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Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic
Colin Groot, Ismael L. Calandri, Ilse Bader, Diana I. Bocancea, Hannah de Bruin, Maria Carrigan, Lyduine Eisa Collij, Flora Hillegonde Duits et al.. Neurology, 2026-04-16
Topic: Brain proteins, microglia and lab models
< 0.01). Using an operationalization of clinical criteria for LATE, 8.2% of participants with MCI or dementia from our tertiary memory clinic were classified as Possible-LATE, Probable-LATE, or LATE-AD. Probable-LATE was characterized by a milder disease course than AD, whereas LATE-AD was characterized by a more aggressive disease course. This underscores the value of the proposed clinical criteria in identifying individuals with suspected LATE, who have distinct clinical trajectories from AD. Our findings, therefore, support the use of these criteria to improve diagnostic and prognostic accuracy in the memory clinic.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Groot, C., Calandri, I. L., Bader, I., Bocancea, D. I., de Bruin, H., Carrigan, M., et al. (2026). Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic. Neurology. https://doi.org/10.1212/wnl.0000000000214810
Vancouver
Groot C, Calandri IL, Bader I, Bocancea DI, de Bruin H, Carrigan M, et al. Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic. Neurology. 2026. doi:10.1212/wnl.0000000000214810. PMID: 41990307.
BibTeX
@article{groot2026-41990307,
author = {Groot, Colin and Calandri, Ismael L. and Bader, Ilse and Bocancea, Diana I. and de Bruin, Hannah and Carrigan, Maria and Collij, Lyduine Eisa and Duits, Flora Hillegonde and others},
title = {{Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic}},
journal = {Neurology},
year = {2026},
doi = {10.1212/wnl.0000000000214810},
pmid = {41990307},
url = {https://doi.org/10.1212/wnl.0000000000214810}
}
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Key findings
- Using an operationalization of clinical criteria for LATE, 8.2% of participants with MCI or dementia from our tertiary memory clinic were classified as Possible-LATE, Probable-LATE, or LATE-AD.
- Probable-LATE was characterized by a milder disease course than AD, whereas LATE-AD was characterized by a more aggressive disease course.
- This underscores the value of the proposed clinical criteria in identifying individuals with suspected LATE, who have distinct clinical trajectories from AD.
- Our findings, therefore, support the use of these criteria to improve diagnostic and prognostic accuracy in the memory clinic.
Why it matters
Using proposed clinical criteria, about 8 in 100 people at a memory clinic with mild cognitive impairment or dementia were classified as having suspected LATE, a condition related to TDP-43 protein. Those with probable LATE had a milder course than Alzheimer's disease, while those with LATE plus Alzheimer's had a more aggressive course, which may help doctors give more accurate diagnoses and prognoses.
Study details
- Study designlongitudinal study
- Effect size8.2%
- Evidence strengthModerate
How this study scored 57/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.5 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 3 / 6 | Cited 4.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Rik Ossenkoppele: h-index 84 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 14 institution(s) in 5 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41990307) |
| Free to read | 2 / 2 | Free to read |
| Total | 57 / 100 | — |
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