Newest studies

Genetic insights into immune mechanisms of Alzheimer's and Parkinson's disease

41/100 ✓ Peer-reviewed Genetics Frontiers in immunology

Key finding: In this review, we discuss the key concepts and challenges in the post-GWAS interpretation of AD and PD GWAS risk alleles. +4 more findings

• Genetics
• Other Dementias

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Comparative evaluation of clinical and cerebrospinal fluid biomarker characteristics in rapidly and non-rapidly progressive Alzheimer's disease

54/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: Lower CSF Amyloid beta 1-42 concentrations (p = 0.048), lower Amyloid beta 42/40 ratio (p = 0.038), and higher Tau/Amyloid-beta 1-42 ratio, as well as pTau/Amyloid-beta 1-42 ratio (each p = 0.004) were associated with rpAD. +4 more findings

• Biomarkers

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Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease

52/100 ✓ Peer-reviewed Risk genes beyond APOE Aging cell

Key finding: We hypothesized that this interindividual variability may be associated with the location of the pathogenic variant within PSEN1. +2 more findings

• Genetics
• Biomarkers

Full summary, score breakdown and related studies → Original source

Disparities in brain health comorbidity management in intracerebral hemorrhage

58/100 ✓ Peer-reviewed Risk factors Frontiers in Neurology

Key finding: The study included 234 patients (mean 71 years, 42% female). +4 more findings

• Risk Factors
• Health Equity

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Association of earlier age at menopause with risk of incident dementia, brain structural indices and the potential mediators: a prospective community-based cohort study

64/100 ✓ Peer-reviewed Long-term cohort studies EClinicalMedicine

Key finding: In addition, the underlying mechanism and driven mediators are largely unknown. +3 more findings

• Risk Factors

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Dysbiosis and Alzheimer's disease: role of probiotics, prebiotics and synbiotics

41/100 ✓ Peer-reviewed Disease mechanisms Naunyn-Schmiedeberg's archives of pharmacology

Key finding: Restoration of levels of beneficial microorganisms in the gut has demonstrated promising effects in AD in pre-clinical and clinical studies.

• Brain Biology

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Development of software for measuring brain amyloid accumulation using 18 F-florbetapir PET and calculating global Centiloid scale and regional Z-score values

41/100 ✓ Peer-reviewed Brain scans and imaging Brain and behavior

Key finding: The CL calculation was validated with the 18 F-florbetapir dataset in the GAAIN repository. +3 more findings

• Brain Scans

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Intersection of multiple factors shape Korean American caregiver experience in dementia caregiving

48/100 ✓ Peer-reviewed Caregiving Aging & mental health

Key finding: Three themes were identified; 1) intersectionality in the Korean American caregiver experience, 2) complex family dynamics, and 3) dementia care barriers and caregiver support needs. +4 more findings

• Caregiving

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Long-term exposure to low-level air pollution, genetic susceptibility and risk of dementia

50/100 ✓ Peer-reviewed Risk factors International journal of epidemiology

Key finding: The adjusted hazard ratio (HR) of dementia for a 5-μg/m3 increase in NO2 was 1.09 (95% CI, 1.05-1.14); the adjusted HR of dementia for a 1-μg/m3 increase in PM2.5 was 1.10 (1.04-1.17). +4 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Representativeness of samples enrolled in Alzheimer's disease research centers

57/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Sociodemographic and health characteristics across ethnoracial groups included in the National Alzheimer's Coordinating Center sample (NACC) were compared to the nationally representative Health and Retirement Study (HRS). +3 more findings

• Health Equity

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Unsupervised [18F]Flortaucipir cutoffs for tau positivity and staging in Alzheimer's disease

54/100 ✓ Peer-reviewed Brain scans and imaging European journal of nuclear medicine and molecular imaging

Key finding: GMM-based cutoffs classified less subjects as T+, mainly in the A- CN (<3.4% vs >28.5%) and A+ CN (<14.5% vs >42.9%) groups and showed higher agreement with visual rating (ICC=0.91 vs ICC<0.62) than published cutoffs. +2 more findings

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The triggering receptor expressed on myeloid cells 2-apolipoprotein E signaling pathway in diseases

41/100 ✓ Peer-reviewed TREM2 and immune genetics Chinese medical journal

Key finding: Recently, TREM2 has received extensive attention from researchers, and its activity has been found in Alzheimer's disease, neuroinflammation, and traumatic brain injury. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Minocycline for sporadic and hereditary cerebral amyloid angiopathy (BATMAN): study protocol for a placebo-controlled randomized double-blind trial

53/100 ✓ Peer-reviewed Inflammation and the immune system Trials

Key finding: The results of this proof-of-principle study will be used to assess the potential of target engagement of minocycline for CAA.

