Newest studies

Associations of modifiable and non-modifiable risk factors with longitudinal white matter hyperintensities, amyloid-β and tau - a prospective cohort study

53/100 ✓ Peer-reviewed Vascular contributions The Journal of Prevention of Alzheimer s Disease

Key finding: Non-modifiable (age, apolipoprotein E (APOE) ɛ4 genotype and sex) and modifiable risk factors (co-morbidities at baseline, such as hypertension and cardiovascular disease, BMI, and sleep duration) were analyzed with mixed-effects models, adjusted for age and sex, to predict longitudinal measurements of WMH, Aβ and tau. +4 more findings

• Risk Factors
• Genetics
• Prevention

Full summary, score breakdown and related studies → Original source

Silent yet impaired: Hidden memory processing deficits in asymptomatic individuals with moderate‐to‐severe white matter hyperintensities

45/100 ✓ Peer-reviewed Vascular contributions Alzheimer s & Dementia

Key finding: Individuals with msWMH showed systematic deficits in face-memory processing across encoding, maintenance, and retrieval, accompanied by reduced theta power and synchronization, altered alpha power, and disrupted theta-gamma coupling. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Glymphatic dysfunction associates with regional white matter hyperintensities and plasma amyloid-β burden across the Alzheimer’s disease continuum

41/100 ✓ Peer-reviewed Vascular contributions Psychological Medicine

Key finding: Plasma Aβ levels and regional WMH burden are associated with glymphatic dysfunction as indicated by reduced ALPS. +2 more findings

• Brain Scans
• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

The association of estimated glucose disposal rate with white matter hyperintensities: A large prospective cohort study

43/100 ✓ Peer-reviewed Vascular contributions The Journal of Prevention of Alzheimer s Disease

Key finding: Each 1-SD increase in eGDR was significantly associated with a reduction in WMH volume (β = -0.057; 95% CI: -0.062 to -0.051; p 0.05). +2 more findings

Full summary, score breakdown and related studies → Original source

Elevated serum inflammasome adaptor protein ASC is associated with white matter hyperintensities in vascular cognitive impairment

47/100 ✓ Peer-reviewed Vascular contributions Brain Communications

Key finding: Compared to controls, serum ASC levels were increased in the VCI clinical subgroups, namely, cognitive impaired, no dementia with CeVD, AD with CeVD and VaD. +3 more findings

• Brain Scans
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

The Inaugural Voyage of the South Asian Journal of Geriatric Medicine, Surgery, Palliative Care, and Hospice

31/100 ✓ Peer-reviewed End-of-life care South Asian Journal of Geriatric Medicine Surgery Palliative Care & Hospice

Key finding: This Journal is not only a new publication but also the culmination of a shared vision and a timely response to one of the most significant demographic shifts in human history: the rapid aging of the South Asian population. +4 more findings

• End-of-Life Care
• Health Equity

Full summary, score breakdown and related studies → Original source

Impact of home healthcare reform on place of death for people with dementia: A nationwide cohort study accounting for cultural factors of impending death discharge

52/100 ✓ Peer-reviewed End-of-life care Palliative & Supportive Care

Key finding: Among 209,468 decedents, 95,594 were selected after matching. +4 more findings

• End-of-Life Care

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Advancing Knowledge Translation Through Cultural Adaptation of an Intervention for Latino Family Caregivers of Persons Living With Dementia Using Participatory Action Research

37/100 ✓ Peer-reviewed End-of-life care International Journal of Nursing Practice

Key finding: Three changes to the intervention content were determined from the different sources of data. +4 more findings

• Caregiving
• Health Equity

Full summary, score breakdown and related studies → Original source

Physical and psychosocial benefits of an interdisciplinary end-of-life care model for older adults in residential care homes in Hong Kong

45/100 ✓ Peer-reviewed End-of-life care International Psychogeriatrics

Key finding: Pre-post evaluations revealed significant reductions in physical symptoms, psychosocial-spiritual distresses and information insufficiency of patients in the first three months of service. +3 more findings

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

A program of SUPPORT-D TM : Feasibility and acceptability of an early palliative care intervention for those living with dementia and caregivers

35/100 ✓ Peer-reviewed End-of-life care Palliative & Supportive Care

Key finding: Seventy-six percent (23/30) of enrolled dyads successfully completed the study. +1 more finding

• End-of-Life Care
• Caregiving

Full summary, score breakdown and related studies → Original source

Advance care planning in Japan: Gaps between policy, ethical understanding, and its translation into clinical practice

41/100 ✓ Peer-reviewed End-of-life care Palliative Care and Social Practice

Key finding: Misconceptions were common: 38% of participants equated ACP exclusively with decisions to forgo active treatment, and many conflated ACP with current rather than future-oriented care planning. +4 more findings

• End-of-Life Care
• Policy

Full summary, score breakdown and related studies → Original source

Behavioral Variant Frontotemporal Dementia With C9orf72 Intermediate Repeat Expansion

33/100 ✓ Peer-reviewed Clinical safety Alzheimer Disease & Associated Disorders

Key finding: Here, we report a rare case of behavioral variant frontotemporal dementia (bvFTD) associated with a C9orf72 repeat expansion of 49 units, a size that falls within the intermediate-length range. +1 more finding

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Assessment of heart rate variability and occurrence of falls in Alzheimer's disease: an exploratory study

35/100 ✓ Peer-reviewed Clinical safety Arquivos de Neuro-Psiquiatria

Key finding: The AD group presented more falls, whose incidence was associated with HRV components.

