Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,926–18,950 of 27,380 studies, newest first · page 758 of 1096.
January 2013 25
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2013-01-22
Eye movements in patients with neurodegenerative disorders
36/100 ✓ Peer-reviewed Brain scans and imaging Nature reviews. Neurology
Key finding: The neural pathways and brain regions involved in eye movements during ocular fixation and gaze control include the cerebrum, brainstem and cerebellum, and abnormal eye movements can indicate the presence of neurodegeneration.
Full summary, score breakdown and related studies → Original source
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2013-01-22
Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series
56/100 ✓ Peer-reviewed Getting a diagnosis Sleep medicine
Key finding: The vast majority of men > or =50 years old initially diagnosed with iRBD in this study eventually developed a parkinsonian disorder/dementia, often after a prolonged interval from onset of iRBD, with the mean interval being 14 years while the range extended to 29 years. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-21
GDNF, NGF and BDNF as therapeutic options for neurodegeneration
36/100 ✓ Peer-reviewed Vascular contributions Pharmacology & therapeutics
Key finding: Preclinical results using BDNF also show much promise, although there are accompanying difficulties. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-21
Hearing Loss and Cognitive Decline in Older Adults
57/100 ✓ Peer-reviewed Risk factors JAMA Internal Medicine
Key finding: Hearing loss is independently associated with accelerated cognitive decline and incident cognitive impairment in community-dwelling older adults. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-20
Effects of the NYU caregiver intervention-adult child on residential care placement
71/100 ✓ Peer-reviewed Caregiving The Gerontologist
Key finding: Two thirds (66%) of adult child caregivers in the control condition admitted their parent to a residential care setting compared with 37% in the treatment condition. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-18
Designing a trial to evaluate potential treatments for apathy in dementia: the apathy in dementia methylphenidate trial (ADMET)
59/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: The design decisions made for ADMET are important elements to be considered in trials assessing the safety and efficacy of medications for clinically significant apathy in Alzheimer disease.
Full summary, score breakdown and related studies → Original source
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2013-01-17
Haloperidol prophylaxis in critically ill patients with a high risk for delirium
76/100 ✓ Peer-reviewed Clinical safety Critical care (London, England)
Key finding: Our evaluation study suggests that prophylactic treatment with low dose haloperidol in critically ill patients with a high risk for delirium probably has beneficial effects. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-17
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity
40/100 ✓ Peer-reviewed Clinical safety PLoS genetics
Key finding: Studies on protein methyltransferases have revealed that the regulatory function of methylation is not limited to epigenetics, with many non-histone substrates now being discovered. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-17
The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): study design and progress
76/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The FINGER is at the forefront of international collaborative efforts to solve the clinical and public health problems of early identification of individuals at increased risk of late-life cognitive impairment, and of developing intervention strategies to prevent or delay the onset of cognitive impairment and dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-16
Dementia Knowledge Assessment Tool Version Two: development of a tool to inform preparation for care planning and delivery in families and care staff
36/100 ✓ Peer-reviewed End-of-life care Dementia (London, England)
Key finding: Validity was supported by higher scores in professional versus nonprofessional staff and following the education.
Full summary, score breakdown and related studies → Original source
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2013-01-16
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
64/100 ✓ Peer-reviewed Biomarkers The Lancet Neurology
Key finding: Evidence has accumulated that supports the major assumptions of the 2010 hypothetical model of major biomarkers of Alzheimer's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-16
Obesity and impaired cognitive functioning in the elderly: a population-based cross-sectional study (NEDICES)
44/100 ✓ Peer-reviewed Cognitive tests and assessment European journal of neurology
Key finding: Studies of high body mass index (BMI) and cognition in the elderly have shown conflicting results. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-16
Clinicopathologic differences among patients with behavioral variant frontotemporal dementia
48/100 ✓ Peer-reviewed Digital health tools Neurology
Key finding: During life, patients with AD pathology may be misdiagnosed with bvFTD if they have an early age at onset and prominent neuropsychiatric features despite having greater memory difficulties and more intact personality and executive functions than patients with bvFTD-FTLD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-15
Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology
47/100 ✓ Peer-reviewed Inflammation and the immune system Proceedings of the National Academy of Sciences of the United States of America
Key finding: The pathogenesis of this neurodegenerative disease, currently without curative treatment, is associated with the accumulation of amyloid β (Aβ) in brain parenchyma and cerebral vasculature. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-11
Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity
38/100 ✓ Peer-reviewed Treatments Brain and behavior
Key finding: In agreement with previous findings, we found that memantine was fully effective in reversing NMDA toxicity at concentrations of 2.5 and 5 μmol/L. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-11
Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
36/100 ✓ Peer-reviewed Drug development Biochimica et biophysica acta
Key finding: Despite the limited knowledge on the molecular mechanisms and the etiological complexity of both pathologies, evidence suggests that neurodegeneration/death underlying cognitive dysfunction (and ultimately dementia) upon long-term T2D may arise from a complex interplay between T2D and brain aging. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-11
Impaired long distance functional connectivity and weighted network architecture in Alzheimer's disease
53/100 ✓ Peer-reviewed Mild cognitive impairment Cerebral cortex (New York, N.Y. : 1991)
Key finding: We found that patients had reduced amplitude and regional homogeneity of low-frequency fMRI oscillations, and reduced the strength of functional connectivity, in several regions previously described as components of the default mode network, for example, medial posterior parietal cortex and dorsal medial prefrontal cortex. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-11
Type 2 diabetes as a risk factor for Alzheimer's disease: the confounders, interactions, and neuropathology associated with this relationship
68/100 ✓ Peer-reviewed Risk factors Epidemiologic reviews
Key finding: Fourteen studies reported positive associations, of which 9 were statistically significant. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-11
Neuropsychological correlates of capacity determinations in Alzheimer disease: implications for assessment
45/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: How experienced psychiatrists view the capacity of patients with Alzheimer disease for consenting to research and for appointing a proxy may be related to the patients' conceptualization and memory functioning.
Full summary, score breakdown and related studies → Original source
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2013-01-10
Palliative care provision in the emergency department: barriers reported by emergency physicians
36/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: We identify two main ED physician-perceived barriers to PC provision: lack of access to medical records and lack of 24/7 availability of PC team.
Full summary, score breakdown and related studies → Original source
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2013-01-09
Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome
52/100 ✓ Peer-reviewed Caregiving Alzheimer's research & therapy
Key finding: For example, focal temporal lobe dysfunction is associated with a pure amnestic syndrome, very slow decline, with atrophy and neurofibrillary tangles limited largely to the medial temporal region including the entorhinal cortex. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-09
Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration
52/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: We found no evidence of acceleration in whole-brain atrophy rates in any group.
Full summary, score breakdown and related studies → Original source
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2013-01-08
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
56/100 ✓ Peer-reviewed Genetics Nature reviews. Neurology
Key finding: APOE polymorphic alleles are the main genetic determinants of Alzheimer disease (AD) risk: individuals carrying the ε4 allele are at increased risk of AD compared with those carrying the more common ε3 allele, whereas the ε2 allele decreases risk. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-07
Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Key finding: Fewer GNs in the anterior DG were present in unmedicated-MDDs compared with controls (p=0.013).
Full summary, score breakdown and related studies → Original source
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2013-01-07
Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis
47/100 ✓ Peer-reviewed Disparities Human molecular genetics
Key finding: We subsequently sequenced CTSF in 22 unrelated individuals with suspected recessive Kufs disease, and identified an additional patient with compound heterozygous mutations. +4 more findings
Full summary, score breakdown and related studies → Original source
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