Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 13,676–13,700 of 27,380 studies, newest first · page 548 of 1096.
September 2018 25
-
2018-09-11
HIV Neuroinfection and Alzheimer's Disease: Similarities and Potential Links?
41/100 ✓ Peer-reviewed Disease mechanisms Frontiers in cellular neuroscience
Key finding: Environmental factors such as chemicals, stress and pathogens are now widely believed to play important roles in the onset of some brain diseases, as they are associated with neuronal impairment and acute or chronic inflammation.
Full summary, score breakdown and related studies → Original source
-
2018-09-10
Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer's disease
51/100 ✓ Peer-reviewed Long-term cohort studies Translational neurodegeneration
Key finding: Visinin-like protein-1 (VILIP-1) and chitinase-3-like protein 1 (CHI3L1 or YKL-40) in cerebrospinal fluid (CSF) are newly discovered markers indicating neuronal damage and microglial activation, respectively. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-09
Engagement and social interaction in dementia care settings. A call for occupational and social justice
46/100 ✓ Peer-reviewed Health systems and care delivery Health & social care in the community
Key finding: It examines results from a study of five residential care settings in Ireland using the ATOSE which included 73 residents with dementia and/or enduring mental health diagnoses.
Full summary, score breakdown and related studies → Original source
-
2018-09-06
The Hippocampus in Depression: More Than the Sum of Its Parts? Advanced Hippocampal Substructure Segmentation in Depression
45/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: Hippocampal involvement in MDD is confined to principal substructures only. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-06
The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
51/100 ✓ Peer-reviewed Risk genes beyond APOE Molecular neurodegeneration
Key finding: The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases the risk for late onset Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-05
Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats
39/100 ✓ Peer-reviewed Risk factors Neurobiology of aging
Key finding: RNA-seq study further demonstrated altered expression of some key sleep and circadian regulators, such as orexin/hypocretin receptor type 2 and casein kinase 1 epsilon, in the mutant rats. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-05
Machine learning identified an Alzheimer's disease-related FDG-PET pattern which is also expressed in Lewy body dementia and Parkinson's disease dementia
44/100 ✓ Peer-reviewed Digital health tools Scientific reports
Key finding: General linear model, scaled subprofile modeling and support vector machines were examined. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-05
Transcranial magnetic stimulation intervention in Alzheimer's disease: a research proposal for a randomized controlled trial
48/100 ✓ Peer-reviewed Treatments BMC research notes
Key finding: We expect to demonstrate that personalized TMS intervention has a measurable positive impact in cognition, emotion, daily living activities and brain connectivity, thus representing a potential treatment for Alzheimer's disease. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2018-09-04
Cellular Proteostasis in Neurodegeneration
39/100 ✓ Peer-reviewed Disease mechanisms Molecular neurobiology
Key finding: Incorrect protein folding and/or modifications during protein synthesis results in inactive or toxic proteins, which may overload degradation mechanisms. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2018-09-04
Risks of Major Long-Term Side Effects Associated with Androgen-Deprivation Therapy in Men with Prostate Cancer
71/100 ✓ Peer-reviewed Digital health tools Pharmacotherapy
Key finding: Data source National Cancer Institute's Surveillance, Epidemiology, and End Results Program-Medicare linked database. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-04
Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis
68/100 ✓ Peer-reviewed Prevention and risk Social psychiatry and psychiatric epidemiology
Key finding: The overall unadjusted pooled odds ratio for the progression of MCI to dementia in people with diabetes/MetS was 1.67 (95% CI 1.27-2.19); the pooled odds ratio for progression in diabetes + MCI was 1.53 (95% CI 1.20-1.97) and in people with MetS + MCI was 2.95 (95% CI 1.23-7.05). +3 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-03
PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation
63/100 ✓ Peer-reviewed Cognitive tests and assessment Annals of Internal Medicine
Scoping reviews, a type of knowledge synthesis, follow a systematic approach to map evidence on a topic and identify main concepts, theories, sources, and knowledge gaps.
