Newest studies

Belgian recommendations for tissue diagnosis of amyloidosis

38/100 ✓ Peer-reviewed Risk genes beyond APOE Acta Clinica Belgica

Key finding: Key recommendations emphasize that tissue biopsies remain essential for amyloidosis diagnosis and typing. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Advance care planning for people with dementia

29/100 ✓ Peer-reviewed End-of-life care Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics

Key finding: 認知症を有する人のためのアドバンス・ケア・プランニング（ACP）では，意思決定能力の揺らぎを前提に，「過去」の意思と「現在」の意向を統合し，非言語的サインも含めて本人の推定意思をくみ取ることが重要である．家族を本人の想いを伝える代弁者として位置づけ，その心理的負担を医療・ケアチームが支える必要がある．また，関係依存性自律を踏まえ，多職種協働で本人中心の対話を継続することが求められる．さらに，想いのかけらを情報通信技術（ICT）等で共有し，ACPを組織的に実施する体制整備が重要である．

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Large-Screen Group Digital Reminiscence Therapy Reduces BPSD in Dementia: Findings from a Crossover Comparative Study

32/100 ✓ Peer-reviewed Cognitive tests and assessment Clinical Gerontologist

Key finding: Compared with conventional activities, GDRT resulted in significantly greater reductions in overall BPSD (r = 0.56, p = .001) and caregiver burden (r = 0.44, p = .011). +2 more findings

• Treatments
• Digital Tools

Full summary, score breakdown and related studies → Original source

Review on Alzheimer-Suppressing Potential of different Medicinal plant

25/100 ✓ Peer-reviewed Treatments Research Journal of Science and Technology

Key finding: C. longa (Curcumin) has strong anti-amyloid, anti-inflammatory, and metal-chelating properties, offering protection against plaque formation and neuronal toxicity. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Brain PET in the era of anti-amyloid-β antibody therapy for Alzheimer disease

36/100 ✓ Peer-reviewed Biomarkers Japanese Journal of Radiology

Key finding: Tau PET reflects neurofibrillary pathology and correlates with disease severity and progression, with increasing relevance for patient stratification. +4 more findings

• Treatments
• Brain Scans

Full summary, score breakdown and related studies → Original source

Stage of Disease Among Hospitalized Persons Living With Dementia: A Multisite Study

45/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

Key finding: Among 6303 hospitalized patients with ADRD, 39.3% had mild dementia, 57.8% moderate, and 2.9% severe. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Neurodegeneration in Alzheimer’s Disease: Integrating Mechanism with Translational Therapeutic Strategies

27/100 ✓ Peer-reviewed Treatments Current Journal of Applied Science and Technology

Key finding: The amyloid cascade proposal suggests that when there is an anomaly in the handling of amyloid precursor protein, it will cause aggregation of Aß, which will culminate into the development of toxic oligomers and as well as extracellular plaques, and the eventual destruction of neurons. +1 more finding

• Treatments
• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Causality relationship between 91 inflammatory factors and Alzheimer disease: A bidirectional Mendelian randomization study

32/100 ✓ Peer-reviewed Genetics Medicine

Key finding: The MR analysis results identified 9 potential systemic inflammatory regulatory factors: C-X-C motif chemokine 5, interleukin-18 receptor 1, interleukin-6, and tumor necrosis factor, which were associated with an increased risk. +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Legacy neuropsychiatric benefit after semaglutide is linked to maximum achieved dose and independent of the maximum weight lost

16/100 ⚠ Preprint — not yet peer-reviewed Drug development medRxiv

Key finding: In propensity-matched comparator analyses, during the 2 year time-period from treatment initiation, semaglutide was associated with broadly lower neuropsychiatric event risk than metformin, SGLT2 inhibitors, and DPP-4 inhibitors. +3 more findings

• Treatments

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Implementation and service impact of anti-amyloid therapy in a psychiatry-led dementia care program: Real-world evidence from a Japanese regional dementia center

35/100 ✓ Peer-reviewed Health systems and care delivery General hospital psychiatry

Key finding: Amyloid-targeting antibody therapies for Alzheimer's disease require substantial diagnostic infrastructure including amyloid PET imaging, repeated MRI monitoring, and specialized clinical evaluation. +1 more finding

• Treatments
• Brain Scans
• Policy

Full summary, score breakdown and related studies → Original source

Impact of Postlabeling Delay on Arterial Spin-Labeling MRI-Based Measures of Cerebral Blood Flow in a Simultaneous PET/MRI Study of Aging

49/100 ✓ Peer-reviewed Brain scans and imaging American Journal of Neuroradiology

Key finding: O]water PET were strongest for 1800 msec single-PLD and generally decreased with longer PLDs, except the occipital lobe, where all PLDs showed poor agreement. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Anti-Amyloid Monoclonal Antibodies and Amyloid-Related Imaging Abnormalities in Early Alzheimer Disease

50/100 ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

Key finding: Lecanemab reduced clinical decline by roughly 27% over placebo, with ARIA-E in 12.6% of treated patients;donanemab slowed decline by about 35%, with ARIA-E near 24%. +3 more findings

