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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 14,301–14,325 of 27,380 studies, newest first · page 573 of 1096.

January 2018 25

  1. 2018-01-30

    Autophagy and Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Implications

    ✓ Peer-reviewed Inflammation and the immune system Frontiers in aging neuroscience

    Key finding: It is characterized by a progressive and irreversible loss of cognitive abilities and formation of senile plaques, composed mainly of amyloid β (Aβ), and neurofibrillary tangles (NFTs), composed of tau protein, in the hippocampus and cortex of afflicted humans. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2018-01-29

    Cohort Profile Update: The Lothian Birth Cohorts of 1921 and 1936

    ✓ Peer-reviewed Genetics International Journal of Epidemiology

    Key finding: By wave, compared with those who remained in the LBC1921 study at Waves 1 to 5, participants who dropped out had: significantly lower older-age IQ scores at Wave 1 Wave 2 = and Wave 3 = lower scores at Waves and at Waves 1 = and 2 = By wave, compared with those who remained in the LBC1936 study at Waves 1 to participants who dropped out had: significantly lower older-age IQ scores at Wave 1 Wave 2 = and Wave 3 = lower scores at Wave 1 = Wave 2 and Wave 3 = lower at Wave 1 = Wave 2 = and Wave 3 and lower physical as at Wave 1 Wave 2 = and Wave 3 = and at Wave 1 = at each wave in the Lothian Birth Cohort 1921 are mean and standard for and for each wave sample = Wave 1 = Waves 1 and 2 = Waves 2 and 3 = Waves IQ from Moray House Test for age in at time of testing and to IQ is the was from to from the in 1 and at Wave 1. as of from the Wave 2 two participants who not Wave 1.

    Full summary, score breakdown and related studies → Original source

  3. 2018-01-29

    Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

    ✓ Peer-reviewed Risk factors Nature reviews. Neurology

    Key finding: Insulin resistance is a core feature of T2DM and is emerging as a potentially important feature of ADRDs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2018-01-29

    Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis

    ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: AAV-mediated progranulin delivery reduced lipofuscinosis in Grn -/- mice even after the onset of pathology. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2018-01-29

    Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

    ✓ Peer-reviewed Brain scans and imaging Nature reviews. Neurology

    Key finding: BBB disruption allows influx into the brain of neurotoxic blood-derived debris, cells and microbial pathogens and is associated with inflammatory and immune responses, which can initiate multiple pathways of neurodegeneration.

    Full summary, score breakdown and related studies → Original source

  6. 2018-01-26

    Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice

    ✓ Peer-reviewed Biomarkers Journal of neurochemistry

    Key finding: The Wnt signaling pathway has several key functions in the adult brain and has been associated with AD, mainly as a neuroprotective factor against Aβ toxicity and tau phosphorylation. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2018-01-25

    Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

    ✓ Peer-reviewed Brain scans and imaging PLoS medicine

    Key finding: We found that distinct sphingolipid species including sphingomyelin (SM) with acyl residue sums C16:0, C18:1, and C16:1 (SM C16:0, SM C18:1, SM C16:1) and hydroxysphingomyelin with acyl residue sum C14:1 (SM (OH) C14:1) were consistently associated with severity of AD pathology at autopsy and AD progression across prodromal and preclinical stages. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2018-01-24

    Can Exercise Improve Cognitive Symptoms of Alzheimer's Disease?

