Newest studies

The Dementia Trials Accelerator (DTA): a UK dementia trials-ready cohort

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv (preprint)

Key finding: Participants aged 65-75 years are approached via existing cohorts and registries. +4 more findings

• Diagnosis

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Impaired cerebrovascular-cerebrospinal fluid coupling is associated with non-motor features of Lewy body disease

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv (preprint)

Key finding: Parkinsons disease and dementia with Lewy bodies patients both demonstrated weaker global BOLD-CSF coupling compared to controls, with no detectable difference between patient groups. +3 more findings

• Other Dementias
• Biomarkers

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Alzheimers disease blood biomarkers reveal proteomic modules of disease progression

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: From these we built continuous progression-focused functional modules that were consistently preserved across 12 independent cohorts comprising 11,042 participants from the Global Neurodegeneration Proteomics Consortium and that associated with cognitive decline, diagnosis and AD-relevant biology.

• Biomarkers

Scored 28 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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MAPT splicing modulators reduce 4R tau and rescue tauopathy phenotypes in human neurons and in a mouse model

40/100 ✓ Peer-reviewed Disease mechanisms Science Translational Medicine

Key finding: These disorders, like frontotemporal dementia (FTD-tau), currently lack effective therapies and can occur sporadically or be inherited when associated with MAPT gene mutations. +2 more findings

• Brain Biology

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Anti-amyloid treatment in Alzheimer disease: updated implications for patients with cerebral amyloid angiopathy and other cerebrovascular conditions

33/100 ✓ Peer-reviewed Treatments Frontiers in Neurology

Key finding: Amyloid-related imaging abnormalities, particularly vasogenic edema and microhemorrhages, constitute a central safety concern and may clinically mimic acute ischemic stroke, complicating emergency decision-making and increasing the risk of inappropriate intravenous thrombolysis (IVT). +4 more findings

• Treatments

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Exploring the Molecular and Biochemical Mechanisms of Aromasin in Modulating COX-2/iNOS for Alzheimer’s Disease-Associated Synaptic Dysfunction: An In Silico Drug Repurposing Study

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: MD simulations demonstrated stable protein-ligand complexes, with average RMSD values of ~ 0.09 nm (COX-2) and ~ 0.65 nm (iNOS), supported by RMSF, SASA, hydrogen-bonding, and radius of gyration analyses. +2 more findings

• Treatments
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Long-term antidepressant use and outcomes in adults: A systematic review

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging PsyArXiv

Key finding: Forty-eight studies, mostly of weak- or moderate-quality, met inclusion criteria. +4 more findings

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Plasma Biomarker Profiles in a Colombian Cohort of Heterozygous APOE3-Christchurch Carriers

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

Key finding: APOE3 Ch -associated resilience is measurably reflected in plasma biomarker trajectories, indicating attenuation of both neuroinflammatory and neurodegenerative processes. +2 more findings

• Biomarkers

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Clinically Relevant Biomarkers of Alzheimer's Disease Are Associated with Age and Cortical Atrophy in Chimpanzees ( Pan troglodytes )

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers bioRxiv

Key finding: We found linear and quadratic relationships between age and several biomarkers and ratios. +4 more findings

• Biomarkers
• Brain Biology

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Entorhinal cortex astrocytes in early Alzheimer disease: Human evidence, cross-species circuit rationale, and translational boundaries

28/100 ✓ Peer-reviewed Genetics Journal of Neuropathology & Experimental Neurology

Key finding: Human data support early EC vulnerability and region- and stage-dependent astrocyte remodeling, whereas the most direct functional evidence comes from rodent medial EC layer II and should be interpreted as circuit plausibility rather than anatomical equivalence to the human EC. +4 more findings

• Brain Biology

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Per-Capita Food Availability and Global Dementia Burden Across Multiple Exposure Windows

35/100 ✓ Peer-reviewed Risk factors Nutrients

Key finding: Higher per-capita food availability was positively associated with dementia outcomes in minimally adjusted models, particularly for the 2005 exposure window, although these associations were substantially attenuated after full covariate adjustment. +3 more findings

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Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations

37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of intellectual disability research : JIDR

Key finding: Frailty in DS is associated with both ID severity and acquired cognitive decline. +4 more findings

• Down Syndrome
• Biomarkers

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Neuroimaging of affective symptoms in Lewy body dementia: A systematic review

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety Research Square

Key finding: Other studies highlighted changes within cortico-striato-limbic pathways typically associated with psychiatric disorders. +1 more finding