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

Anti-Amyloid Monoclonal Antibodies and Amyloid-Related Imaging Abnormalities in Early Alzheimer Disease

36/100 ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

Key finding: Lecanemab reduced clinical decline by roughly 27% over placebo, with ARIA-E in 12.6% of treated patients;donanemab slowed decline by about 35%, with ARIA-E near 24%. +3 more findings

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

Routine implementation of α-synuclein Seed Amplification Assays reveals high diagnostic performance and the limited value of Alzheimer disease fluid biomarkers for detecting α-synuclein co-pathology

16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv

Key finding: In neurodegenerative diseases, the diagnostic value of α-synuclein seed amplification assay (αSAA) in routine clinical practice and its relationship with cognitive performance and fluid biomarkers remains incompletely characterized. +3 more findings

• Biomarkers
• Diagnosis

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Plasma biomarker trajectories across Alzheimer's clinical onset: a 17-year prospective study

68/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: In participants who progressed to amyloid-positive MCI, plasma p-tau181/Aβ42 and GFAP diverged from stable controls earliest (about 13 and 12 years before symptom onset, respectively), followed by Aβ42/Aβ40, p-tau181, and NfL, all of which became abnormal before symptom onset. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Identifying delirium in older adults presenting to a primary care out-of-hours (OOH) service: a retrospective cohort study

40/100 ✓ Peer-reviewed Clinical safety Age and Ageing

Key finding: Of 4288 consultations with patients ≥65 years in the study periods, 402 (9.4%) involved possible or probable delirium. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Microglial Plasticity in Vascular Dementia: Mechanisms and Therapeutic Reprogramming

39/100 ✓ Peer-reviewed Disease mechanisms International Journal of Molecular Sciences

Key finding: Emerging evidence suggests that multiple molecular pathways, including purinergic receptors, Toll-like receptors and inflammasome cascades, complement-mediated synaptic pruning, and homeostatic and metabolic regulators, such as TREM2 (triggering receptor expressed on myeloid cells 2) and CSF1R (colony-stimulating factor 1 receptor), govern microglial functional transitions.

• Brain Biology
• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

The Relationship Between Sleep, Cognition, and Dementia Risk in People With Focal Epilepsy

56/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: Optimal sleep modified both cognitive performance and dementia risk in individuals with focal epilepsy compared with stroke patients and healthy controls. +1 more finding

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Research Proposal Consciousness Mode Alzheimers

28/100 ✓ Peer-reviewed Biomarkers Zenodo (CERN European Organization for Nuclear Research)

Key finding: The dominant research paradigm for Alzheimer's disease has focused on amyloid-beta plaqueremoval for over three decades, producing no curative therapy despite billions of dollars ofinvestment. +1 more finding

• Biomarkers
• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Research Proposal Consciousness Mode Alzheimers

41/100 ✓ Peer-reviewed Biomarkers Zenodo (CERN European Organization for Nuclear Research)

Key finding: The dominant research paradigm for Alzheimer's disease has focused on amyloid-beta plaqueremoval for over three decades, producing no curative therapy despite billions of dollars ofinvestment. +1 more finding

• Biomarkers
• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Epigenetically constrained astrocyte states underlie prefrontal cortex vulnerability in Down syndrome–associated Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

Key finding: Together, these findings define a previously unrecognized astrocyte state marked by epigenetic constraint and diminished responsiveness to stress and inflammatory signals, distinguishing it from classical reactive astrocyte phenotypes. +1 more finding

• Down Syndrome
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Advances in the drug treatment of Alzheimer's disease: pathophysiology and mechanisms of action

43/100 ✓ Peer-reviewed Health systems and care delivery BMJ (Clinical research ed.)

Key finding: The mechanisms underlying continued cognitive decline after Aβ clearance remain unclear and might be independent of amyloid pathology. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

The Impact of Dementia Caregiving on the Health of the Spousal Caregiver

35/100 ✓ Peer-reviewed Clinical safety Medicina

Key finding: Evidence suggests that chronic caregiving stress contributes to biological changes such as immune dysregulation, inflammation, acceleration, aging, and potential cognitive decline in caregivers themselves.

• Caregiving

Full summary, score breakdown and related studies → Original source

Association of the Mediterranean Diet With White Matter Integrity Among Hispanic or Latino Adults

52/100 ✓ Peer-reviewed Prevention trials Neurology

Key finding: A total of 2,642 participants with a mean age of 64.3 years (95% CI 63.4-65.1, 44% male) were included. +4 more findings

• Lifestyle
• Health Equity

Full summary, score breakdown and related studies → Original source

Blood Phosphorylated Tau for the Diagnosis of Alzheimer Disease

30/100 ✓ Peer-reviewed Brain scans and imaging Clinical Chemistry

Key finding: Due to limited access to PET imaging and the reluctance of some patients to undergo lumbar puncture, the recent emergence of blood-based biomarkers (BBMs) has garnered significant interest as a lower-cost and highly accessible alternative for identifying biological evidence of disease. +1 more finding

• Brain Scans
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source