Newest studies

Autophagosome-targeting single-domain antibody clears tau in patient-derived neurons and improves motor function in tauopathy mice

36/100 ✓ Peer-reviewed Disease mechanisms Science Translational Medicine

Key finding: These findings underscore the therapeutic potential of sdAb-based protein degraders for tauopathies.

• Brain Biology

Full summary, score breakdown and related studies → Original source

An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration

63/100 ✓ Peer-reviewed Brain tissue and pathology Nature Medicine

Key finding: In a sporadic cohort (n = 513), AcTau174 concentrations were higher in all dementia groups (FTLD-TDP, FTLD-Tau, Alzheimer's disease (AD), mild cognitive impairment (MCI)-AD and dementia with Lewy bodies (DLB)) compared to controls. +2 more findings

• Biomarkers
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Ginkgo biloba and longitudinal changes in amyloid PET and plasma amyloid-β oligomerization in amyloid-positive mild cognitive impairment: A retrospective analysis

48/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer s Disease

Key finding: In amyloid PET–positive MCI, Ginkgo biloba use was associated with sustained clinical stability, reduced plasma Aβ oligomerization tendency, and attenuation of amyloid PET progression over 18 months. +1 more finding

• Early Stage
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Asundexian for Secondary Stroke Prevention

68/100 ✓ Peer-reviewed Prevention and risk New England Journal of Medicine

Key finding: Among 12,327 patients who underwent randomization (6162 to the asundexian group and 6165 to the placebo group), the incidence of ischemic stroke was lower in the asundexian group than in the placebo group (6.2% vs. 8.4%; cause-specific hazard ratio, 0.74; 95% confidence interval [CI], 0.65 to 0.84; P<0.001). +4 more findings

• Clinical Trials
• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Cross-Platform Concordance of Quantitative Amyloid PET Z-Scores in a Real-World Clinical Cohort of Patients with Cognitive Impairment and Suspected Alzheimer Disease

34/100 ✓ Peer-reviewed Biomarkers American Journal of Neuroradiology

Key finding: Agreement between Syngo.via and MIMneuro varied by region. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

PREFER-DMT: A Discrete Choice Experiment Framework for Eliciting Stakeholder Preferences on Disease-Modifying Therapy Implementation in European Healthcare Systems

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square

Key finding: Simulation-based validation demonstrates the framework’s analytical capability. +4 more findings

• Treatments

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

A Simulation-Based Discrete Choice Experiment Framework for Alzheimer’s Disease-Modifying Therapy Implementation: Methodology and Interactive Decision Support Tool

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square

Key finding: Under calibrated simulation parameters, slowing of cognitive decline emerged as the most important attribute (relative importance 25.7%), followed by annual cost (17.6%), ARIA risk (15.4%), and travel to treatment centre (13.0%). +4 more findings

• Treatments

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: unraveling the interplay with risk of dementia

49/100 ✓ Peer-reviewed Biomarkers Scientific Reports

Key finding: In total, 881 (21.6%) participants had ILF and 272 (6.8%) participants developed dementia. +4 more findings

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

Cognitive and Brain Reserve as Modifiers of Early Alzheimer Disease–Related Cognitive Vulnerability

61/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: A total of 621 participants (aged 69.9 ± 3.8, 71% female) had available data for the main analyses and 355 had PET Centiloid data available. +4 more findings

Full summary, score breakdown and related studies → Original source

Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: unraveling the interplay with risk of dementia

49/100 ✓ Peer-reviewed Tau biomarkers Scientific reports

Key finding: Impaired lung function (ILF) has been associated with cognitive decline and dementia risk in multiple cohorts, yet the role of circulating Alzheimer disease (AD) biomarkers in this relationship is not well understood. +3 more findings

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

A multidomain intrinsic capacity score tracks longitudinal health trajectories in the UK Biobank

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: We found that composite IC declined non-linearly with age, and within-person decline was steeper than the cross-sectional age measures. +2 more findings

• Risk Factors

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

45/100 ✓ Peer-reviewed Genetics Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Key finding: Individuals with Alzheimer's disease (AD) are at an increased risk of bone fracture, while osteoporosis in women is one of the earliest predictors of AD. +4 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Association Between Regular Dental Scaling and Risk of Dementia in Patients With Moderate to Severe Periodontitis Longitudinal Study Using Korean National Health Insurance Service-National Health Screening Cohort Data Base

33/100 ✓ Peer-reviewed Health systems and care delivery International journal of dental hygiene

Key finding: Landmark analyses were conducted to further strengthen the reliability of the results. +1 more finding

