyloid PET Scans
54/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: In cohort 1, PVEC increased the effect on AD-versus-HC discrimination from a Cohen d value of 1.68 to 2.0 for composite SUVRs and from 0.04 to 1.04 for mesial temporal cortex SUVRs. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-11-04
Medications That Older Adults in Hospice Care in the United States Take, 2007
53/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: People continue to receive disease-focused therapies at the end of life rather than therapies exclusively for palliation of symptoms, suggesting that treatments may vary according to the person's primary diagnosis. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-11-04
Identification of the palliative phase in people with dementia: a variety of opinions between healthcare professionals
40/100 ✓ Peer-reviewed End-of-life care BMC palliative care
Key finding: The results of the study identified that professionals across Europe have different opinions regarding the time point when to consider a person with dementia in need of palliative care. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-11-04
Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons
70/100 ✓ Peer-reviewed Brain tissue and pathology Neurology
Key finding: We tested the hypothesis that cerebral amyloid angiopathy (CAA) is related to Alzheimer disease (AD) dementia and decline in multiple cognitive systems in old age, independent of AD plaque and tangle pathology and other common age-related neuropathologies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-04
Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model
51/100 ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica
Key finding: It is commonly assumed that these deficits arise due to β-amyloid accumulation and plaque deposition. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-11-04
Raloxifene for women with Alzheimer disease: A randomized controlled pilot trial
67/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Classification of evidence This study provides Class I evidence that for women with AD, raloxifene does not have a significant cognitive effect. +4 more findings
Full summary, score breakdown and related studies → Original source
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