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51/100

✓ Peer-reviewed alzhub usefulness score 51 out of 100. Long-term cohort studies

Topic: Brain proteins, microglia and lab models

Background Visinin-like protein-1 (VILIP-1) and chitinase-3-like protein 1 (CHI3L1 or YKL-40) in cerebrospinal fluid (CSF) are newly discovered markers indicating neuronal damage and microglial activation, respectively. Phosphorylated tau (p-tau) reflects the neuropathology of Alzheimer's disease (AD) and is useful as diagnostic markers for AD. However, it is unknown whether these biomarkers have similar or complementary information in AD.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Zhang, H., Ng, K. P., Therriault, J., Kang, M. S., Pascoal, T. A., Rosa-Neto, P., et al. (2018). Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer's disease. Translational neurodegeneration. https://doi.org/10.1186/s40035-018-0127-7

Vancouver

Zhang H, Ng KP, Therriault J, Kang MS, Pascoal TA, Rosa-Neto P, et al. Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer's disease. Translational neurodegeneration. 2018. doi:10.1186/s40035-018-0127-7. PMID: 30311914.

BibTeX

@article{zhang2018-30311914,
  author  = {Zhang, H. and Ng, K. P. and Therriault, J. and Kang, M. S. and Pascoal, T. A. and Rosa-Neto, P. and Gauthier, S. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer's disease}},
  journal = {Translational neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s40035-018-0127-7},
  pmid    = {30311914},
  url     = {https://doi.org/10.1186/s40035-018-0127-7}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

Phosphorylated tau (p-tau) reflects the neuropathology of Alzheimer's disease (AD) and is useful as diagnostic markers for AD.
However, it is unknown whether these biomarkers have similar or complementary information in AD.
Methods We stratified 121 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database into cognitively normal (CN), stable mild cognitive impairment (sMCI), progressive MCI (pMCI), and dementia due to AD.
Analysis of covariance (ANOVA) and chi-square analyses, Spearman correlation, and logistic regression models were performed to test the demographic, associations between biomarkers, and diagnostic accuracies, respectively.

Why it matters

This study compared cerebrospinal fluid markers of neuronal damage, microglial activation, and Alzheimer's neuropathology in 121 participants grouped by cognitive status. It is a biomarker comparison study, so it does not test any treatment, cure, or prevention.

Study details

Participants121
Effect sizeAUC 0.924; AUC 0.922
Evidence strengthLow

How this study scored 51/100

Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Translational neurodegeneration)
Journal's citation record	1 / 4	Translational Neurodegeneration: journal h-index 93 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	2 / 4	121 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 55 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	5.5 citations a year over 10 year(s) since 2018
Impact for its field and year	3 / 6	Cited 5.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	1 / 4	Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Serge G. Gauthier: h-index 121 (OpenAlex, whole career)
Institution's track record	1 / 3	McGill University: institution h-index 1,373 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 4 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 30311914)
Free to read	2 / 2	Free to read
Total	51 / 100	—

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