Newest studies

Glucagon-Like Peptide-1 Receptor Agonists Inhibit the Initiation of Toxic Amyloid-β42 Aggregation

45/100 ✓ Peer-reviewed Drug development Journal of the American Chemical Society

Key finding: Liraglutide was highly effective at suppressing primary nucleation with a very low KIP value, and it demonstrated an additional modest inhibition of secondary nucleation. +2 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

County-Level Ecological Association Between Glyphosate Exposure and Chronic Disease Mortality in Midwestern US Agricultural Communities

28/100 ✓ Peer-reviewed Risk factors Cureus

Key finding: Concerns have been raised regarding potential long-term health effects associated with environmental exposure. +2 more findings

Full summary, score breakdown and related studies → Original source

Overcoming the blood–brain barrier in Alzheimer's disease: translational perspectives on advanced drug delivery platforms

38/100 ✓ Peer-reviewed Disease mechanisms Frontiers in Neuroscience

Key finding: These properties can improve drug solubility, stability, pharmacokinetics, and targeted brain accumulation while reducing systemic toxicity. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

TDP-43: [GU]-ardian of the transcriptome

42/100 ✓ Peer-reviewed Brain tissue and pathology Molecular Neurodegeneration

Key finding: TDP-43 nuclear depletion and cytoplasmic aggregation are well-established pathological features in affected neurons and glia of neurodegenerative diseases, and accumulating evidence suggests that loss of TDP-43-mediated splicing repression occurs presymptomatically in disease.

• Brain Biology

Full summary, score breakdown and related studies → Original source

The bidirectional association of epilepsy with Alzheimer's disease and other neurodegenerative dementias: A longitudinal observational study on the UK Biobank

33/100 ✓ Peer-reviewed Long-term cohort studies Journal of Alzheimer s Disease

Key finding: Our findings reinforce the notion of a bidirectional association between epilepsy and AD, providing proof-of-concept that epilepsy, especially late-onset, may be successfully integrated into AD risk frameworks. +4 more findings

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

predALZ: An Ensemble Learning Framework for Identifying Genetic Biomarkers in Familial Alzheimer’s Disease

29/100 ✓ Peer-reviewed Genetics Current Drug Targets

Key finding: The predALZ framework achieved 94% accuracy on an independent test set and approximately 96% accuracy in cross-validation for Alzheimer-related driver gene prediction. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Glial Fibrillary Acidic Protein and Neurofilament Light Reference Intervals in Healthy Individuals

55/100 ✓ Peer-reviewed Biomarkers JAMA Network Open

Key finding: In 7989 cognitively unimpaired participants (median [range] age, 54 [30-90] years; 4877 [61.3%] female; mean [SD] BMI, 25.9 [4.2]; mean [SD] eGFR, 80.7 [14.7] mL/min/1.73 m2), older age, lower BMI, and reduced kidney function were associated with increased NfL and GFAP concentrations; female sex was associated with increased GFAP concentrations. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Biopsychosocial risk factors for Alzheimer’s disease and related dementias in UK immigrants from the Middle East and North Africa (MENA)

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: MENA immigrants exhibited a distinct and adverse risk profile characterized by greater socioeconomic deprivation, higher exposure to air pollution, poorer diet quality, lower physical activity, worse sleep, and higher smoking prevalence compared to European immigrant groups. +3 more findings

• Risk Factors
• Lifestyle

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

MIND diet moderates the associations between cerebrovascular and neurodegenerative disease burden and cognition

38/100 ✓ Peer-reviewed Prevention trials Frontiers in Nutrition

Key finding: The MIND diet may buffer the cognitive consequences of cerebrovascular pathology and cortical atrophy in older adults at elevated dementia risk and promote cognitive resilience over general healthy eating guidelines. +1 more finding

• Lifestyle
• Brain Scans

Full summary, score breakdown and related studies → Original source

Extracellular Vesicles in Alzheimer’s Disease: Mechanisms, Immunotherapy Links, and Clinical Translation

33/100 ✓ Peer-reviewed Disease mechanisms Current Pharmaceutical Design

Key finding: Nevertheless, emerging data show that lipid metabolism is an important and well-established aspect of AD pathophysiology rather than a new theory. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Clinical Meaningfulness of Donanemab in Early Symptomatic Alzheimer Disease: Data From the Randomized Phase 3 TRAILBLAZER-ALZ 2 Trial

63/100 ✓ Peer-reviewed Clinical trials Neurology: Clinical Practice

Key finding: Donanemab, a monoclonal antibody targeting the insoluble form of β-amyloid found in plaques, significantly slows cognitive and functional decline of AD in participants with mild cognitive impairment (MCI) or mild AD-related dementia. +3 more findings

• Clinical Trials
• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source

ALZHEIMER PRECOCE: FATORES PREDISPONENTES, DIAGNÓSTICO E MANEJO

26/100 ✓ Peer-reviewed Risk genes beyond APOE Revista Ibero-Americana de Humanidades, Ciências e Educação

