Newest studies

Predicting Mild Cognitive Impairment to Alzheimer's Disease Progression by Explainable Multi‐Modal Framework Using Deep and Machine Learning Hybrid Model

35/100 ✓ Peer-reviewed Mild cognitive impairment International Journal of Imaging Systems and Technology

Key finding: Accurate prediction of the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) is essential for early intervention and effective disease management.

• Early Stage
• Digital Tools

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Optimizing Plasma p-tau217 Thresholds for Detection of Preclinical Alzheimer’s Disease Across Different Racial and Ethnic Backgrounds (P10-13.011)

33/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: To evaluate plasma p-tau217 ability to detect pre-symptomatic Alzheimer disease (AD) in ethnoracially diverse cognitively normal individuals.

• Biomarkers
• Health Equity
• Early Stage

Full summary, score breakdown and related studies → Original source

β-amyloid PET Signal Reduction in Regions with ARIA-E Following Anti-amyloid Therapy for Alzheimer Disease (P1-12.010)

32/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: To determine the relationship between regional brain edema caused by anti-amyloid monoclonal antibody therapy (ARIA-E) and the degree of regional β-amyloid (Aβ) positron emission tomography (PET) signal reduction.

• Treatments
• Brain Scans
• Side Effects

Full summary, score breakdown and related studies → Original source

Estimating the Effect of Hospital Admission on Health Care Outcomes and Spending Among Persons With Dementia : A Quasi-experimental Study

74/100 ✓ Peer-reviewed Costs and economics Annals of internal medicine

Key finding: Among Medicare beneficiaries with dementia who visited an ED, there was no evidence that hospital admission was associated with mortality rates. +4 more findings

• Policy
• Care Services

Full summary, score breakdown and related studies → Original source

Connecting the Dots in Parkinson’s care: A Rapid Review and Qualitative Synthesis of Multidisciplinary Patient Passports for Parkinson’s disease

16/100 ⚠ Preprint — not yet peer-reviewed End-of-life care Research Square

Key finding: Forty‑two studies published between 1997 and 2025 were included.

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Epigenetic Age and Resilience in the Framingham Heart Study

74/100 ✓ Peer-reviewed Tau biomarkers Neurology open access

Key finding: Independent of t-tau and TCBV, epigenetic age measures were associated with time to MCI, AD, and all-cause dementia and baseline cognition, but not with cognitive trajectories. +4 more findings

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Bias from small-count suppression in county-level cancer disparity estimates: a calibrated simulation study

37/100 ✓ Peer-reviewed Risk factors Not indexed

Key finding: The suppressed fraction rose with rarity: 7.4% of counties for breast, 61.3% for stomach, and 75.7% for cervix incidence. +1 more finding

• Health Equity

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The role of inflammation in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications

51/100 ✓ Peer-reviewed Vascular contributions International Journal of Stroke

Key finding: Considerable data support the presence of both systemic and CNS inflammation in SVD and VCID. +2 more findings

• Other Dementias
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Early recognition of delirium in hospitalized patients: an underutilized clinical priority

33/100 ✓ Peer-reviewed Clinical safety Annals of Medicine and Surgery

Key finding: Importantly, delirium is not merely a transient cognitive fluctuation; it is independently associated with increased short- and long-term mortality, longer hospital stays, higher healthcare costs, and persistent cognitive impairment comparable to mild dementia[4,5]. +4 more findings

• Care Services

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Characterization of the Anti-Alzheimer Drug Lecanemab by Mass Spectrometry

36/100 ✓ Peer-reviewed Treatments ACS Omega

Key finding: These results provide data as resource for the identification of critical quality attributes of lecanemab in studying its therapeutic effectiveness, side effects, and possible batch-to-batch qualities.

• Treatments

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Socioeconomic disparities and nutritional aging: how food insecurity and financial hardship accelerate health decline in older adults

41/100 ✓ Peer-reviewed Risk factors Frontiers in Nutrition

Key finding: Food insecurity and financial hardship are consistently associated with poorer diet quality, including lower Healthy Eating Index scores (e.g., ~51 vs. >57 in food-secure peers), and increased risk of adverse outcomes such as sarcopenia, frailty, and cognitive decline.

• Health Equity
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Dementia and Frailty Impact Postoperative Care Trajectories and Burden among Older Adults Undergoing Radical Cystectomy for Bladder Cancer

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics medRxiv

Key finding: Patients with dementia were more likely to be frail, comorbid, and not receive standard-of-care neoadjuvant chemotherapy. +2 more findings

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Revisão sistemática: Biomarcadores séricos no diagnóstico precoce da doença de Alzheimer

28/100 ✓ Peer-reviewed Tau biomarkers Research Society and Development

Key finding: Foi realizada uma busca sistemática nas bases de dados PubMed, Scopus e Web of Science, utilizando descritores relacionados à doença de Alzheimer, biomarcadores séricos e diagnóstico precoce. +4 more findings

• Biomarkers

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TDP-43 oxidation and PP1 crosstalk at RNA granule-mitochondria contact sites

41/100 ✓ Peer-reviewed Brain tissue and pathology Nature Communications

Key finding: This dynamic crosstalk between TDP-43 oxidation and PP1 has significant consequences for TDP-43-associated diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).

• Brain Biology

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Blood-based biomarkers for early diagnosis of Alzheimer's disease: a current systematic review of diagnostic accuracy studies

51/100 ✓ Peer-reviewed Tau biomarkers BMC neurology

Key finding: Alzheimer disease (AD) is the most common cause of dementia in the world and its prevalence is increasing and it has important public health consequences. +3 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Inflammation Associated With Obesity, Aging, and Amyloid Burden in Adults With Down Syndrome

37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Obesity (Silver Spring, Md.)

Key finding: The majority of the participants met criteria for obesity. +1 more finding

• Down Syndrome
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Assessment of potentially inappropriate medications using STOPPFrail V2 criteria and OncPal guideline in elderly cancer patients with end-stage disease: A cross-sectional study

16/100 ⚠ Preprint — not yet peer-reviewed End-of-life care Research Square

Key finding: Polypharmacy and PIMs are highly prevalent in end-of-life elderly cancer patients. +2 more findings

• End-of-Life Care
• Treatments

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Reducing placebo response in clinical trials of agitation in Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: Meta-regression identified several factors associated with increased placebo response, but most of these factors were non-specific such that they predicted improvements in drug response as well. +3 more findings

• Clinical Trials
• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

The gut-brain axis in Alzheimer's disease: early detection, microbial metabolites, mechanisms, and therapeutic opportunities

61/100 ✓ Peer-reviewed Disease mechanisms Frontiers in molecular biosciences

Key finding: Emerging evidence indicates that microbial dysbiosis may influence key processes leading to AD, including neuroinflammation, amyloid and tau pathology, and cognitive decline. +2 more findings

• Treatments
• Brain Biology
• Diagnosis

Full summary, score breakdown and related studies → Original source

Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience

50/100 ✓ Peer-reviewed Genetics Nature medicine

Key finding: Together, these findings highlight divergent resilience-associated mechanisms in human aging and position microglial state transitions at the Aβ-tau interface as candidate points of resilience with potential therapeutic relevance.

• Brain Biology

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Using the ascertain dementia eight-item questionnaire to identify at-risk older surgical patients

60/100 ✓ Peer-reviewed Clinical safety Journal of Clinical Anesthesia

Key finding: Of 689 participants, CI was associated with delirium (adjusted odds ratio [aOR]: 3.64, 95% CI: 1.31, 9.49, P-value = 0.009), 90-day complications (aOR: 2.26, 95% CI: 1.14, 4.28, P-value = 0.015), and 90-day composite adverse outcomes (aOR: 2.03, 95% CI: 1.03, 3.81, P-value = 0.033). +4 more findings

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Differences in amyloid PET positivity based on ethnoracial group and social determinants of health: The new IDEAS study

41/100 ✓ Peer-reviewed Risk factors Carolina Digital Repository (University of North Carolina at Chapel Hill)

Key finding: Among 5757 participants (21.7% Black, 20.3% Latinx, 58.1% AORE), we found lower odds of amyloid positivity in Black (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.62-0.83) and Latinx (OR: 0.78, 95% CI: 0.67-0.91) compared to AORE. +3 more findings

• Brain Scans
• Health Equity

Full summary, score breakdown and related studies → Original source

Chicago ZIP Code-Linked Area Deprivation Index as a Predictor of Dementia Diagnosis

30/100 ✓ Peer-reviewed Risk factors University of Chicago

Key finding: In this study, we examined whether a neighborhood-level, integrative measure of socioeconomic deprivation, the Area Deprivation Index (ADI), is associated with dementia diagnosis in the City of Chicago using archival data from neuropsychological evaluations from 2017-2025. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Chicago ZIP Code-Linked Area Deprivation Index as a Predictor of Dementia Diagnosis

41/100 ✓ Peer-reviewed Risk factors Knowledge@UChicago (University of Chicago)

Key finding: In this study, we examined whether a neighborhood-level, integrative measure of socioeconomic deprivation, the Area Deprivation Index (ADI), is associated with dementia diagnosis in the City of Chicago using archival data from neuropsychological evaluations from 2017-2025. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Consistency of a Dementia Diagnosis Between Systems for Patients Receiving Care Through the VA, Traditional Medicare, and Medicare Advantage

54/100 ✓ Peer-reviewed Health systems and care delivery Medical Care

Key finding: For VA and Medicare cohorts, dementia diagnosis was absent in 88.7% and 80.5%, respectively, of follow-up encounters in the other system. +4 more findings

• Diagnosis
• Policy

Full summary, score breakdown and related studies → Original source