Newest studies

Spatial Distribution and Determinants of Hypertension Prevalence at The Subdistrict Level: A Small-Area Ecological Cross-Sectional Study

33/100 ✓ Peer-reviewed Risk factors Research in Community and Public Health Nursing

Key finding: The prevalence of hypertension showed statistically significant spatial clustering (global Moran’s I=0.442, p<.001), with high-high clusters concentrated in rural eup-myeon areas and low-low clusters in urban dong areas. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions

58/100 ✓ Peer-reviewed Vascular contributions Nature Communications

Key finding: White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative etiology.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study

38/100 ✓ Peer-reviewed Disease mechanisms Journal of Clinical Investigation

Key finding: In the current issue, Zakiniaeiz et al. demonstrate that AUD and alcohol consumption are associated with lower synaptic vesicle glycoprotein 2a (SV2A) expression, indexed by regional [11C]UCB-J PET. +1 more finding

• Brain Scans
• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

SHP2 in microglia attenuates neuroinflammation and cognitive deficits in vascular dementia by modulating the FAK/Src/PU. 1/IRF8 pathway

35/100 ✓ Peer-reviewed Inflammation and the immune system European journal of medical research

Key finding: Our findings suggest that SHP2 within microglia may inhibit the progression of vascular dementia by suppressing the FAK/Src/PU. 1/IRF8 pathway-mediated neuroinflammatory response.

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia

50/100 ✓ Peer-reviewed Lewy body dementia Nature Communications

Key finding: Together, these findings demonstrate that mutant Tau directly perturbs cellular clearance pathways and suggest that boosting autophagy may help restore Tau homeostasis in tauopathies.

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Quality Gaps in Online Media Coverage of Antiamyloid Monoclonal Antibodies for Alzheimer Disease

42/100 ✓ Peer-reviewed Treatments JAMA Network Open

Key finding: This cross-sectional study examines the quality of information on Alzheimer disease (AD) monoclonal antibodies presented by news websites.

• Treatments

Full summary, score breakdown and related studies → Original source

A deep joint-learning proteomics model for diagnosis of six conditions associated with dementia

62/100 ✓ Peer-reviewed Getting a diagnosis Nature medicine

Key finding: Here we present Proteomics-based Artificial Intelligence for Dementia Diagnosis (ProtAIDe-Dx), a deep joint-learning model on 17,187 patients and controls (age of 70.3 ± 11.5 years, 53.2% female), that uses plasma proteomics to provide simultaneous probabilistic diagnosis across 6 conditions associated with dementia in aging. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Dementia and End-of-Life Shared Decision-Making Among Older US Adults

45/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

Key finding: Findingss: uggested that dementia reshaped the structure and intensity of the shared decision-making process by increasing surrogate engagement and decisional demands, underscoring the importance of early advance care planning and structured support for family caregivers to sustain goal-concordant care. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Air Pollution, Health, and Economics: Evaluating the Impact of WHO targets and Guideline Values on Mortality and Morbidity in Low- and Middle-Income Countries

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: Direct medical and productivity-related costs associated with incident cases were estimated using a cost-of-illness (COI) framework. +3 more findings

• Risk Factors
• Policy

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Phenotypic heterogeneity of type 2 diabetes and risks of complications with a tree-like representation

59/100 ✓ Peer-reviewed Risk factors Cardiovascular diabetology

Key finding: This study included 6406 individuals with newly diagnosed type 2 diabetes from the UK Biobank. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Independent and interactive contributions of white matter hyperintensities and Alzheimer’s disease imaging and plasma biomarkers to cognitive decline in older adults without dementia

41/100 ✓ Peer-reviewed Vascular contributions Alzheimer s Research & Therapy

Key finding: Individual biomarkers significantly predict decline across multiple cognitive domains. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Clinicopathological features of primary tauopathies: a brain bank series

38/100 ✓ Peer-reviewed Disease mechanisms Frontiers in Neurology

Key finding: Fifteen cases were identified, spanning argyrophilic grain disease, primary age-related tauopathy, corticobasal degeneration, genetic frontotemporal dementia, and progressive supranuclear palsy. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

High-Level Alzheimer Disease Neuropathological Change Following Iatrogenic Exposure

51/100 ✓ Peer-reviewed Brain tissue and pathology JAMA Neurology

Key finding: The study describes 4 males who developed dementia following confirmed or suspected c-hGH treatment in childhood (age at symptom onset between 47 and 60 years) with cognitive syndromes characterized by prominent language involvement. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Cognitive Trajectories from Preclinical Alzheimer's Disease to Dementia

46/100 ✓ Peer-reviewed Getting a diagnosis Advanced Science

Key finding: These findings demonstrate that cognitive measures differ markedly in their sensitivity across the AD continuum.

• Early Stage

Full summary, score breakdown and related studies → Original source

Exploring immediate responses to APOE ε 4/ε4 genotype and Alzheimer's disease risk disclosure in Latinos

44/100 ✓ Peer-reviewed Genetics Journal of Alzheimer s Disease

Key finding: Among most Latinos in northern Manhattan who learned they had an APOE ε4/ε4 genotype, disclosure did not provoke elevated levels of distress. +2 more findings

• Genetics
• Health Equity

Full summary, score breakdown and related studies → Original source

Amyloid Imaging and APOE Genotype Disclosure and Short-Term Psychological Distress

63/100 ✓ Peer-reviewed Genetics JAMA Network Open

Key finding: Among 3414 included individuals, the mean (SD) age was 68.8 (6.0) years and 2116 (62%) were female. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Burnout severity in residential dementia care: individual demands and institutional-level variation in a Hungarian cross-sectional study

43/100 ✓ Peer-reviewed Risk factors BMC Nursing

Key finding: Caregiving difficulties showed excellent reliability (α = 0.928) and yielded three components explaining 73.19% of variance. +4 more findings

Full summary, score breakdown and related studies → Original source

Shared Commitment and Distinct Innovations in Dementia Policy Development and Implementation in China, Japan, and South Korea

29/100 ✓ Peer-reviewed Risk factors Asia-Pacific Psychiatry

Key finding: In conclusion, while differing in healthcare infrastructure, China, Japan, and South Korea converge in anchoring dementia care within the community.

Full summary, score breakdown and related studies → Original source

Amyloid-related imaging abnormalities (ARIA) in Alzheimer's disease: from pathophysiology to individualized risk assessment

47/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy

Key finding: While amyloid-targeting therapies mitigate the progression of cognitive decline in early-stage Alzheimer’s disease, they are associated with amyloid-related imaging abnormalities (ARIA), an imaging phenomenon presenting as cerebral edema/effusion and/or hemorrhage.

• Side Effects
• Treatments
• Brain Scans

Full summary, score breakdown and related studies → Original source

Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associated with increased risk of clinical progression in early Alzheimer's disease

51/100 ✓ Peer-reviewed Inflammation and the immune system The journal of prevention of Alzheimer's disease

Key finding: Early and accurate detection of Alzheimer's disease (AD) is essential for timely intervention and development of disease-modifying treatments.

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Physiological, Histological, and Cognitive Characterization of a Rhesus Macaque Model of Presbycusis

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: This study characterizes ARHL in a rhesus macaque model by combining histological, physiological, and cognitive assessments. +4 more findings

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Estimating the need for palliative care services in Australia by 2042

36/100 ✓ Peer-reviewed End-of-life care BMC Palliative Care

Key finding: The two methods demonstrated a growing need for palliative care in the observed and projected period. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Experiences and coping strategies of community-dwelling middle-aged and older adults with physio-cognitive decline syndrome: A qualitative study

36/100 ✓ Peer-reviewed Prevention trials Geriatric Nursing

Key finding: Participant experiences and perceptions formed three themes: (1) aging accelerates PCDS progression, (2) PCDS threatening daily life, and (3) adapting to changes. +4 more findings

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Effects of a Mediterranean Diet-Based Program on Cognitive Decline: Non-Blinded Non-Randomized Controlled Trial of the CESPORT Program

42/100 ✓ Peer-reviewed Prevention trials Nutrients

Key finding: After adjusting for baseline scores via ANCOVA, the experimental group demonstrated significantly higher post-intervention outcomes compared to the control group (p < 0.001). +4 more findings

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Algoritmo de Forrajeo de Bacterias para el Alineamiento Múltiple de Secuencias Relacionadas con Alzheimer

26/100 ✓ Peer-reviewed Risk genes beyond APOE Arandu-UTIC.

Key finding: Finalmente, en el set C, bactAtp comienza con un valor de fitness mucho más alto (3239.54) que bactOf (492.07). +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source