• Risk Factors
• Policy
• Diagnosis

Full summary, score breakdown and related studies → Original source

Automated Imaging Differentiation for Dementia

46/100 ✓ Peer-reviewed Inflammation and the immune system Neurology Open Access

Key finding: Free-water (FW) imaging has been investigated in neurodegenerative diseases and was found to be associated with neurodegeneration and neuroinflammation.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Healthcare provider adoption of cognitive assessment and care planning services associated with uptake among peers

35/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia Behavior & Socioeconomics of Aging

Key finding: Being exposed to a peer who adopted CACP was a strong predictor of providers’ own uptake of CACP. +1 more finding

• Diagnosis

Full summary, score breakdown and related studies → Original source

Urban Density-Dependent Effects of Neighborhood Park Spatial Features: Evidence from the Seoul Metropolitan Area

29/100 ✓ Peer-reviewed Risk factors Sustainability

Key finding: The study finds that the spatial elements of neighborhood parks have significantly varying effects on user satisfaction based on urban density. +2 more findings

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Engineered Alzheimer Organoids Validate the Link Between Intracellular and Soluble p-Tau Biomarkers and Highlight the Contribution of Astrocytic Tau

35/100 ✓ Peer-reviewed Tau biomarkers Neuroscience bulletin

Key finding: Here, we utilized chimeric human cerebral organoids (chCOs) to generate a series of organoids in which the endogenous MAPT gene was CRISPR/Cas9 edited in different cell types to create phosphorylation-deficient mutants at the AD-associated sites. +3 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Grip strength modifies the association between blood-based alzheimer's biomarkers and cognitive function

41/100 ✓ Peer-reviewed Tau biomarkers GeroScience

Key finding: Grip strength, a marker of frailty and functional reserve, may modify this relationship. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Plasma phosphorylated tau 217 detects amyloid-β in neuronal synuclein disease

63/100 ✓ Peer-reviewed Biomarkers NPJ Parkinson's disease

Key finding: In the discovery cohort, plasma pTau217, pTau181, Aβ42/40, and GFAP significantly differed by amyloid-β status regardless of NSD status, while NfL was highest in NSD+/Aβ+ participants. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Cerebral small vessel disease burden relates to cognitive decline via impaired amyloid clearance in the general population

52/100 ✓ Peer-reviewed Vascular contributions Journal of Cerebral Blood Flow & Metabolism

Key finding: Greater CSVD burden was significantly associated with poorer cognition ( B = −2.607 ± 1.016, β = −0.167, p = 0.010), with white matter hyperintensity volume (∆ R 2 = 0.3%, p = 0.016) and brain parenchymal fraction (∆ R 2 = 0.4%, p = 0.019) contributing most strongly. +1 more finding

• Other Dementias
• Risk Factors
• Diagnosis

Full summary, score breakdown and related studies → Original source

Associations of Accelerated Biological Aging With the Presence and Longitudinal Progression of Cerebral Small Vessel Disease

51/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: = 0.028), but not with progression of BG-EPVS or WMHs at follow-up. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Neuroinflammation in vascular cognitive impairment and dementia: Insights from clinical biomarkers and experimental models

41/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Cerebral Blood Flow & Metabolism

Key finding: Accumulating evidence from both clinical and basic studies suggests that neuroinflammation is one of the major mechanisms underlying VCID pathogenesis. +1 more finding

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Artificial intelligence in dementia care: challenges, controversies, and policy implications

37/100 ✓ Peer-reviewed Digital health tools Frontiers in Dementia

Key finding: This Perspective examines the opportunities and challenges of AI in dementia policies and services, focusing on equity, privacy, accountability, and the risk that technologies displace human care. +4 more findings

• Digital Tools
• Policy

Full summary, score breakdown and related studies → Original source

Mendelian randomization study of genetic interactions between Alzheimer disease and celiac disease

36/100 ✓ Peer-reviewed Genetics Medicine

Key finding: In the prospective analysis, the results indicated that genetic susceptibility to CeD was associated with a decreased risk of AD (IVW OR = 0.97, 95% CI = 0.95-0.99, P = .03). +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Analytical and Clinical Validity of a High-Throughput, Fully Automated Immunoassay for Plasma Neurofilament Light Chain

35/100 ✓ Peer-reviewed Biomarkers The Journal of Applied Laboratory Medicine

Key finding: The NfL assay met analytical criteria, with precision demonstrating coefficients of variation <3% across runs, a lower limit of quantification of 3.10 pg/mL, linearity with <12% deviation, and <10% interference. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source