Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,426–18,450 of 27,380 studies, newest first · page 738 of 1096.
September 2013 24
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2013-09-09
Bridging animal and human models of exercise-induced brain plasticity
36/100 ✓ Peer-reviewed Prevention trials Trends in cognitive sciences
Key finding: Significant progress has been made in understanding the neurobiological mechanisms through which exercise protects and restores the brain. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-09-08
Long-term health benefits of physical activity--a systematic review of longitudinal studies
71/100 ✓ Peer-reviewed How common it is BMC public health
Key finding: This review revealed a paucity of long-term studies on the relationship between physical activity and the incidence of NCD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-07
Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve
36/100 ✓ Peer-reviewed Risk factors Trends in cognitive sciences
Key finding: We conclude that cognitive reserve is compatible and complementary with many related concepts, but that each much draw sharper conceptual boundaries in order to truly explain preserved cognitive function in the face of aging or brain damage.
Full summary, score breakdown and related studies → Original source
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2013-09-05
Increased risk of cognitive impairment in patients with diabetes is associated with metformin
52/100 ✓ Peer-reviewed Drug development Diabetes care
Key finding: Metformin use was associated with impaired cognitive performance. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-05
Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using spectral-domain optical coherence tomography
50/100 ✓ Peer-reviewed Brain scans and imaging Investigative ophthalmology & visual science
Key finding: These results indicate that RNFL and RNFL+GCL thickness measurements are reduced in AD patients compared with healthy subjects. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-05
Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study
57/100 ✓ Peer-reviewed Vascular contributions The Lancet. Neurology
Key finding: We assessed whether expansion size is associated with disease severity or phenotype. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-05
Cognitive, emotional, and social benefits of regular musical activities in early dementia: randomized controlled study
68/100 ✓ Peer-reviewed Caregiving The Gerontologist
Key finding: Purpose of the study During aging, musical activities can help maintain physical and mental health and cognitive abilities, but their rehabilitative use has not been systematically explored in persons with dementia (PWDs).
Full summary, score breakdown and related studies → Original source
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2013-09-04
Targeting the neural extracellular matrix in neurological disorders
36/100 ✓ Peer-reviewed Vascular contributions Neuroscience
Key finding: It is associated with the structural stabilization of neuronal processes and synaptic contacts during the maturation of the central nervous system.
Full summary, score breakdown and related studies → Original source
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2013-09-04
Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease
54/100 ✓ Peer-reviewed Risk genes beyond APOE Annals of neurology
Key finding: Using quantitative polymerase chain reaction techniques, we measured circulating cell-free mitochondrial DNA (mtDNA) in cerebrospinal fluid (CSF) from study participants, selected from a cohort of 282 subjects, who were classified according to their concentrations of amyloid β1-42, total tau, and phosphorylated tau and by the presence or absence of dementia, into asymptomatic subjects at risk of AD, symptomatic patients diagnosed with sporadic AD, presymptomatic subjects carrying pathogenic PSEN1 mutations, and patients diagnosed with frontotemporal lobar degeneration (FTLD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-04
Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study
61/100 ✓ Peer-reviewed How common it is The Lancet. Neurology
Key finding: Compared with individuals classed as normal, participants with preclinical Alzheimer's disease had an increased risk of death after adjusting for covariates (hazard ratio 6·2, 95% CI 1·1-35·0; p=0·040). +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-09-01
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein
36/100 ✓ Peer-reviewed Disease mechanisms Neuron
Key finding: PrP(C) and mGluR5 interact physically, and cytoplasmic Fyn forms a complex with mGluR5. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-01
Cognitive frailty: rational and definition from an (I.A.N.A./I.A.G.G.) international consensus group
40/100 ✓ Peer-reviewed Prevention trials The journal of nutrition, health & aging
Key finding: The present report describes the results of the Consensus Group and provides the first definition of a "Cognitive Frailty" condition in older adults.
