Newest studies

Mapping social health and dementia risk: A register-based study of older adults in Finland

47/100 ✓ Peer-reviewed Risk factors Social Science & Medicine

Key finding: These findings underscore the importance of accounting for social health and socio-demographic composition in spatial analysis of dementia and demonstrate the value of integrating matching-based and spatial methods to distinguish compositional from contextual disparities in ageing societies.

• Risk Factors

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The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial

73/100 ✓ Peer-reviewed Laboratory science Nature Medicine

Key finding: AL002 demonstrated sustained target engagement and pharmacodynamic responses in the central nervous system, as demonstrated by reductions in soluble TREM2 and increases in osteopontin in cerebrospinal fluid, respectively. +1 more finding

• Clinical Trials
• Side Effects
• Genetics

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Air pollution exposure in Generation Scotland: molecular fingerprints and health outcomes

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: Ambient air pollution has been associated with increased incidence of chronic disease and is estimated to contribute towards 4.2 million early deaths annually. +1 more finding

• Risk Factors

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Genetic risk loci for Parkinson's disease and dementia in a large-scale population-based Taiwanese cohort (TPMI)

64/100 ✓ Peer-reviewed Genetics The Lancet regional health. Western Pacific

Key finding: Among 463,447 TPMI participants, 4381 PD patients and 43,810 controls were analysed. +4 more findings

• Genetics

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Comparison of three plasma p-tau217 assays to detect PET-confirmed Alzheimer's pathologies

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: All assays distinguished amyloid-positive from -negative individuals with high accuracy (89%-95%). +4 more findings

• Biomarkers

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What are the best practices for providing end-of-life care to patients with coexisting COPD, dementia, and cancer?

41/100 ✓ Peer-reviewed End-of-life care Zenodo (CERN European Organization for Nuclear Research)

Key finding: Variability in practice and systemic challenges remain significant barriers to optimal care.

• End-of-Life Care

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What are the best practices for providing end-of-life care to patients with coexisting COPD, dementia, and cancer?

28/100 ✓ Peer-reviewed End-of-life care Zenodo (CERN European Organization for Nuclear Research)

Key finding: Variability in practice and systemic challenges remain significant barriers to optimal care.

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

The Prevalence of Infection and Sepsis Associated Dysphagia in Hospitalised Patients: A Retrospective Cross-sectional Study

46/100 ✓ Peer-reviewed Clinical safety Dysphagia

Key finding: In this study, we aimed to assess the prevalence and factors associated with dysphagia in patients admitted to hospital with infections or sepsis. +2 more findings

• Care Services

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Baseline predictors of neurophysiological response to combined physical and cognitive training in older adults with subjective cognitive decline

53/100 ✓ Peer-reviewed Prevention trials BMC Geriatrics

Key finding: Regression analysis indicated that APOE ε4 non-carriers showed significantly greater improvement in MMN amplitude (β = ‒0.449, p = 0.027). +2 more findings

• Clinical Trials
• Lifestyle

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Transcriptomic signature of frontotemporal lobar degeneration with TDP-43 type C pathology

45/100 ✓ Peer-reviewed Brain tissue and pathology Brain

Key finding: Our findings were compared to other published RNA sequencing data of tauopathies (Alzheimer's dementia, progressive supranuclear palsy and FTLD with MAPT), FTLD-TDP (subtypes A&B) and available proteomics of this cohort. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Cost-effectiveness of a music therapy intervention for people living with dementia: a model for a UK-based economic evaluation

38/100 ✓ Peer-reviewed Cognitive tests and assessment Aging & Mental Health

Key finding: Over a three-month period, MT+CST was more effective than CST alone in improving cognitive function but was not cost-effective due to higher initial costs, including setup and equipment. +3 more findings

• Policy

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Mental health of caregivers for people with dementia and cerebral palsy as a key determinant of caregiver burden: a multivariable analysis

40/100 ✓ Peer-reviewed Caregiving Frontiers in Public Health

Key finding: = 0.049, respectively), followed by musculoskeletal pain in the back and lower limbs. +4 more findings

• Caregiving

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Nocturnal Physiological Associations with Agitation Occurrence and Severity in Dementia: An Explanatory Study Using Contactless Sleep Sensing

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery medRxiv

Key finding: Passive sleep monitoring identified physiologically interpretable sleep markers associated with next-day agitation occurrence, supporting prospective evaluation of under-mattress sensing as a source of short-term risk information for dementia care. +3 more findings

• Lifestyle

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Linking Modifiable Risk Factors to Vascular and Neurodegenerative Brain Changes

48/100 ✓ Peer-reviewed Risk factors GeroScience

Key finding: Findingss: upport multidomain prevention strategies targeting clustered modifiable risks.

