Newest studies

Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments

38/100 ✓ Peer-reviewed Genetics The EMBO journal

Key finding: When deregulated, ectodomain shedding is linked to pathologies such as inflammation and Alzheimer's disease. +4 more findings

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The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome

48/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Acta neuropathologica communications

Key finding: We found no evidence that tau pathology might commence within the brain in DS before amyloid deposition had occurred, but there was limited data that suggests tau pathology in LC or DRN might predate that in entorhinal areas and hippocampus or at least be coincident.

• Down Syndrome

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The Value of Unstructured Electronic Health Record Data in Geriatric Syndrome Case Identification

53/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

Key finding: Claims and structured EHR data give an incomplete picture of burden related to geriatric syndromes. +1 more finding

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Physical activity to improve cognition in older adults: can physical activity programs enriched with cognitive challenges enhance the effects? A systematic review and meta-analysis

64/100 ✓ Peer-reviewed Prevention and risk The international journal of behavioral nutrition and physical activity

Key finding: Forty-one studies were included. +1 more finding

• Prevention
• Lifestyle

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Stability of blood-based biomarkers of Alzheimer's disease over multiple freeze-thaw cycles

52/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Up to four freeze-thaw cycles do not influence single molecule array blood biomarkers of neurofilament light chain, total tau, or Aβ 42 , with at most minor reductions in Aβ 40 . +1 more finding

• Biomarkers

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Aging and Alzheimer's disease: Comparison and associations from molecular to system level

50/100 ✓ Peer-reviewed Risk factors Aging cell

Key finding: Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. +3 more findings

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The cholinergic system in the pathophysiology and treatment of Alzheimer's disease

41/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology

Key finding: Their high density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic transmission is likely to be critically important for memory, learning, attention and other higher brain functions. +1 more finding

• Treatments
• Brain Biology

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Visual and hearing impairments are associated with cognitive decline in older people

59/100 ✓ Peer-reviewed Risk factors Age and ageing

Key finding: This study aims to determine whether single and dual sensory impairment (hearing and/or vision) are independently associated with cognitive decline among older adults and to describe cognitive trajectories according to their impairment pattern. +2 more findings

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A novel electrochemical aptamer-antibody sandwich assay for the detection of tau-381 in human serum

38/100 ✓ Peer-reviewed Drug development The Analyst

Key finding: The responses of DPV measurements showed excellent results in this dynamic range.

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Tau-targeting therapies for Alzheimer disease

38/100 ✓ Peer-reviewed Drug development Nature reviews. Neurology

Key finding: In this article, we review the current status of tau-targeting therapies for AD. +4 more findings

• Treatments
• Brain Biology

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Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

38/100 ✓ Peer-reviewed Vascular contributions Science translational medicine

Key finding: We identified a loss-of-function mutation in ATPase11B, which caused the EC dysfunction in the rat SVD model, and a single-nucleotide polymorphism in ATPase11B that was associated with white matter abnormalities in humans with SVD.

• Other Dementias
• Treatments

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Cerebral small vessel disease: from a focal to a global perspective

38/100 ✓ Peer-reviewed Vascular contributions Nature reviews. Neurology

Key finding: Finally, we conclude that SVD should be considered a global rather than a focal disease, as the classically recognized focal lesions affect remote brain structures and structural and functional network connections.

• Other Dementias

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An Advance Care Planning Video Decision Support Tool for Nursing Home Residents With Advanced Dementia: A Cluster Randomized Clinical Trial

81/100 ✓ Peer-reviewed End-of-life care JAMA internal medicine

Key finding: The mean age of the 402 study residents was 86.7 years [range, 67-102 years]; 350 were white (87.1%) and 323 were female (80.3%), with DNH directives that by 6 months did not differ between arms (63% in both arms; adjusted odds ratio [AOR], 1.08; 95% CI, 0.69-1.69).