• Other Dementias
• Brain Scans

Scored 55 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Myelin maturation failure and oligodendrocyte precursor loss underlie default mode network disruption in a humanized APP knock-in model of Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Treatments bioRxiv

Key finding: In humans, default mode network (DMN) connectivity follows a biphasic trajectory, with a transition from hypersynchrony to hyposynchrony associated with increasing amyloid burden and cognitive decline. +1 more finding

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Multimodal Retinal Imaging for the Detection of Early Alzheimer’s Disease: Combining Biochemical, Structural, and Vascular Biomarkers

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Preprints.org

Key finding: HSI showed significantly lower GLCM correlation at 466 nm in Aβ+ participants, most pronounced in the inferior macula (p = 0.01, AUC = 0.72), and GC-IPL thickness confirmed an “inferior vulnerability zone.” +1 more finding

• Brain Scans
• Biomarkers
• Early Stage

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Amyloid-Tau PET Fusion Reveals Covarying Network Territories Linked to Disease Stage, Cognition, and APOE4 in Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

Key finding: Ninety-six non-artifactual Amyloid-Tau components were identified, of which 73 showed appreciable spatial correspondence between their paired Amyloid and Tau maps, while 17 were Tau-localized and 6 Amyloid-localized. +1 more finding

• Brain Scans

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Interconnected Challenges in Dementia Caregiving: A Co-occurrence Network Analysis of Burden, Unmet Needs, and System Failures Among Caregivers

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving medRxiv (preprint)

Key finding: Co-occurrence networks showed dense within-domain clustering (density 0.61-0.65) and 84 significant cross-domain connections, with the strongest links between behavioral/safety burden and safety-management needs (21.7% of posts) and between emotional burden and emotional-support needs (20.9%).

• Caregiving

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Plasma inflammatory biomarker associations with Alzheimers disease clinical stage and CSF biomarkers: evaluation of sex effects

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: The aim of this study was to determine whether sex modifies peripheral inflammatory biomarker relationships associated with AD pathology and clinical stage. +3 more findings

• Biomarkers
• Brain Biology

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Fine-mapping reveals four TMEM106B haplotypes associated with neurodegenerative risk and preserved cognition at extreme age

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: Genetic variation at the TMEM106B locus has been associated with Alzheimers disease (AD) and related neurodegenerative phenotypes, yet its haplotypic architecture remains incompletely resolved. +1 more finding

• Genetics

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Genomics link obesity and type 2 diabetes to Alzheimers disease to unveil novel biological insights

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv (preprint)

Key finding: These findings elucidate shared cardiometabolic correlates with AD, prioritizes biological pathways, and reveal computationally-nominated drug candidates for preclinical testing.

• Risk Factors
• Genetics

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Long-read sequencing reveals hidden structural complexity within Alzheimers disease-associated GWAS loci

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: At the SHARPIN/PLEC locus, long-read fine-mapping resolved an independent regulatory PLEC haplotype carrying a CpG-rich tandem repeat associated with enhancer methylation and reduced microglial expression. +2 more findings

• Genetics

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Research Trends of Drama Therapy in Mental Health : A Comprehensive Bibliometric analysis

16/100 ⚠ Preprint — not yet peer-reviewed Disparities Research Square

Key finding: Drama therapy is in an accelerated growth phase, with substantial scholarly expansion expected over the next two decades. +3 more findings

• Health Equity
• Treatments

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Efficacy of Curcumin in Neurodegenerative Diseases: From Pharmacokinetic Barriers to Advanced Delivery Systems

72/100 ✓ Peer-reviewed Clinical trials Pharmaceuticals (Basel, Switzerland)

Key finding: Curcumin exhibits neuroprotective activity in preclinical models of the four NDs analysed, acting on six interconnected mechanisms and the gut-brain axis. +4 more findings

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Taulipro rescues mitochondrial dysfunction and inhibits cGAS–STING neuroinflammation in Aβ-driven Alzheimer's disease models

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: In 5×FAD mice, Taulipro reduced Aβ plaque burden across the DG, CA3, cortex, and thalamus, suppressed cGAS-STING-TBK1-IRF3 signaling, and attenuated downstream p-NFκB, TNFα, and IL-18, with superior efficacy compared with Li₂CO₃ or taurine monotherapy. +1 more finding

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Cross-Sectional and Longitudinal Diagnostic Performance of Plasma p-tau217 and p-tau217/Aβ42 in Alzheimer's Disease

71/100 ✓ Peer-reviewed Biomarkers Annals of neurology

Key finding: Combining plasma p-tau with Aβ42 or the Aβ42/40 ratio reduced the intermediate zone. +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source