Key finding: Esse artigo buscou abordar a Doença de Alzheimer de Início Precoce (DAIP) acerca do curso clínico, dos fatores predisponentes e do manejo, por meio de uma revisão de literatura, com ênfase na diferenciação entre DAIP e Doença de Alzheimer de Início Tardio (DAIT), incluindo artigos publicados entre 2015 e 2025, obtidos nas bases de dados “Alzheimer's Association”, “ScienceDirect”, “Cochrane” e “PubMed”, utilizando as palavras-chave “Alzheimer”, “early” e “on-set”, com o conectivo AND. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Plasma Phosphorylated Tau217–A Pivotal Plasma Biomarker for Predicting the Progression of Mild Cognitive Impairment to Alzheimer’s Disease: A Reanalysis of ADNI Data

53/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Clinical and Experimental Neuropsychology

Key finding: P-tau217 demonstrated the most significant inter-group differences, the highest hazard ratio, and best distinguished MCI-Converters from MCI-Nonconverters, with its discriminative performance comparable to that of Aβ-PET measures and multi-plasma biomarker models. +4 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Biomarkører for Alzheimers sykdom – et fremskritt for hvem?

30/100 ✓ Peer-reviewed Biomarkers Tidsskrift for Den norske legeforening

Key finding: 12.05.2026: Debatt - En enkel blodprøve kan nå påvise fosforylert tau-protein 217 (p-tau217) – et biologisk tegn på Alzheimers sykdom, som kan være til stede mange år før de første symptomene viser seg.

Full summary, score breakdown and related studies → Original source

Alzheimer's disease and related dementias (ADRD) after COVID‐19 infection: trends and disparities

39/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia Behavior & Socioeconomics of Aging

Key finding: COVID‐19 increases new MCI/ADRD risk. +1 more finding

• Health Equity

Full summary, score breakdown and related studies → Original source

Hearing aid effectiveness and probable dementia risk across 33 countries: A pooled analysis of seven cohorts

61/100 ✓ Peer-reviewed Prevention and risk Cell Reports Medicine

Key finding: Given the inconsistent evidence regarding hearing aid use and reduced dementia risk, this study evaluates whether hearing aid use, particularly effective use, is associated with lower probable dementia risk among hearing-impaired older adults. +1 more finding

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Alzheimer's Disease Co-Pathology and Cognitive Impairment in Amyotrophic Lateral Sclerosis

57/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology

Key finding: Compared with healthy controls, patients with ALS - particularly those with cognitive impairment (ALSci) or ALS-FTD - showed elevated AD-related biomarkers. +4 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Fluid Biomarkers of Cognitive Impairments Following Traumatic Brain Injury: A Systematic Review and Meta Analysis

53/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences

Key finding: Among these, neurofilament light chain (NfL), ubiquitin C-terminal hydrolase L1, total tau, and glial fibrillary acidic protein (GFAP) were consistently associated with CI and brain atrophy across various TBI severities and stages. +2 more findings

• Biomarkers
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

A longitudinal analysis of T1-weighted MRI features associated with progression from mild cognitive impairment to Alzheimer’s disease

48/100 ✓ Peer-reviewed Mild cognitive impairment BMC Medical Imaging

Key finding: We identified 8 brain structural features from 192 MRI features that were associated with the risk of MCI progressing to AD, including: left hippocampus, left inferior lateral ventricle, left amygdala, right middle temporal gyrus, left fusiform gyrus, right amygdala, left cortical total volume, and brain parenchyma total volume. +3 more findings

• Early Stage
• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

A deep hybrid CNN-BiLSTM-BiGRU architecture with explainability for mild cognitive impairment detection using EEG

35/100 ✓ Peer-reviewed Mild cognitive impairment Brain Informatics

Key finding: These results demonstrate robust, interpretable EEG-based MCI detection with potential clinical utility.

• Early Stage

Full summary, score breakdown and related studies → Original source

Incidence and Prevalence of Dementia With Lewy Bodies

61/100 ✓ Peer-reviewed How common it is JAMA Neurology

Key finding: From 2520 records screened, 16 population-based studies were included and 12 contributed to meta-analyses. +4 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Perspectives in dementia risk reduction – food for thought

33/100 ✓ Peer-reviewed Prevention and risk Neurodegenerative Disease Management

Key finding: Although the benefits of single-agent nutrient supplementation are unclear, the LipiDiDiet trial has indicated that multinutrient supplementation with Fortasyn Connect may have the potential to improve cognitive function and decrease disease progression in individuals with prodromal Alzheimer's disease. +1 more finding

• Prevention
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Non-economic social deprivation and cognitive functioning later in life: Results from the DELCODE study

48/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

Key finding: Our findings suggest that non-economic social deprivation, especially in terms of access to a grocery store, pharmacy, postal office, and bus stop, might be relevant for maintaining cognitive functioning in old age. +3 more findings

• Risk Factors
• Policy

Full summary, score breakdown and related studies → Original source

The social value of lecanemab for patients with early Alzheimer's disease in Japan

37/100 ✓ Peer-reviewed Costs and economics Journal of Alzheimer's Disease

Key finding: In AD, where the progression of the illness spans a long period and had a significant impact on families and society, narrowly defined value assessments were not sufficient, indicating the need to consider broader social value.

• Treatments
• Policy

Full summary, score breakdown and related studies → Original source

Physical activity, falls, and dementia risk in adults aged ≥ 60: evidence from three cohorts

46/100 ✓ Peer-reviewed Clinical safety International Journal of Behavioral Nutrition and Physical Activity

Key finding: Over a median follow-up of 5.9-7.9 years, 3,492 dementia cases were identified. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source