Newest studies

Pharmacogenetic studies in Alzheimer disease

48/100 ✓ Peer-reviewed Treatments Neurologia

Key finding: Potential pharmacogenetic biomarkers for AD have been identified; however, it is still necessary to conduct further research into other populations and to identify new biomarkers. +1 more finding

• Treatments

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Shared decision-making for people living with dementia in extended care settings: a systematic review

69/100 ✓ Peer-reviewed End-of-life care BMJ open

Key finding: Evidence suggests that people living with cognitive impairment value opportunities to be involved in everyday decision-making about their care. +1 more finding

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Cognitive Decline, Dementia, Alzheimer's Disease and Presbycusis: Examination of the Possible Molecular Mechanism

41/100 ✓ Peer-reviewed Risk factors Frontiers in neuroscience

Key finding: Recent studies have shown that deposition of Aβ and hyperphosphorylation of the tau protein may cause mitochondrial dysfunction. +2 more findings

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure

43/100 ✓ Peer-reviewed TREM2 and immune genetics Genome medicine

Key finding: Alzheimer's disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. +3 more findings

• Genetics

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Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with 18F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles

57/100 ✓ Peer-reviewed Brain scans and imaging Journal of Nuclear Medicine

Key finding: 18F-MK-6240 (18F-labeled 6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine) is a highly selective, subnanomolar-affinity PET tracer for imaging neurofibrillary tangles (NFTs). +3 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Epigenetic Regulation in Neurodegenerative Diseases

38/100 ✓ Peer-reviewed Genetics Trends in neurosciences

Key finding: Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling, and histone post-translational modifications, are involved in multiple aspects of neuronal function and development. +3 more findings

• Policy

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Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model

41/100 ✓ Peer-reviewed Inflammation and the immune system Cell death & disease

Key finding: We found the presence of amyloid beta plaques, tau tangles, neurodegeneration, and astrogliosis in the retinal ganglion cell layer of 3xTg-AD mice, already at pre-symptomatic stage.

• Brain Biology
• Biomarkers

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LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study

49/100 ✓ Peer-reviewed Genetics The Lancet. Neurology

Key finding: In the initial kindred of ten affected Italian individuals (mean age of disease onset 59·8 years [SD 8·7]), we detected significant linkage of Parkinson's disease to chromosome 14 and nominated LRP10 as the disease-causing gene. +1 more finding

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Danger in the Air: Air Pollution and Cognitive Dysfunction

39/100 ✓ Peer-reviewed Risk factors American journal of Alzheimer's disease and other dementias

Key finding: Air pollution is a multifaceted toxic chemical mixture capable of assaulting the central nervous system. +3 more findings

• Risk Factors

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Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms

45/100 ✓ Peer-reviewed Disease mechanisms Molecular psychiatry

Key finding: The data suggest that LPS induces working memory dysfunction via circulating IL-1β but direct hippocampal action of IL-1β causes neuronal dysfunction and may drive neuronal death. +2 more findings

• Brain Biology

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Amyloid pathology fingerprint differentiates post-traumatic stress disorder and traumatic brain injury

39/100 ✓ Peer-reviewed Tau biomarkers NeuroImage. Clinical

Key finding: Compared to controls, all three clinical groups showed a pattern of mainly increased referenced standard uptake values (SUVR) for the amyloid tracer [18F]-AV45 PET, with rank order PTSD > TBI_PTSD > TBI > Control, and same rank order was seen in the deficits of cognitive functions. +4 more findings

• Biomarkers
• Risk Factors

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Barriers and facilitators to the access to and use of formal dementia care: findings of a focus group study with people with dementia, informal carers and health and social care professionals in eight European countries

50/100 ✓ Peer-reviewed Caregiving BMC geriatrics

Key finding: Further investigations are needed to elaborate how the concept of a key contact person could be integrated with existing case management approaches and how the independence and autonomy of people with dementia can be strengthened when formal care needs to be accessed and used.

• Caregiving

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Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

48/100 ✓ Peer-reviewed Risk genes beyond APOE Autophagy

Key finding: Although loss of presenilin 1 function has been reported to impair lysosomal function and prevent autophagy flux, the detailed mechanism leading to autophagy dysfunction in AD remains to be elucidated. +3 more findings

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Disease prediction using graph convolutional networks: Application to Autism Spectrum Disorder and Alzheimer's disease

41/100 ✓ Peer-reviewed Long-term cohort studies Medical image analysis

Key finding: This framework exploits Graph Convolutional Networks (GCNs) and involves representing populations as a sparse graph, where its nodes are associated with imaging-based feature vectors, while phenotypic information is integrated as edge weights. +1 more finding

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Insomnia and Mild Cognitive Impairment

39/100 ✓ Peer-reviewed Risk factors Gerontology & geriatric medicine

Key finding: Three different types of insomnia are recognized: sleep-onset or initial insomnia, sleep maintenance or middle insomnia, and early morning awakening or late insomnia. +4 more findings

• Early Stage
• Lifestyle

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Home-Time After Discharge Among Patients Hospitalized With Heart Failure

53/100 ✓ Peer-reviewed Digital health tools Journal of the American College of Cardiology

Key finding: Home-time, which can be readily calculated from administrative claims data, is substantially reduced for many patients following hospitalization for HF and is highly correlated with traditional time-to-event mortality and hospitalization outcomes. +2 more findings

• Care Services

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Changes of Colonic Bacterial Composition in Parkinson's Disease and Other Neurodegenerative Diseases

55/100 ✓ Peer-reviewed Disease mechanisms Nutrients

Key finding: In recent years evidence has emerged that neurodegenerative diseases (NDs) are strongly associated with the microbiome composition in the gut.

• Other Dementias

Full summary, score breakdown and related studies → Original source

The emerging risk of exposure to air pollution on cognitive decline and Alzheimer's disease - Evidence from epidemiological and animal studies

41/100 ✓ Peer-reviewed Risk factors Biomedical journal

Key finding: While its effects on cardiopulmonary morbidity and mortality have been extensively studied, growing evidence has emerged that exposure to polluted air is associated with impaired cognitive functions at all ages and increased risk of AD and other dementias in later life; this association is particularly notable with traffic related pollutants such as nitrogen dioxide, nitrous oxide, black carbon, and small diameter airborne solids and liquids known as particulate matter. +1 more finding

• Risk Factors

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Association of Excessive Daytime Sleepiness With Longitudinal β-Amyloid Accumulation in Elderly Persons Without Dementia

69/100 ✓ Peer-reviewed Prevention trials JAMA neurology

Key finding: Baseline EDS was associated with increased longitudinal Aβ accumulation in elderly persons without dementia, suggesting that those with EDS may be more vulnerable to pathologic changes associated with Alzheimer disease. +4 more findings

• Lifestyle

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Association of Clinical Outcomes With Surgical Repair of Hip Fracture vs Nonsurgical Management in Nursing Home Residents With Advanced Dementia

71/100 ✓ Peer-reviewed End-of-life care JAMA internal medicine

Key finding: Surgical repair of a hip fracture was associated with lower mortality among NH residents with advanced dementia and should be considered together with the residents' goals of care in management decisions. +1 more finding

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Diets for Health: Goals and Guidelines

38/100 ✓ Peer-reviewed Prevention trials American family physician

Key finding: Diet is the single most significant risk factor for disability and premature death.

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Cognition and dementia in older patients with epilepsy

55/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology

Key finding: In developed countries the highest incidence of epilepsy is already in people over 65 and, as life expectancy increases, individuals who developed epilepsy at a young age are also living longer. +3 more findings

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Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease

68/100 ✓ Peer-reviewed Cognitive tests and assessment Brain : a journal of neurology

Key finding: This work aimed at investigating the temporal relationship between microglial activation and clinical progression of Alzheimer's disease. +3 more findings

• Brain Biology
• Brain Scans

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A 2-Step Cerebrospinal Algorithm for the Selection of Frontotemporal Lobar Degeneration Subtypes

61/100 ✓ Peer-reviewed Tau biomarkers JAMA neurology

Key finding: Cerebrospinal fluid (CSF) core Alzheimer disease (AD) biomarkers have shown an excellent capacity for the in vivo detection of AD. +3 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response

39/100 ✓ Peer-reviewed TREM2 and immune genetics Inflammation

Key finding: Several lines of evidence suggest that TREM2 is upregulated and positively correlates with tau pathology in the brains of AD patients. +3 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source