Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 101–125 of 27,380 studies, newest first · page 5 of 1096.
October 2026 25
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2026-10-21
A brain immune phenotype independent of Alzheimer’s Disease associates with amyloid susceptibility and systemic inflammation
16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology bioRxiv
Key finding: Transcriptomic and proteomic studies have consistently demonstrated substantial molecular heterogeneity across patients with Alzheimer’s disease (AD) and other neurodegenerative disorders, leading to the proposal of multiple disease subtypes. +2 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-21
Multi-omics framework prioritizes RNA Methylation Modification Genes in Alzheimer's Disease and Functional Validation of ZFP36 in Regulating Neuroinflammation
16/100 ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system Research Square
Key finding: Single‑cell RNA‑seq of human prefrontal cortex samples revealed high ZFP36 expression in microglia, T cells and astrocytes. +2 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-21
Function-oriented microglial transcriptional scores in Alzheimer’s disease: resolving terminal functions beyond activation states
16/100 ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system bioRxiv
Key finding: In external GSE146639, eight modules remained FDR-significant, although harmful and adaptive arms are highly collinear; H7 and A2 are replicated in external proteomics.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-21
Feature harmonization reveals that apparent cross-cohort differences in tau-positivity prediction reflect variable availability and cohort stage structure
16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv
Key finding: In the primary matched-feature comparison, reference areas under the receiver operating characteristic curve (AUCs) were 0.851 for ADNI tau90, 0.860 for ADNI tau180, and 0.933 for OASIS3 tau180. +2 more findings
Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-21
Spatial proximity to AD pathology defines cell-type and genotype-specific characteristics in human AD hippocampus
16/100 ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv
Key finding: We characterized variants from 120 gene loci associated with AD risk that affect cell-specific gene expression within local pathological contexts.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-21
Discovery of a brain-penetrant CHI3L1 inhibitor as an oral modulator of neuroinflammation in Alzheimers disease
16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers bioRxiv
Key finding: Biophysical and crystallographic studies showed that DELC2 binds the CHI3L1 glycan-recognition groove within an aromatic-hydrophobic pocket centered on Trp99 and Trp352. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-21
Multimodal mediators connecting APOE4 to dementia
16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square
Key finding: We revealed graded, allele dosage‑dependent risk elevations for ACD, AD and VaD among APOE4 carriers, whereby homozygous carriers exhibited substantially higher incident dementia risk relative to heterozygous carriers and non‑carriers across all three clinical endpoints. +4 more findings
Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-21
Plasma biomarkers and incident clinical stage progression in the specialized memory clinic: a longitudinal study
16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv
Key finding: These findings support plasma biomarkers for disease identification and risk stratification while underscoring the need for population□specific approaches. +3 more findings
Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Interpretable Phenotype Discovery Using Temporal Risk-Aware Clustering
16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies medRxiv
Key finding: A dual-attention mechanism further supports interpretation by identifying the visits and clinical variables most associated with each phenotype assignment. +1 more finding
Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Integrating Multisource Target Evidence with Machine-Learning Potency Prediction for Alzheimer’s Disease Drug Discovery
16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools bioRxiv
Key finding: The platform connects curated evidence, model-ready datasets, reproducible evaluation, and public results while clearly separating contextual evidence from therapeutic claims and random-split performance from generalization to unseen chemical scaffolds.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
BNIP3L/NIX-mediated mitophagy limits Alzheimer’s disease pathology and preserves neuronal function
16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv
Key finding: Together, these findings identify BNIP3L/NIX-mediated mitophagy as a mechanistic link between mitochondrial quality control, proteostasis and neuronal function, and establish its restoration as a potential strategy for counteracting AD-associated pathology.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Coordinated cellular responses track cognitive outcomes in Alzheimer’s disease
16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology Research Square
Key finding: Higher pathology-adjusted responses were associated with lower relative abundance of vulnerable excitatory and somatostatin-expressing inhibitory neurons and poorer cognitive outcomes. +2 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Protective or Pathogenic? Microglial Responses at the Intersection of Amyloid-β, Tau, and Neuroinflammation in Alzheimer’s Disease
16/100 ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system Preprints.org
Key finding: These findings highlight the dual role of microglia in AD, functioning as both protective responders and potential drivers of neuroinflammation and neurodegeneration.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
An interpretable whole-blood transcriptomic model for Parkinson’s disease identification and molecular profiling