• Clinical Trials
• End-of-Life Care

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P3‐509: FEASIBILITY OF A DEMENTIA VILLAGE IN SINGAPORE

24/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: A dementia village is a novel concept, which would result in a more active, comprehensive and humane way for dementia patients to live, without being handicapped by their condition.

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Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated

66/100 ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology

Key finding: In amyotrophic lateral sclerosis and neocortical Lewy body disease, co-pathologies associated with APOE ɛ4. +1 more finding

• Other Dementias

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New horizons in falls prevention

42/100 ✓ Peer-reviewed Digital health tools Age and ageing

Key finding: Falls can result in fractures and other injuries, disability and fear and can trigger a decline in physical function and loss of autonomy. +1 more finding

• Digital Tools
• Prevention

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A lexical semantic hub for heteromodal naming in middle fusiform gyrus

54/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology

Key finding: We observed three stages of activity during both visual picture naming and auditory naming to definition that were serially organized: sensory processing, lexical semantic processing, and articulation. +1 more finding

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Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial

69/100 ✓ Peer-reviewed Treatments JAMA neurology

Key finding: This multicenter randomized clinical trial demonstrated the feasibility of sham-surgery-controlled stereotactic gene delivery studies in patients with AD. +2 more findings

• Clinical Trials
• Diagnosis

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Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum

47/100 ✓ Peer-reviewed Genetics JAMA neurology

Key finding: Among 124 876 cases and controls, genome-wide conjunction analyses of ALS, FTD, PD, AD, CBD, and PSP revealed significant genetic overlap between ALS and FTD at known ALS loci: rs13302855 and rs3849942 (nearest gene, C9orf72; P = .03 for rs13302855 and P = .005 for rs3849942) and rs4239633 (nearest gene, UNC13A; P = .03). +2 more findings

• Genetics
• Other Dementias
• Brain Biology

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Beta-amyloid imaging in dementia

39/100 ✓ Peer-reviewed Brain scans and imaging Yeungnam University journal of medicine

Key finding: Alzheimer's disease (AD) is a neurodegenerative disorder associated with extracellular plaques, composed of amyloid-beta (Aβ), in the brain.

• Brain Scans
• Brain Biology

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Plasma amyloid-β levels, cerebral atrophy and risk of dementia: a population-based study

51/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's research & therapy

Key finding: Plasma amyloid-β (Aβ) levels are increasingly studied as a potential accessible marker of cognitive impairment and dementia. +3 more findings

• Biomarkers
• Risk Factors

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Severe hypoglycaemia, mild cognitive impairment, dementia and brain volumes in older adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) cohort study

60/100 ✓ Peer-reviewed Long-term cohort studies Diabetologia

Key finding: We aimed to evaluate the link between severe hypoglycaemia and domain-specific cognitive decline, smaller brain volumes and dementia in adults with type 2 diabetes, which so far has been relatively poorly characterised. +3 more findings

• Risk Factors

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Loss of white matter integrity reflects tau accumulation in Alzheimer disease defined regions

48/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Our cohort was composed of 59 cognitively normal participants and 10 cognitively impaired individuals. +4 more findings

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Do We Need to Rethink the Epidemiology and Healthcare Utilization of Parkinson's Disease in Germany?

72/100 ✓ Peer-reviewed Digital health tools Frontiers in neurology

Key finding: The annual healthcare utilization was increased in PD cases compared to controls, e.g., regarding mean ± SD physician contacts (15.2 ± 7.6/12.2 ± 7.3), hospitalizations (1.3 ± 1.8/0.7 ± 1.4), drug prescriptions (overall: 37.7 ± 24.2/21.7 ± 19.6; anti-PD medication: 7.4 ± 7.4/0.1 ± 0.7), assistive/therapeutic devices (47/30%), and therapeutic remedies (57/16%). +1 more finding

• Treatments
• Other Dementias

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Concordance between Goals of Care and Treatment Decisions for Persons with Dementia

67/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine

Key finding: Most families chose comfort as the primary GOC. +3 more findings

• End-of-Life Care
• Treatments

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