Newest studies

Absolute 10-year risk of dementia by age, sex and APOE genotype: a population-based cohort study

49/100 ✓ Peer-reviewed Genetics CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Key finding: Among 104 537 individuals, the absolute 10-year risk of Alzheimer disease in 3017 women and men who were carriers of the APOE ɛ44 genotype was, respectively, 7% and 6% at age 60-69 years, 16% and 12% at age 70-79 years, and 24% and 19% at age 80 years and older.

• Genetics
• Risk Factors

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Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports

53/100 ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology

Key finding: Traumatic brain injury has been associated with increased risk of Parkinson disease and parkinsonism, and parkinsonism and Lewy body disease (LBD) can occur with chronic traumatic encephalopathy (CTE). +2 more findings

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Association of Amyloid Positron Emission Tomography With Changes in Diagnosis and Patient Treatment in an Unselected Memory Clinic Cohort: The ABIDE Project

58/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: Amyloid PET results were positive for 242 patients (48%). +3 more findings

• Brain Scans
• Treatments
• Diagnosis

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Understanding the impact of sex and gender in Alzheimer's disease: A call to action

39/100 ✓ Peer-reviewed How common it is Alzheimer's & Dementia

Key finding: The panel concluded that exclusion of sex and gender considerations has impeded faster progress in detecting, treating, and caring for Alzheimer's disease +3 more findings

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Modeling amyloid beta and tau pathology in human cerebral organoids

41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular psychiatry

Key finding: Analysis of COs by histological and biochemical methods revealed that organoids produced from iPSCs derived from patients affected by familial AD or Down syndrome (DS) spontaneously develop over time pathological features of AD, including accumulation of structures highly reminiscent to amyloid plaques and neurofibrillary tangles. +2 more findings

• Brain Biology

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Neurofilaments as biomarkers in neurological disorders

58/100 ✓ Peer-reviewed Biomarkers Nature Reviews Neurology

Key finding: Neurofilament proteins have promise in this context because their levels rise upon neuroaxonal damage not only in the cerebrospinal fluid (CSF) but also in blood, and they indicate neuroaxonal injury independent of causal pathways. +1 more finding

• Biomarkers

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Stroke and dementia risk: A systematic review and meta-analysis

70/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Stroke is a strong, independent, and potentially modifiable risk factor for all-cause dementia. +1 more finding

• Risk Factors

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REM sleep behaviour disorder

53/100 ✓ Peer-reviewed Getting a diagnosis Nature reviews. Disease primers

Key finding: RBD is categorized as either idiopathic RBD or symptomatic (also known as secondary) RBD; the latter is associated with antidepressant use or with neurological diseases, especially α-synucleinopathies (such as Parkinson disease, dementia with Lewy bodies and multiple system atrophy) but also narcolepsy type 1.

• Other Dementias
• Lifestyle

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Multicrossover Randomized Controlled Trial Designs in Alzheimer Disease

52/100 ✓ Peer-reviewed Clinical trials Annals of neurology

Key finding: Heterogeneities are inherently controlled and the sensitivity, specificity and clinical relevance of outcomes can be enhanced further by including personalized outcome measures for each individual. +4 more findings

• Clinical Trials
• Treatments

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Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

69/100 ✓ Peer-reviewed Disease mechanisms Clinical interventions in aging

Key finding: Recent studies have demonstrated that gut microbiota may be involved in frailty physiopathology by promoting chronic inflammation and anabolic resistance. +3 more findings

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Soluble TREM2 changes during the clinical course of Alzheimer's disease: A meta-analysis

63/100 ✓ Peer-reviewed TREM2 and immune genetics Neuroscience letters

Key finding: However, previous studies evaluating levels of sTREM2 in different clinical stages of AD have yielded inconsistent results. +3 more findings

• Genetics
• Early Stage

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Structures of filaments from Pick's disease reveal a novel tau protein fold

61/100 ✓ Peer-reviewed Lewy body dementia Nature

Key finding: Tau filaments have distinct cellular and neuroanatomical distributions 5 , with morphological and biochemical differences suggesting that they may be able to adopt disease-specific molecular conformations 6,7 . +1 more finding

