Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 13,651–13,675 of 27,380 studies, newest first · page 547 of 1096.
September 2018 25
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2018-09-21
Effects of Normative Adjustments to the Montreal Cognitive Assessment
45/100 ✓ Peer-reviewed Long-term cohort studies The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: 499 adults 48 to 91 years-old enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) and were administered the MoCA during baseline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-21
The genetic landscape of Parkinson's disease
47/100 ✓ Peer-reviewed Disparities Revue neurologique
Key finding: GBA is a major PD risk factor often associated with dementia.
Full summary, score breakdown and related studies → Original source
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2018-09-21
Nutrition and prevention of cognitive impairment
57/100 ✓ Peer-reviewed Prevention and risk The Lancet. Neurology
Key finding: For some nutrients and food groups, protection might be greater in individuals with either deficiencies in certain nutrients or a genetic predisposition to cognitive impairment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-20
Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau
45/100 ✓ Peer-reviewed Drug development Acta neuropathologica
Key finding: Clinical progression is tightly linked to the progressive spread of Tau pathology throughout the brain, and several lines of evidence suggest that Tau aggregates or "seeds" may propagate pathology by spreading from cell to cell in a "prion like" manner.
Full summary, score breakdown and related studies → Original source
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2018-09-19
Thiamine deficiency contributes to synapse and neural circuit defects
39/100 ✓ Peer-reviewed Disease mechanisms Biological research
Key finding: To demonstrate this hypothesis, we established abnormalities in the glucose metabolism utilizing thiamine deficiency in vitro and in vivo, and we found dramatically reduced dendrite spine density. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-19
Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015–2060) in adults aged ≥65 years
55/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia
These estimates can be used to guide planning and interventions related to caring for the ADRD population and supporting caregivers.
Full summary, score breakdown and related studies → Original source
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2018-09-19
Vascular risk at younger ages most strongly associates with current and future brain volume
60/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: Given the potential therapeutic effect of vascular disease control timing to reduce dementia risk, we investigated the age-related influences of vascular risk factor burden on brain structure throughout the lifespan. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-19
Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE)
66/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy
Key finding: We investigated the effect of crenezumab, a humanized anti-amyloid-beta (Aβ) immunoglobulin (Ig)G4 monoclonal antibody, on biomarkers of amyloid pathology, neurodegeneration, and disease progression in patients with mild-to-moderate Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-19
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
53/100 ✓ Peer-reviewed TREM2 and immune genetics Proceedings of the National Academy of Sciences of the United States of America
Key finding: Hemizygous missense variants in Triggering Receptor Expressed on Myeloid Cells 2 ( TREM2 ) are associated with elevated risk for developing late-onset AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-19
Progress and future challenges in aging and diversity research in the United States
50/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This report disseminates the research priorities that emerged from this conference, building on an earlier Gerontological Society of America preconference. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-17
Understanding the Role of ApoE Fragments in Alzheimer's Disease
39/100 ✓ Peer-reviewed Genetics Neurochemical research
Key finding: It has been known for decades that the APOE ɛ4 allele is the most significant genetic risk factor for late-onset AD and yet its precise role in the disease remains unclear. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-16
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly
79/100 ✓ Peer-reviewed How common it is The New England journal of medicine
Key finding: Higher all-cause mortality was observed among apparently healthy older adults who received daily aspirin than among those who received placebo and was attributed primarily to cancer-related death. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-16
The “American (cancer) patients first” plan to reduce drug prices—A critical assessment
36/100 ✓ Peer-reviewed Health systems and care delivery American Journal of Hematology
Key finding: Serious concerns over the rising cost of cancer drugs in the United States1-3 are increasing,4-9 following a decade during which prices rose from an average of less than $10 000/year to more than $170 000/year in 2017.10 Despite the drug industry's wish to be “part of the solution,” the problem continues to worsen.6 Between 1995 and 2013, the launch price of cancer drugs increased by 10%-12% every year.11 According to a March 2018 report, the Average Wholesale Prices of drugs increased at unprecedented rates.12 A study by Gordon and colleagues showed a 25% average annual price increase of drugs already on the market, despite competition.13 Cancer drugs spending doubled since 2013 and is expected to double again by 2022.14 This suggests that health care is different from other industries where traditional free market forces are effective in lowering prices, and that other measures are needed. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-16
