Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,676–19,700 of 27,380 studies, newest first · page 788 of 1096.
January 2012 25
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2012-01-30
Family perceptions of end-of-life care for long-term care residents with dementia: differences between the United States and the Netherlands
36/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Because previous research favored care in the Netherlands to that in the United States, findings suggest improvement in end-of-life care and outcomes in the United States and stability in the Netherlands. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-01-30
The disappearing subject: exclusion of people with cognitive impairment and dementia from geriatrics research
50/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society
Key finding: All original research articles published in 2008 and 2009 in the Journal of the American Geriatrics Society (n = 434) were reviewed using a structured data collection tool. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-30
CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease
58/100 ✓ Peer-reviewed Mild cognitive impairment PloS one
Key finding: Only CSF CCL26 was statistically significantly elevated in patients with prodromal AD when compared to controls (p = 0.002). +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-29
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
41/100 ✓ Peer-reviewed Brain scans and imaging Nature medicine
Key finding: In primary neuronal culture, we found loss of tau also causes iron retention, by decreasing surface trafficking of APP. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-28
Using Support Vector Machine to identify imaging biomarkers of neurological and psychiatric disease: a critical review
36/100 ✓ Peer-reviewed Risk factors Neuroscience and biobehavioral reviews
Key finding: Standard univariate analysis of neuroimaging data has revealed a host of neuroanatomical and functional differences between healthy individuals and patients suffering a wide range of neurological and psychiatric disorders. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-27
Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates
36/100 ✓ Peer-reviewed Clinical safety Neurochemistry international
Key finding: Although the cellular mechanisms driving the abnormal accumulation of TDP-43 are not understood, recent studies have shown that an early change to TDP-43 metabolism in disease may be accumulation in cytosolic RNA stress granules (SGs). +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-24
Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines
58/100 ✓ Peer-reviewed Getting a diagnosis Movement disorders : official journal of the Movement Disorder Society
Key finding: These diagnostic criteria will support future research efforts to identify at the earliest stage those PD patients at increased risk of progressive cognitive decline and dementia who may benefit from clinical interventions at a predementia stage.
Full summary, score breakdown and related studies → Original source
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2012-01-21
The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
52/100 ✓ Peer-reviewed Lewy body dementia Brain research
Key finding: Recently, perturbed RNA-binding proteostasis of TAF15, which is the 2nd ranked RRM-bearing prion candidate, has been connected with ALS and FTLD-U. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-18
Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease
48/100 ✓ Peer-reviewed Biomarkers PloS one
Key finding: It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-18
Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study
58/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: Cerebral microbleeds are frequently found in the general elderly population and may reflect underlying vascular disease, but their role in cognitive function is unknown. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-17
Using PET with 18F-AV-45 (florbetapir) to quantify brain amyloid load in a clinical environment
50/100 ✓ Peer-reviewed Brain scans and imaging European Journal of Nuclear Medicine and Molecular Imaging
Key finding: The mean values of SUVr were higher in AD patients (median 1.20, Q1-Q3 1.16-1.30) than in HC subjects (median 1.05, Q1-Q3 1.04-1.08; p = 0.0001) in the overall cortex and all cortical regions (precuneus, anterior and posterior cingulate, and frontal median, temporal, parietal and occipital cortex). +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-16
Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice
40/100 ✓ Peer-reviewed Biomarkers Journal of neuroinflammation
Key finding: We have shown that chronically administered cannabinoid showed marked beneficial effects concomitant with inflammation reduction and increased Aβ clearance. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-16
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
68/100 ✓ Peer-reviewed Genetics Molecular neurodegeneration
Key finding: We identified a new genetic risk association of AD with rare coding CLU variations that is independent of the 5' common association signal identified in the GWA studies. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-13
Using virtual reality to characterize episodic memory profiles in amnestic mild cognitive impairment and Alzheimer's disease: influence of active and passive encoding
43/100 ✓ Peer-reviewed Mild cognitive impairment Neuropsychologia
Key finding: Third, we benchmarked the results of our virtual reality episodic memory test against a classical memory test and a subjective daily memory complaint scale. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-11
Cerebral microinfarcts: a systematic review of neuropathological studies
65/100 ✓ Peer-reviewed Brain scans and imaging Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Key finding: Vascular cognitive impairment is an umbrella term for cognitive dysfunction associated with and presumed to be caused by vascular brain damage. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-01-10
Association between polypharmacy and dementia in older people: a population-based case-control study in Taiwan
41/100 ✓ Peer-reviewed Digital health tools Geriatrics & gerontology international
Key finding: The risk of dementia increases steadily with the number of medications used and age in older people in Taiwan. +3 more findings
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2012-01-10
FreeSurfer
59/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage
Key finding: FreeSurfer provides an array of algorithms to quantify the functional, connectional and structural properties of the human brain. +2 more findings
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2012-01-10
Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries, 1993-2007
66/100 ✓ Peer-reviewed Getting a diagnosis Circulation. Cardiovascular quality and outcomes
Key finding: Among older Medicare beneficiaries, incident AF is common and has remained relatively stable for more than a decade. +2 more findings
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2012-01-06
APOE genotype alters glial activation and loss of synaptic markers in mice
38/100 ✓ Peer-reviewed Genetics Glia
Key finding: APOE4 mice displayed increased glial activation in response to intracerebroventricular lipopolysaccharide (LPS) compared to APOE2 and APOE3 mice by several measures. +3 more findings
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2012-01-06
Cognitive impairment and vitamin B12: a review
36/100 ✓ Peer-reviewed Drug development International psychogeriatrics
Key finding: Low serum vitamin B12 levels are associated with neurodegenerative disease and cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-05
Omega-3 fatty acids EPA and DHA: health benefits throughout life
36/100 ✓ Peer-reviewed Brain scans and imaging Advances in nutrition (Bethesda, Md.)
Key finding: Recently, fish-derived omega-3 fatty acids EPA and DHA have been associated with fetal development, cardiovascular function, and Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-05
Identification and proteomic profiling of exosomes in human cerebrospinal fluid
40/100 ✓ Peer-reviewed Tau biomarkers Journal of translational medicine
Key finding: Exosomes were identified in human CSF and their proteome is a potential new reservoir for biomarker discovery in neurological disorders such as Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2012-01-04
Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span
36/100 ✓ Peer-reviewed Vascular contributions The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: We observed a progressive delay in the age of onset of physical and cognitive function impairment, age-related diseases, and overall morbidity with increasing age.
Full summary, score breakdown and related studies → Original source
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2012-01-04
S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice
41/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging
Key finding: We previously demonstrated that hyperhomocysteinemia and DNA hypomethylation induced by B vitamin deficiency are associated with PSEN1 and BACE1 overexpression and amyloid production. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-01-04
Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice
47/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Recent focus has been directed toward a group of naturally occurring anti-amyloidogenic polyphenols known as flavonoids. +3 more findings
Full summary, score breakdown and related studies → Original source
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