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The In Vitro Multifaceted Biological Activity of Catechins in Relation to Their Oxidation Potentials
Małgorzata Wronkowska, Danuta Zielińska, Małgorzata Starowicz, Mateusz Szydłowski, Mariusz Konrad Piskuła, Henryk Zieliński. Molecules, 2026-04-17
Topic: Brain proteins, microglia and lab models
In this study, the rank of multifaceted activity of catechin (C), epicatechin (EC), epigallocatechin (EGC), epicatechin-3-gallate (ECG) and epigallocatechin-3-gallate (EGCG) was addressed. Their antioxidant activity was determined by the differential pulse voltammetry (DPV), whereas their ability to inhibit angiotensin-converting enzyme (ACE) activity, acetylcholinesterase activity (AChE), and formation of the advanced glycation end-products (AGEs) was performed in a model system to show their importance against hypertension, Alzheimer-type dementia, and diabetic’s complication, respectively. The order of the antioxidant potential of catechins in comparision to gallic acid (GA) was EGCG > ECG > EC > EGC ≈ C > GA, whereas the order of the ACE inhibitory activity was EGCG > ECG > EGC > EC > C, thus indicating the importance of the structure–activity relationship. The correlation between IC50 for ACE inhibition of catechins and their antioxidant activity had the value r = −0.60. The order of the AChE enzyme inhibitory activity was EGCG ≈ EGC > ECG > EC > C, and the weak positive correlation between IC50 and the first anodic peak potential (Epa1) values was noted (r = 0.67). The ranking of the anti-AGE activities was EGCG ≈ ECG > EGC > EC > C, and a negative correlation between the inhibitory activity of catechins against AGE formation and their antioxidant activity was r = −0.82, whereas a positive correlation (r = 0.88) was noted between their first anodic peak potential (Epa1) values. The provided results expand our knowledge on the multifaceted activity of catechins, indicating EGCG and ECG as the most active antioxidants against inhibition of ACE and AChE as well as towards AGE formation.
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APA 7th
Wronkowska, M., Zielińska, D., Starowicz, M., Szydłowski, M., Piskuła, M. K., & Zieliński, H. (2026). The In Vitro Multifaceted Biological Activity of Catechins in Relation to Their Oxidation Potentials. Molecules. https://doi.org/10.3390/molecules31081328
Vancouver
Wronkowska M, Zielińska D, Starowicz M, Szydłowski M, Piskuła MK, Zieliński H. The In Vitro Multifaceted Biological Activity of Catechins in Relation to Their Oxidation Potentials. Molecules. 2026. doi:10.3390/molecules31081328. PMID: 42076005.
BibTeX
@article{wronkowska2026-42076005,
author = {Wronkowska, Małgorzata and Zielińska, Danuta and Starowicz, Małgorzata and Szydłowski, Mateusz and Piskuła, Mariusz Konrad and Zieliński, Henryk},
title = {{The In Vitro Multifaceted Biological Activity of Catechins in Relation to Their Oxidation Potentials}},
journal = {Molecules},
year = {2026},
doi = {10.3390/molecules31081328},
pmid = {42076005},
url = {https://doi.org/10.3390/molecules31081328}
}
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Key findings
- The provided results expand our knowledge on the multifaceted activity of catechins, indicating EGCG and ECG as the most active antioxidants against inhibition of ACE and AChE as well as towards AGE formation.
Why it matters
In laboratory model systems, the catechins EGCG and ECG were the most active at inhibiting acetylcholinesterase and formation of advanced glycation end-products, alongside antioxidant effects. These are in vitro findings relevant to Alzheimer-type dementia, not evidence of benefit in patients.
Study details
- Evidence strengthLow
How this study scored 37/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Molecules) |
| Journal's citation record | 3 / 4 | Molecules: journal h-index 349 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “in vitro”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.5 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 3 / 6 | Cited 4.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Henryk Zieliński: h-index 46 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Warmia and Mazury in Olsztyn: institution h-index 198 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42076005) |
| Free to read | 2 / 2 | Free to read |
| Total | 37 / 100 | — |
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