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly
81/100 ✓ Peer-reviewed Prevention and risk The New England journal of medicine
Key finding: After a median of 4.7 years of follow-up, the rate of cardiovascular disease was 10.7 events per 1000 person-years in the aspirin group and 11.3 events per 1000 person-years in the placebo group (hazard ratio, 0.95; 95% confidence interval [CI], 0.83 to 1.08). +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-15
Technology-based cognitive training and rehabilitation interventions for individuals with mild cognitive impairment: a systematic review
69/100 ✓ Peer-reviewed Prevention trials BMC geriatrics
Key finding: Technology-based cognitive training and rehabilitation interventions show promise, but the findings were inconsistent due to the variations in study design. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-09-14
Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease
55/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: These longitudinal estimates clarify the sequence and temporal dynamics of presymptomatic pathologic changes in autosomal dominant AD, information critical to a better understanding of the disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-14
An MRI measure of degenerative and cerebrovascular pathology in Alzheimer disease
61/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: We developed, replicated, and validated an MRI measure of cerebrovascular and neurodegenerative pathologies that are associated with clinical and neuropathologic diagnosis of AD and related to established biomarkers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-12
Alzheimer's Disease and Rheumatoid Arthritis: A Mendelian Randomization Study
80/100 ✓ Peer-reviewed Genetics Frontiers in neuroscience
Key finding: Until now, it is still unclear that AD is a causally associated with RA. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-09-12
Joint Classification and Regression via Deep Multi-Task Multi-Channel Learning for Alzheimer's Disease Diagnosis
48/100 ✓ Peer-reviewed Digital health tools IEEE transactions on bio-medical engineering
Key finding: We evaluate the proposed method on four large multi-center cohorts with 1984 subjects, and the experimental results demonstrate that DM 2L is superior to several state-of-the-art joint learning methods in both the tasks of disease classification and clinical score regression.
Full summary, score breakdown and related studies → Original source
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2018-09-12
Perceived barriers and facilitators in providing palliative care for people with severe dementia: the healthcare professionals' experiences
41/100 ✓ Peer-reviewed End-of-life care BMC health services research
Key finding: The findings indicate that healthcare professionals experienced several structural barriers that prevented the provision of palliative care to people with severe dementia in long-term care facilities. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-09-12
Increased cerebral microbleeds and cortical superficial siderosis in pediatric patients with Down syndrome
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Key finding: In vivo MRI biomarkers can support the diagnosis of early-onset cerebral amyloid angiopathy, which might already be present in pediatric Down syndrome patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-09-12
Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults: A Longitudinal Study from the Multidomain Alzheimer Prevention Trial
61/100 ✓ Peer-reviewed Treatments Journal of the American Geriatrics Society
Key finding: One hundred two (37.9%) participants were amyloid positive. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-12
Serum neurofilament light chain in behavioral variant frontotemporal dementia
54/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: As serum NfL correlates with functional impairment and brain atrophy in bvFTD at different disease stages, we propose it as marker of disease severity, paving the way for its future use as outcome measure for clinical trials.
Full summary, score breakdown and related studies → Original source
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2018-09-11
Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
71/100 ✓ Peer-reviewed Risk factors BMJ open
Key finding: We have found evidence of a positive association between residential levels of air pollution across London and being diagnosed with dementia, which is unexplained by known confounding factors. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-09-11
The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease
57/100 ✓ Peer-reviewed Genetics Scientific data
Key finding: Genetic and genome-wide association studies (GWAS) have identified about 33 risk factor genes for common, late-onset AD (LOAD), but these risk loci fail to account for the majority of affected cases and can neither provide clinically meaningful prediction of development of AD nor offer actionable mechanisms. +4 more findings
Full summary, score breakdown and related studies → Original source
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