16/100 ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system medRxiv
Key finding: ORIGIN-PD enables rational enrichment for NLRP3/NF-κB inhibitor trials by identifying patients with inflammatory involvement. +2 more findings
Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Astrocytic sEH–EET signaling regulates microglial lysosomal function and suppresses the STING–Type I interferon pathway in Alzheimer’s disease
16/100 ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system bioRxiv
Key finding: We define an astrocyte–microglia axis in which astrocytic sEH limits EET availability and thereby sustains microglial STING signaling.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization
16/100 ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system bioRxiv
Key finding: Treatment of mouse microglial cells (MMCs) with 50 nM 37 °C oligomers elicited a robust pro-inflammatory cytokine response that exceeded that of monomeric Aβ42, as demonstrated by Luminex multiplex profiling and principal component analysis. hiPSC-derived microglia (iMGs) treated with 1 µM oligomers also separated from vehicle, establishing activity in a human cellular model. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Proteomic Signatures of Vulnerability Across Late-Life Depression, Frailty, and Neurodegeneration
16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Preprints.org
Key finding: Late-life depression (LLD) is increasingly recognized as a complex multisystem disorder associated with accelerated biological aging, impaired physiological resilience, frailty, and an increased risk of cognitive decline and dementia. +2 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
From Dementia Prevention Literacy to Preventive Agency: A Proposed Theoretical Framework for Translating Knowledge into Action
16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Preprints.org
Key finding: It provisionally conceptualises preventive agency as the situated capacity, exercised alone or with others, to interpret prevention evidence, evaluate its personal significance, exercise informed choice and identify actions that are achievable within one’s circumstances. +4 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Interacting Role of Social Determinants of Health and Hearing Loss on Cognitive Decline: An ACTIVE Longitudinal Study
16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square
Key finding: These findings indicate that the cognitive impact of hearing loss depends on structural resources, highlighting the need to integrate sensory health and social context in dementia prevention efforts. +4 more findings
Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Stable and Interpretable Cognitive Status Screening Using Longitudinal Wearable Data
16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square
Key finding: These findings support risk screening and hypothesis generation rather than diagnosis or validated biomarker claims; external multicenter validation is needed.
Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Natural Sesquiterpenoids from Laggera pterodonta as bioactive Acetylcholinesterase Inhibitors: Insights from DFT, Molecular Docking, and ADMET Profiling
16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square
Key finding: Density functional theory (DFT) at the B3LYP/6-311G (d, p) level elucidated the electronic structures of these compounds, including frontier molecular orbitals, density of states, global reactivity descriptors, molecular electrostatic potential, non-covalent interaction topology, and electron localization, while time-dependent DFT further identified their optical signatures Molecular docking showed that all five natural compounds interacted with the AChE active site with binding affinities closer to galantamine; HM-1 had the highest binding value of all (-8.6 kcal/mol ), inducing stable interactions via hydrogen bonding and π-mediated contacts inside the catalytic cavity of the enzyme. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Predictive EEG Signatures of Alzheimer's Disease: A Cross-Validated, Cross-Method Analysis Using ANCOVA Filtering and Sparse Logistic Regression
16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square
Key finding: Taken together, the results point to a real but modest EEG signature of AD in this dataset, identified using a validation design built specifically so that reported accuracy reflects genuine generalization rather than an artifact of how the features were selected.
Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Functional neuroimaging as a tool to understand social determinants of health in cognitive aging and ADRD: a scoping review
16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging PsyArXiv
Key finding: The social, structural, and physical conditions in which individuals live, work, and age, collectively termed social determinants of health (SDOH), are associated with risk of Alzheimer's disease and related dementias (ADRD). +1 more finding
Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Too early for LATE? Age at onset is associated with the clinical and neuroimaging expression of limbic-predominant age- related TDP-43 pathology in Alzheimer’s disease
16/100 ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE medRxiv
Key finding: LATE-NC occurred in 31% overall and 19% of individuals with symptom onset ≤65 years. +2 more findings
Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-10-20
Longitudinal single-cell transcriptional profiling identifies dynamic neurodegenerative mechanisms in Christianson Syndrome rat
16/100 ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE bioRxiv
Key finding: Together, our findings define the cellular trajectories of neurodegeneration in CS, and identify convergent endolysosomal, mitochondrial, and inflammatory mechanisms that support a broader role for endolysosomal dysfunction in Alzheimers disease pathogenesis.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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