Full summary, score breakdown and related studies → Original source
-
2018-09-01
The Effects of Air Pollution on the Brain: a Review of Studies Interfacing Environmental Epidemiology and Neuroimaging
69/100 ✓ Peer-reviewed Risk factors Current environmental health reports
Key finding: An emerging body of evidence has raised concern regarding the potentially harmful effects of inhaled pollutants on the central nervous system during the last decade. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2018-09-01
Death, Depression, Disability, and Dementia Associated With Self-reported Hearing Problems: A 25-Year Study
48/100 ✓ Peer-reviewed Risk factors The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: Our study confirms the strong link between hearing status and the risk of disability, dementia, and depression. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-01
Hazardous effects of chemical pesticides on human health-Cancer and other associated disorders
38/100 ✓ Peer-reviewed Genetics Environmental toxicology and pharmacology
Key finding: We have reviewed the most common diseases including cancer which are associated with pesticides.
Full summary, score breakdown and related studies → Original source
-
2018-09-01
Understanding the role of the perivascular space in cerebral small vessel disease
38/100 ✓ Peer-reviewed Vascular contributions Cardiovascular research
Key finding: Small vessel diseases (SVDs) are a group of disorders that result from pathological alteration of the small blood vessels in the brain, including the small arteries, capillaries and veins.
Full summary, score breakdown and related studies → Original source
-
2018-09-01
The Role of Nutrition in Cognitive Function and Brain Ageing in the Elderly
38/100 ✓ Peer-reviewed Prevention trials Current nutrition reports
Key finding: Recent findings Results suggest that higher adherence to a healthy dietary pattern is associated with preservation of brain structure and function as well as slower cognitive decline, with the MIND diet substantially slowing cognitive decline, over and above the MeDi and DASH diets. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2018-09-01
Molecular properties underlying regional vulnerability to Alzheimer's disease pathology
59/100 ✓ Peer-reviewed Long-term cohort studies Brain : a journal of neurology
Key finding: Here we studied molecular properties underlying these distinct regional vulnerabilities by analysing Alzheimer's disease-typical neuroimaging patterns of amyloid deposition and neurodegeneration in relation to regional gene expression profiles of the human brain. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-01
Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease
54/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology
Key finding: There were significant widespread clusters of positive correlation between levels of microglial activation and tau aggregation in both the mild cognitive impairment (amyloid-positive and amyloid-negative) and Alzheimer's disease subjects. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-01
C9orf72-mediated ALS and FTD: multiple pathways to disease
52/100 ✓ Peer-reviewed Lewy body dementia Nature reviews. Neurology
Key finding: We suggest that a combination of upstream mechanisms involving both loss and gain of function and downstream cellular pathways involving both cell-autonomous and non-cell-autonomous effects contributes to disease progression.
Full summary, score breakdown and related studies → Original source
-
2018-09-01
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
54/100 ✓ Peer-reviewed Risk factors Nature reviews. Cardiology
Key finding: Inflammageing is a risk factor for cardiovascular diseases (CVDs), and clinical trials suggest that this association is causal. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2018-09-01
Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders
71/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: In secondary analyses, the area under the curve (AUC) of [18F]flortaucipir SUVR was compared with 3 established magnetic resonance imaging measures (hippocampal volumes and AD signature and whole-brain cortical thickness), and sensitivity and specificity of [18F]flortaucipir in MCI due to AD vs non-AD neurodegenerative disorders were determined. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-01
Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study
69/100 ✓ Peer-reviewed Prevention and risk JAMA neurology
Key finding: The mean (SD) age was 73.7 (6.0) years, and the mean (SD) follow-up time was 3.7 (1.2) years. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2018-09-01
Age-related hearing loss and cognitive decline - The potential mechanisms linking the two
48/100 ✓ Peer-reviewed Prevention and risk Auris, nasus, larynx
Key finding: The amount of attention to age-related hearing loss (ARHL) has been growing, not only from the perspective of being one of the most common health conditions affecting older adults, but also from the perspective of its relation to cognition.
Full summary, score breakdown and related studies → Original source
-
2018-09-01
Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans
70/100 ✓ Peer-reviewed Prevention and risk JAMA neurology
Key finding: In this cohort study of more than 350 000 veterans, even mild TBI without LOC was associated with more than a 2-fold increase in the risk of dementia diagnosis. +2 more findings
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →