Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,926–19,950 of 27,380 studies, newest first · page 798 of 1096.
September 2011 25
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2011-09-14
Brain amyloid imaging
42/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: Imaging of brain β-amyloid plaques with (18)F-labeled tracers for PET will likely be available in clinical practice to assist the diagnosis of Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-14
A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease
69/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Primary clinical efficacy outcomes were not significant. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-14
Chronic divalproex sodium use and brain atrophy in Alzheimer disease
72/100 ✓ Peer-reviewed Genetics Neurology
Key finding: There were no baseline differences between active treatment and placebo groups in age, education, brain volumes, clinical rating scores, or APOE ε4 carrier status. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-13
Differences in Mortality Associated with Dementia in U.S. Blacks and Whites
32/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society
Key finding: From 1999 to 2004, the U.S. age-adjusted annual death rate per 100,000 for dementia was 628 in blacks and 647 in whites. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-12
Reshaping the mind: The benefits of bilingualism
40/100 ✓ Peer-reviewed Risk factors Canadian Journal of Experimental Psychology/Revue canadienne de psychologie expérimentale
Key finding: Studies have shown that bilingual individuals consistently outperform their monolingual counterparts on tasks involving executive control.
Full summary, score breakdown and related studies → Original source
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2011-09-12
Physics strategies for sparing neural stem cells during whole-brain radiation treatments
35/100 ✓ Peer-reviewed Health systems and care delivery Medical Physics
Key finding: The plans are all normalized such that 50% of the PTV receives 30 Gy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-12
Autosomal recessive causes likely in early-onset Alzheimer disease
54/100 ✓ Peer-reviewed Brain tissue and pathology Archives of neurology
Key finding: A liability threshold model of disease was used to estimate heritability of EOAD and late-onset Alzheimer disease (AD) using concordance for AD among parent-offspring pairs. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-12
Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial
74/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: Outcome measures were analyzed using repeated-measures analysis of covariance. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-09
Large-scale brain networks and psychopathology: a unifying triple network model
36/100 ✓ Peer-reviewed Risk factors Trends in cognitive sciences
Key finding: The science of large-scale brain networks offers a powerful paradigm for investigating cognitive and affective dysfunction in psychiatric and neurological disorders. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-09
Subtypes of progressive aphasia: application of the International Consensus Criteria and validation using β-amyloid imaging
53/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: The semantic and non-fluent/agrammatic variants are largely associated with frontotemporal lobar degeneration with TDP-43 and tau pathology, respectively. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-08
Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia
48/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of biological chemistry
Key finding: Although high concentrations of Aβ (μM) can induce direct toxicity to neurons, we find that low concentration (nM) induce neuronal loss through a microglia-mediated mechanism. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-08
Transient cognitive impairment in TIA and minor stroke
49/100 ✓ Peer-reviewed Cognitive tests and assessment Stroke
Key finding: Acute cognitive impairment and delirium occur after major stroke and are associated with poor cognitive outcome. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-08
Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4
40/100 ✓ Peer-reviewed Drug development Age (Dordrecht, Netherlands)
Key finding: Several physiopathological features including hyperglycemia, oxidative stress, and dysfunctional insulin signaling relate DM to AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-07
Modeling familial Alzheimer's disease with induced pluripotent stem cells
36/100 ✓ Peer-reviewed Risk genes beyond APOE Human Molecular Genetics
Key finding: Our findings demonstrate that the FAD-iPSC-derived neuron is a valid model of AD and provides an innovative strategy for the study of age-related neurodegenerative diseases.
Full summary, score breakdown and related studies → Original source
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2011-09-07
A pathophysiological framework of hippocampal dysfunction in ageing and disease
36/100 ✓ Peer-reviewed Risk factors Nature reviews. Neuroscience
Key finding: Recent neuroimaging findings indicate that these disorders differentially target distinct subregions of the hippocampal circuit. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-07
Advanced glycation end product level, diabetes, and accelerated cognitive aging
48/100 ✓ Peer-reviewed Disease mechanisms Neurology
Key finding: High peripheral AGE level is associated with greater cognitive decline in older adults with and without diabetes. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-06
The interplay of cholinergic function, attention, and falls in Parkinson's disease
36/100 ✓ Peer-reviewed Clinical safety Movement disorders : official journal of the Movement Disorder Society
Key finding: Both these structures undergo degeneration in Parkinson's disease (PD), with more severe loss associated with cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-06
Neural language networks at birth
64/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America
Key finding: In adults and children, brain imaging studies have shown that auditory language activates a bilateral frontotemporal network with a left hemispheric dominance.
Full summary, score breakdown and related studies → Original source
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2011-09-06
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease
48/100 ✓ Peer-reviewed Getting a diagnosis Neurobiology of learning and memory
Key finding: These findings have established the oligomer hypothesis as a new molecular basis for the cause, diagnosis, and treatment of AD.
Full summary, score breakdown and related studies → Original source
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2011-09-06
Effect of second-generation antipsychotics on caregiver burden in Alzheimer's disease
59/100 ✓ Peer-reviewed Treatments The Journal of clinical psychiatry
Key finding: In AD patients with symptoms of psychosis, agitation, or aggressive behavior, medications can have a small but significant impact on caregiver burden. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-03
Parkinsonism and frontotemporal dementia: the clinical overlap
40/100 ✓ Peer-reviewed Digital health tools Journal of molecular neuroscience : MN
Key finding: Frontotemporal dementia is commonly associated with parkinsonism in several sporadic (i.e., progressive supranuclear palsy, corticobasal degeneration) and familial neurodegenerative disorders (i.e., frontotemporal dementia associated with parkinsonism and MAPT or progranulin mutations in chromosome 17).
Full summary, score breakdown and related studies → Original source
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2011-09-01
Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation
36/100 ✓ Peer-reviewed Risk factors Neuron
Key finding: NOS2 deficiency or oral treatment with the NOS2 inhibitor L-NIL strongly decreased 3NTyr(10)-Aβ, overall Aβ deposition and cognitive dysfunction in APP/PS1 mice.
Full summary, score breakdown and related studies → Original source
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2011-09-01
Purinergic signalling: from normal behaviour to pathological brain function
36/100 ✓ Peer-reviewed Risk factors Progress in neurobiology
Key finding: They mediate both fast signalling in neurotransmission and neuromodulation and long-term (trophic) signalling in cell proliferation, differentiation and death. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-01
Cholinesterases, a target of pharmacology and toxicology
36/100 ✓ Peer-reviewed Treatments Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
Key finding: The crucial role of the cholinesterases in neural transmission makes them a primary target of a large number of cholinesterase-inhibiting drugs and toxins.
Full summary, score breakdown and related studies → Original source
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2011-09-01
Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis
79/100 ✓ Peer-reviewed Vascular contributions JAMA
Key finding: Among 14 placebo-controlled trials of elderly patients with dementia reporting a total global outcome score that includes symptoms such as psychosis, mood alterations, and aggression, small but statistically significant effects sizes ranging from 0.12 and 0.20 were observed for aripiprazole, olanzapine, and risperidone. +4 more findings
Full summary, score breakdown and related studies → Original source
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