• Brain Biology

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Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

64/100 ✓ Peer-reviewed Biomarkers The Lancet. Neurology

Key finding: The diagnostic performance of plasma biomarkers was poor (area under the curve [AUC] between 0·53 [95% CI 0·44-0·62] and 0·74 [0·66-0·82]) except for plasma NfL concentrations, which had an AUC of 0·88 (0·82-0·93) for the differentiation of the asymptomatic group versus the prodromal Alzheimer's disease group and 0·95 (0·92-0·98) for the asymptomatic group versus the Alzheimer's disease dementia group. +3 more findings

• Biomarkers
• Diagnosis
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Sarcopenia and Muscle Functions at Various Stages of Alzheimer Disease

47/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in neurology

Key finding: This study aimed to investigate the prevalence of sarcopenia, factors associated with sarcopenia in elderly subjects with AD, and differences in muscle functions of the upper and lower extremities and gait speed at various stages of AD. +3 more findings

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Rapid and in situ optical detection of trace lithium in tissues

39/100 ✓ Peer-reviewed Drug development Biomedical optics express

Key finding: Thyroid lithium intensity increases while iodine intensity decreases. +4 more findings

• Treatments

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Sustainable method for Alzheimer dementia prediction in mild cognitive impairment: Electroencephalographic connectivity and graph theory combined with apolipoprotein E

54/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology

Key finding: Concluding, this innovative EEG analysis, in combination with a genetic test (both low-cost and widely available), could evaluate on an individual basis with great precision the risk of MCI progression. +2 more findings

• Early Stage
• Genetics

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Too sweet: Problems of protein glycation in the eye

39/100 ✓ Peer-reviewed Brain scans and imaging Experimental eye research

Key finding: Laboratory and epidemiological data indicate that high blood sugar levels and/or consuming high glycemia diets are linked to multiple age-related diseases, including age-related macular degeneration, cataract, Parkinson's disease, Alzheimer's disease, diabetic retinopathy, and, apparently glaucoma. +1 more finding

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Postoperative delirium

41/100 ✓ Peer-reviewed Clinical safety Korean journal of anesthesiology

Key finding: Delirium can be defined as an 'acute brain dysfunction.' +1 more finding

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APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

61/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Our results indicate that APOE ε4 is independently associated with a greater severity of LB pathology. +4 more findings

• Genetics
• Other Dementias

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Integrated Memory Care Clinic: Design, Implementation, and Initial Results

41/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: We observed nonsignificant improvements in neuropsychiatric symptom severity (p=.07), caregiver distress (p=.69), and caregiver competence (p=.18).

• Diagnosis
• Caregiving

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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

54/100 ✓ Peer-reviewed Risk factors Cell

Key finding: Here, we investigate how partial loss of function of TBK1, a major genetic cause for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) comorbidity, leads to age-dependent neurodegeneration. +4 more findings

• Brain Biology

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Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice

39/100 ✓ Peer-reviewed Drug development Acta neuropathologica communications

Key finding: Passive immunization experiments using intra-peritoneal injections have previously shown that MC1 is effective at reducing tau pathology in the forebrain of tau transgenic JNPL3 mice. +1 more finding

• Brain Biology

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Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer Disease

39/100 ✓ Peer-reviewed Costs and economics Clinics in geriatric medicine

Key finding: Traumatic brain injury (TBI) is a major health and economic burden. +4 more findings

• Risk Factors

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Cognitive Reserve Relates to Functional Network Efficiency in Alzheimer's Disease

39/100 ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience

Key finding: In this context, the cognitive reserve (CR) hypothesis has been proposed to explain the discontinuity between pathophysiological and clinical expression of AD, suggesting that CR mitigates the effects of pathology on clinical expression and cognition. fMRI studies of the human connectome have recently reported that AD patients present diminished functional efficiency in resting-state networks, leading to a loss in information flow and cognitive processing. +1 more finding

• Biomarkers

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An Overview of Cognitive Impairment

38/100 ✓ Peer-reviewed Prevention trials Clinics in geriatric medicine

Key finding: Eventually, this can result in mild cognitive impairment and dementia.

• Lifestyle

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