• Risk Factors
• Prevention

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Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity

45/100 ✓ Peer-reviewed TREM2 and immune genetics Proceedings of the National Academy of Sciences of the United States of America

Key finding: Together, these findings support emerging evidence from in vivo studies that macrophages and microglia can influence amyloid seeding and introduce a human-relevant in vitro platform to explore how Aβ aggregation intersects with innate immune function and genetic risk. +1 more finding

• Genetics
• Brain Biology

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Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification

45/100 ✓ Peer-reviewed Biomarkers Proceedings of the National Academy of Sciences of the United States of America

Key finding: Our results demonstrate a strong correlation between BD-pTau217 and total pTau217 (ρ = 0.89 to 0.90), with BD-pTau217 showing significantly reduced interference from kidney dysfunction, as evidenced by weaker associations with blood levels of urea (ρBD-pTau217 = 0.02 to 0.06, ρTotal-pTau217 = 0.06 to 0.12) and creatinine (ρBD-pTau217 = 0.03 to 0.08, ρTotal-pTau217 = 0.16 to 0.18). +2 more findings

• Biomarkers
• Diagnosis
• Brain Biology

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The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study

47/100 ✓ Peer-reviewed Clinical safety PLoS Medicine

Key finding: A case-control GWAS was performed in the UK Biobank to identify genetic variants associated with postoperative delirium, adjusted for age, sex, genetic chip, and the first 10 principal components. +4 more findings

• Genetics

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Cognitive training in neurological disorders: meta-analytic evidence for behavioral gains and neural correlates

51/100 ✓ Peer-reviewed Prevention trials Behavioral and Brain Functions

Key finding: Cognitive training produced a significant, moderate improvement in cognitive task performance (Hedges’ g = 0.451, 95% CI 0.207–0.696; p < .001). +4 more findings

• Lifestyle

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MC1 detects tau pathology in chronic traumatic encephalopathy

34/100 ✓ Peer-reviewed Drug development Journal of Neuropathology & Experimental Neurology

Key finding: This epitope reflects an abnormal folding of tau that occurs among the earliest structural alterations in AD, preceding PHF formation.2 In a recent letter to this journal from Sorrentino and colleagues, it was proposed that immunohistochemistry (IHC) with MC1 could be used to distinguish the tau pathology of AD from that of chronic traumatic encephalopathy (CTE).3 CTE is a tauopathy that is uniquely associated with exposure to repeated head injury and therefore likely involves mechanisms of tau accumulation distinct from those of AD.4 Cryo-EM has revealed that the ultrastructural conformation of tau PHFs differs between AD and CTE,5 and this may represent a point of difference for diagnostic purposes.

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Machine Learning-Based Sleep Electroencephalographic Brain Age Index and Dementia Risk: An Individual Participant Data Meta-Analysis

71/100 ✓ Peer-reviewed Biomarkers JAMA network open

Key finding: Across the cohorts, each 10-year increase in BAI was associated with a 39% higher risk of incident dementia (hazard ratio [HR], 1.39 [95% CI, 1.21-1.59]; P Conclusions and relevance In this IPD meta-analysis, a higher sleep EEG-based BAI was associated with a higher risk of incident dementia. +2 more findings

• Risk Factors
• Lifestyle
• Digital Tools

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Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women

69/100 ✓ Peer-reviewed Biomarkers JAMA Network Open

Key finding: Among 2766 participants (mean [SD] age, 69.9 [3.8] years; 486 [17.9%] Black, 196 [7.1%] Hispanic, and 2007 [73.9%] White), 1311 developed the combined end point of MCI or dementia (849 participants with MCI and 752 participants with dementia). +4 more findings

• Early Stage

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Alpha-synuclein co-pathology in a real-world early Alzheimer's disease cohort

77/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Of 65 participants with biomarker-confirmed AD, 21 (32.3%) were αS-SAA positive. +3 more findings

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Multivariate patterns of plasma biomarkers predict region-specific Alzheimer's pathology and cognitive decline across independent cohorts

52/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Specific plasma biomarker combinations predicted amyloid burden in the precuneus, tau in the entorhinal cortex, hippocampal atrophy, and memory decline. +2 more findings

• Biomarkers

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Implementing plasma p-tau217 and cognitive testing for Alzheimer's screening in low-education populations in central China

68/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: MES-defined cognitive impairment (≤-2 standard deviation [SD] deviation after adjustment for demographics) was identified in 12.4% of participants. +4 more findings

• Biomarkers
• Diagnosis

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Genetic architecture of plasma pTau217 and related biomarkers in Alzheimer's disease via genome-wide association studies

63/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Genome-wide significant loci were identified for all biomarkers, including DACT1-DAAM1 (pTau217), KCNJ3 (pTau181), KLHDC4 (NfL), SLC10A7 (GFAP), and PPP4R2 (composite score). +3 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source