Full summary, score breakdown and related studies → Original source
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2013-09-01
Seizures and epileptiform activity in the early stages of Alzheimer disease
47/100 ✓ Peer-reviewed Risk genes beyond APOE JAMA neurology
Key finding: Patients with aMCI who had epilepsy presented with symptoms of cognitive decline 6.8 years earlier than patients with aMCI who did not have epilepsy (64.3 vs 71.1 years; P = .02). +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-09-01
Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction
36/100 ✓ Peer-reviewed Clinical safety The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: This increasing susceptibility is associated with increased CNS expression of cyclooxygenase (COX)-1 in microglia and perivascular macrophages. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-09-01
A cross sectional study to examine the association between dietary patterns and cognitive impairment in older Chinese people in Hong Kong
69/100 ✓ Peer-reviewed Prevention trials The journal of nutrition, health & aging
Key finding: Higher "vegetables-fruits" and "snacks-drinks-milk products" pattern scores were associated with reduced risk of cognitive impairment in Chinese older women in Hong Kong. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-01
Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Seminars in neurology
Key finding: Alzheimer's disease (AD) is the most common neurodegenerative cause of dementia and is responsible for significant individual morbidity and mortality, and economic impact on the health care system.
Full summary, score breakdown and related studies → Original source
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2013-09-01
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls
36/100 ✓ Peer-reviewed Disease mechanisms Neuron
Key finding: In vivo optical and positron emission tomographic (PET) imaging of a transgenic mouse model demonstrated sensitive detection of tau inclusions by PBBs.
Full summary, score breakdown and related studies → Original source
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2013-09-01
Hypercortisolemia and glucocorticoid receptor-signaling insufficiency in Alzheimer's disease initiation and development
50/100 ✓ Peer-reviewed Inflammation and the immune system Current Alzheimer research
Key finding: Theoretical implications are discussed in this review. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-01
CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study
53/100 ✓ Peer-reviewed Inflammation and the immune system Current Alzheimer research
Key finding: There were no clinically significant treatmentrelated clinical laboratory, vital sign or ECG abnormalities. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-01
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease
54/100 ✓ Peer-reviewed TREM2 and immune genetics Neuron
Key finding: Accordingly, impairments in different receptors or proteins involved in phagocytosis result in enhanced inflammation and neurodegeneration. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-01
Structural covariance of the default network in healthy and pathological aging
54/100 ✓ Peer-reviewed Mild cognitive impairment The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Significant progress has been made uncovering functional brain networks, yet little is known about the corresponding structural covariance networks. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-01
Impaired functional connectivity of the thalamus in Alzheimer's disease and mild cognitive impairment: a resting-state fMRI study
47/100 ✓ Peer-reviewed Brain scans and imaging Current Alzheimer research
Key finding: Our results revealed disease severity-related alterations of the thalamo-default mode network and thalamocortical connectivity in AD and MCI patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-01
Cognitive contributions to gait and falls: evidence and implications
54/100 ✓ Peer-reviewed Prevention and risk Movement disorders : official journal of the Movement Disorder Society
Key finding: Several neuropsychological investigations have also demonstrated that walking relies on the use of several cognitive domains, including executive-attentional function, visuospatial abilities, and even memory resources.
Full summary, score breakdown and related studies → Original source
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2013-09-01
Genetic susceptibility for Alzheimer disease neuritic plaque pathology
57/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: These findings enhance understanding of AD risk factors by relating validated susceptibility alleles to increased neuritic plaque pathology and implicate common genetic variation at the APP locus in the earliest, presymptomatic stages of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
August 2013 1
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2013-08-31
Globular glial tauopathies (GGT): consensus recommendations
47/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica
Key finding: These cases are associated with a range of clinical presentations, which correlate with the severity and distribution of underlying tau pathology and neurodegeneration. +1 more finding
Full summary, score breakdown and related studies → Original source
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