• Clinical Trials
• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization

43/100 ✓ Peer-reviewed Inflammation and the immune system Theranostics

Key finding: High-intensity interval training (HIIT) alleviates cognitive dysfunction in STZ-induced AD-like rat models and provides neuroprotection against neurodegeneration, neuronal damage, and neuronal loss. +4 more findings

• Brain Biology

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Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway

41/100 ✓ Peer-reviewed Inflammation and the immune system Molecular neurobiology

Key finding: We found that complement C3 is upregulated in lipopolysaccharide (LPS)-stimulated neuron/glial cultures. +3 more findings

• Brain Biology

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Plasma biomarkers for prediction of Alzheimer's disease neuropathologic change

58/100 ✓ Peer-reviewed Biomarkers Acta neuropathologica

Key finding: Our goal was to investigate the utility of clinically available plasma markers in predicting Braak staging, neuritic plaque score, Thal phase, and overall AD neuropathological change (ADNC).We utilized a population-based prospective study of 350 participants with autopsy and antemortem plasma biomarker testing using clinically available antibody assay (Quanterix) consisting of Aβ42/40 ratio, p-tau181, GFAP, and NfL. +2 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease

54/100 ✓ Peer-reviewed Genetics Nature neuroscience

Key finding: Lastly, we show that APOE4 genotype-associated differences are significantly enriched among AD-associated genes in capillary and venule endothelial cells, as well as subsets of pericytes and fibroblasts.

• Genetics

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Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease

48/100 ✓ Peer-reviewed Biomarkers Neurobiology of disease

Key finding: Significant differences in plasma p-tau181 and p-tau231, but not plasma GFAP concentrations were present between the APOE4 gene doses, explained solely by brain Aβ load. +2 more findings

• Biomarkers

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β 2 -Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice

43/100 ✓ Peer-reviewed Drug development Nature neuroscience

Key finding: Extensive studies indicate that β-amyloid (Aβ) aggregation is pivotal for Alzheimer's disease (AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to trigger AD-associated degeneration, and whether other additional pathological factors drive AD pathogenesis remains unclear. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

The relationship between social determinants of health and hospitalization among American Indian and Alaska native older adults with and without dementia

32/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Understanding and addressing SDOH associated with hospitalizations among AI/AN older adults, with and without dementia, may aid in the development of strategies that reduce preventable hospitalization. +2 more findings

• Care Services
• Health Equity

Full summary, score breakdown and related studies → Original source

In the context of a deprived neighborhood, does self‐identified race cause dementia?

48/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: A higher degree of neighborhood disadvantage may contribute to the excess risk of MCI or dementia found among AA. +4 more findings

• Risk Factors
• Health Equity

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Estimating Dementia Risk Using Multifactorial Prediction Models

69/100 ✓ Peer-reviewed Long-term cohort studies JAMA network open

Key finding: The clinical value of current multifactorial algorithms for individualized assessment of dementia risk remains unclear. +3 more findings

• Risk Factors

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Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease

66/100 ✓ Peer-reviewed Long-term cohort studies JAMA neurology

Key finding: Longitudinal tau positron emission tomography (PET) is a relevant outcome in clinical trials evaluating disease-modifying therapies in Alzheimer disease (AD). +3 more findings

• Brain Scans

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Tilavonemab in early Alzheimer's disease: results from a phase 2, randomized, double-blind study

82/100 ✓ Peer-reviewed Cognitive tests and assessment Brain : a journal of neurology

Key finding: This phase 2 study evaluated the safety and efficacy of tilavonemab, an anti-tau monoclonal antibody, in patients with early Alzheimer's disease. +3 more findings

• Clinical Trials

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Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness: A Randomized Clinical Trial

65/100 ✓ Peer-reviewed Disparities JAMA

Key finding: Among hospitalized older adults with serious illness, a pragmatic clinician-facing communication-priming intervention significantly improved documentation of goals-of-care discussions in the electronic health record, with a greater effect size in racially or ethnically minoritized patients. +2 more findings

• Clinical Trials
• Health Equity
• Care Services

Full summary, score breakdown and related studies → Original source