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57/100

✓ Peer-reviewed alzhub usefulness score 57 out of 100. Vascular contributions

Topic: Risk, prevention and care in population studies

People with severe mental illnesses (SMIs), including schizophrenia spectrum disorders (SSD), major depressive disorder (MDD), and bipolar disorder (BD), experience elevated rates of physical comorbidity and premature mortality. Dementia and ischemic stroke contribute substantially to this burden, yet age-specific patterns of these associations remain poorly characterized. To bridge this gap, we conducted a population-based cross-sectional study using the PADRIS-PRESTO cohort, integrating primary and specialized care records from the Catalan public health system (Spain). Adults with a lifetime SMI diagnosis were compared with controls without any psychiatric condition. Weighted age-stratified prevalence was calculated and logistic regression models estimated age-specific odds ratios (ORs) with 95% confidence intervals (CIs), adjusting for socioeconomic status and medical comorbidity burden. Among 694,086 participants, 176,870 had an SMI diagnosis. Dementia prevalence was 3.49% (range, 0.33% at ages 20-29 to 39.51% at 90-99 years) in SMIs and 0.36% (0.02%-17.7%) in controls. Ischemic stroke prevalence was 5.3% (0.22%-16.4%) in SMIs and 2.75% (0.08%-14.67%) in controls. The ORs between SMI and dementia were significant across all age groups, with the strongest association observed at younger ages (OR = 23.21, 95% CIs = 13.74-39.19 at 30-39 years). Elevated ORs for stroke persisted up to 70-79 years, peaking at 40-49 years (OR = 2.99, 95% CIs = 2.63-3.41). Patterns were consistent across SMI subtypes. These findings highlight the need for earlier and more systematic neurological and cardiometabolic screening and management within psychiatric care and support policies that recognize SMIs as risk factors for vascular diseases and dementia.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

De Prisco, M., Oliva, V., Sánchez‐Valle, R., Parellada, E., Junqué, C., Martí, M. J., et al. (2026). Age-stratified associations between severe mental illness, dementia, and ischemic stroke: findings from the PADRIS-PRESTO cohort. European Neuropsychopharmacology. https://doi.org/10.1016/j.euroneuro.2026.112850

Vancouver

De Prisco M, Oliva V, Sánchez‐Valle R, Parellada E, Junqué C, Martí MJ, et al. Age-stratified associations between severe mental illness, dementia, and ischemic stroke: findings from the PADRIS-PRESTO cohort. European Neuropsychopharmacology. 2026. doi:10.1016/j.euroneuro.2026.112850. PMID: 42013686.

BibTeX

@article{deprisco2026-42013686,
  author  = {De Prisco, Michele and Oliva, Vincenzo and Sánchez‐Valle, Raquel and Parellada, Eduard and Junqué, Carme and Martí, M. J. and Bortolozzi, Analı́a A and Alberch, Jordi and others},
  title   = {{Age-stratified associations between severe mental illness, dementia, and ischemic stroke: findings from the PADRIS-PRESTO cohort}},
  journal = {European Neuropsychopharmacology},
  year    = {2026},
  doi     = {10.1016/j.euroneuro.2026.112850},
  pmid    = {42013686},
  url     = {https://doi.org/10.1016/j.euroneuro.2026.112850}
}

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Key findings

Adults with a lifetime SMI diagnosis were compared with controls without any psychiatric condition.
The ORs between SMI and dementia were significant across all age groups, with the strongest association observed at younger ages (OR = 23.21, 95% CIs = 13.74-39.19 at 30-39 years).
These findings highlight the need for earlier and more systematic neurological and cardiometabolic screening and management within psychiatric care and support policies that recognize SMIs as risk factors for vascular diseases and dementia.

Why it matters

In this population, people with a lifetime severe mental illness diagnosis had higher odds of dementia across all age groups, with the strongest link at younger ages. The authors say this points to the need for earlier and more systematic neurological and cardiometabolic screening within psychiatric care.

Study details

Study designcross-sectional
Participants694,086
Effect size3.49%; 0.33%; 39.51%
Evidence strengthModerate

How this study scored 57/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (European Neuropsychopharmacology)
Journal's citation record	2 / 4	European Neuropsychopharmacology: journal h-index 158 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	4 / 4	694,086 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.5 citations a year over 2 year(s) since 2026
Impact for its field and year	4 / 6	Cited 14.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Gerard Anmella: h-index 24 (OpenAlex, whole career)
Institution's track record	1 / 3	Universitat de Barcelona: institution h-index 1,049 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 11 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 42013686)
Free to read	2 / 2	Free to read
Total	57 / 100	—

What each of these 20 components measures, and what this score is not →

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