Full summary, score breakdown and related studies → Original source

Depression and risk of cognitive decline and dementia: Implications and strategies for prevention

43/100 ✓ Peer-reviewed Prevention trials Journal of Geriatric Mental Health

Key finding: Dementia, a syndrome characterized by a decline in cognitive function beyond what is expected from normal aging, poses a significant global health challenge. +4 more findings

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

31/100 ✓ Peer-reviewed Prevention trials Chalmers Research (Chalmers University of Technology)

Key finding: The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all-cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers. +1 more finding

• Lifestyle
• Prevention

Full summary, score breakdown and related studies → Original source

Impact of cognitive training on claims‐based diagnosed dementia over 20 years: evidence from the ACTIVE study

72/100 ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: Cognitive training involving speed of cognitive processing has the potential to delay the diagnosis of ADRD.

• Clinical Trials
• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Microglia-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Carry miRNAs Driving a Neuroinflammatory Response

43/100 ✓ Peer-reviewed Inflammation and the immune system Molecular Neurobiology

Key finding: Using a HEK TLR reporter cell system, we found that these miRNA are potent activators of human TLR8, an established RNA sensor. +1 more finding

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Neuroinflammation demonstrated by 11 C‐ER176 PET with amyloid and tau pathology

39/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer s & Dementia

Key finding: These findings suggest probable amyloid association with early microglial activation, while tau pathology is closely tied to wider distribution of neuroinflammation. +2 more findings

• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Inhibiting Glycogen Synthase Kinase 3 Suppresses TDP-43-Mediated Neurotoxicity in a Caspase-Dependent Manner

42/100 ✓ Peer-reviewed Brain tissue and pathology Molecular Neurobiology

Key finding: We show that TDP-43 activates GSK3 and promotes caspase-dependent cleavage of TDP-43, generating C-terminal fragments. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Small molecule JRMS modulating importin-β1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology

38/100 ✓ Peer-reviewed Brain tissue and pathology Neurotherapeutics

Key finding: Previous studies have demonstrated that increased expression of KPNB1 solubilizes TDP-43 aggregates and restores its nuclear localization. +1 more finding

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Prediabetes as a critical stage for risk of dementia and stroke: evidence from the UK Biobank and Mendelian randomization.:evidence from the UK Biobank and Mendelian Randomization

48/100 ✓ Peer-reviewed Long-term cohort studies Pure Amsterdam UMC

Key finding: During a median 13.7 years of follow-up, prediabetes (n=52,693) was associated with higher risks of vascular dementia (hazard ratio (HR):1.36; 95% confidence interval (CI): 1.14-1.61), stroke (HR:1.09; 95% CI: 1.01-1.16), ischemic stroke (HR:1.10; 95% CI: 1.02-1.19), and intracerebral hemorrhage (HR:1.19; 95% CI: 1.01-1.39) compared with normoglycemia, after adjustment for major confounding factors and across extensive sensitivity analyses. +4 more findings

• Brain Scans
• Risk Factors

Full summary, score breakdown and related studies → Original source

Delirium and adverse clinical outcomes: a matched cohort study in the UK Biobank

62/100 ✓ Peer-reviewed Long-term cohort studies The Lancet Healthy Longevity

Key finding: Over a maximum follow-up of 26 years, the median time to event was 1·2 years (IQR 0·2-3·3) in the delirium group and 1·3 years (0·3-3·6) in the control group. +4 more findings

Full summary, score breakdown and related studies → Original source

Peripheral biomarkers associated with apathy and predicting response to methylphenidate: Secondary analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET2) study

51/100 ✓ Peer-reviewed Cognitive tests and assessment International Psychogeriatrics

Key finding: In the ADMET2 biomarker subset (n = 44, MPH:21, age:75 years, MMSE:20.2), higher baseline TNF was associated with higher M6 NPI-A [B(SE)= 6.86 (1.71), p = .0003], and multivariable models found lower baseline TNF [B(SE)= 8.28(1.61), p < .001] and higher baseline S100B [B(SE)= -6.41(1.95), p = .002] were associated with lower M6 NPI-A. +4 more findings

• Biomarkers
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Comparative methods for determining MoCA, MMSE, and CDR cut‐offs in Alzheimer's disease: insights from the ADNI study

35/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: For MCI, MoCA cut-offs were 24 (three methods) and 25 (Youden's J Index). +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Identification and functional verification of new molecular targets of blood – cerebrospinal fluid and exosomes from patients with neurodegenerative diseases

29/100 ✓ Peer-reviewed Tau biomarkers Aristotle University of Thessaloniki

Key finding: Η νευρωνική εκφύλιση και δυσλειτουργία αποτελούν χαρακτηριστικά γνωρίσματα των νευροεκφυλιστικών ασθενειών. Σημαντική πρόκληση είναι η ανάπτυξη αξιόπιστων διαγνωστικών εργαλείων που θα επιτρέπουν την έγκαιρη διάγνωση των νόσων αυτών. Πρώτος στόχος της παρούσας διδακτορικής διατριβής είναι ο ποσοτικό +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source