    ✓ Peer-reviewed Prevention trials Journal of the American Geriatrics Society

    Key finding: Exercise interventions were performed 3.4 ± 1.4 days per week at moderate intensity (3.7 ± 0.6 metabolic equivalents) for 45.2 ± 17.0 minutes per session for 18.6 ± 10.0 weeks and consisted primarily of aerobic exercise (65%). +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2018-01-24

    Differences in do-not-resuscitate orders, hospice care utilization, and late referral to hospice care between cancer and non-cancer decedents in a tertiary Hospital in Taiwan between 2010 and 2015: a hospital-based observational study

    ✓ Peer-reviewed End-of-life care BMC palliative care

    Key finding: Further guidelines should be developed to help clinicians to promptly refer terminal cancer and non-cancer patients to hospice care. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2018-01-23

    A new enzyme-linked immunosorbent assay for neurofilament light in cerebrospinal fluid: analytical validation and clinical evaluation

    ✓ Peer-reviewed Biomarkers Alzheimer s Research & Therapy

    Key finding: Our new NfL ELISA showed a good analytical performance (inter-plate coefficient of variation (CV) < 13%), with no cross-reactivity with neurofilament medium and heavy (NfM and NfH). +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2018-01-23

    Vision in Alzheimer's disease: a focus on the anterior afferent pathway

    ✓ Peer-reviewed Brain scans and imaging Neurodegenerative disease management

    Key finding: However, investigations have revealed findings within the anterior (i.e., pregeniculate) afferent visual pathways that rely on retinal imaging and electrophysiologic methodologies for detection.

    Full summary, score breakdown and related studies → Original source

  12. 2018-01-23

    An update on diagnostic and prognostic biomarkers for traumatic brain injury

    ✓ Peer-reviewed Biomarkers Expert review of molecular diagnostics

    Key finding: Traumatic brain injury (TBI) is a major worldwide neurological disorder of epidemic proportions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2018-01-22

    Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks

    ✓ Peer-reviewed Risk genes beyond APOE Scientific reports

    Key finding: Its enzymatic activity results in secretion of a neuroprotective APP cleavage product (sAPP-alpha) and prevents formation of the amyloidogenic A-beta peptides, major hallmarks of Alzheimer's disease (AD). +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2018-01-22

    Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes

    ✓ Peer-reviewed TREM2 and immune genetics International journal of molecular sciences

    Key finding: As the innate immune effector of the brain, microglia are involved in several functions: regulation of inflammation, synaptic connectivity, programmed cell death, wiring and circuitry formation, phagocytosis of cell debris, and synaptic pruning and sculpting of postnatal neural circuits. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2018-01-19

    Compulsive sexual behaviour disorder in the ICD‐11

    ✓ Peer-reviewed Risk factors World Psychiatry

    Key finding: The pattern is manifested in one or more of the following: a) engaging in repetitive sexual activities has become a central focus of the person's life to the point of neglecting health and personal care or other interests, activities and responsibilities; b) the person has made numerous unsuccessful efforts to control or significantly reduce repetitive sexual behaviour; c) the person continues to engage in repetitive sexual behaviour despite adverse consequences (e.g., repeated relationship disruption, occupational consequences, negative impact on health); or d) the person continues to engage in repetitive sexual behaviour even when he/she derives little or no satisfaction from it. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2018-01-19

    Long-term exposure to residential green and blue spaces and anxiety and depression in adults: A cross-sectional study

    ✓ Peer-reviewed Prevention trials Environmental research

    Key finding: Our findings suggest a potential protective role of green spaces on mental health (depression and anxiety) in adults, but further studies, especially longitudinal studies, are needed to provide further evidence of these benefits and of the mediation role of exposures like air pollution and noise. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2018-01-19

    Autoimmune glial fibrillary acidic protein astrocytopathy in Chinese patients: a retrospective study

    ✓ Peer-reviewed Biomarkers European journal of neurology

    Key finding: The present patients with positive GFAP-immunoglobulin G are highly similar to autoimmune GFAP astrocytopathy, described in a recent report. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2018-01-19

    Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus

    ✓ Peer-reviewed Hippocampus size on brain scans Nature communications

    Key finding: The hippocampal dentate gyrus (DG) is a major site for experience-dependent plasticity associated with sustained transcriptional alterations, potentially mediated by epigenetic modifications. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2018-01-19

    Effect of the replacement of dietary vegetable oils with a low dose of extravirgin olive oil in the Mediterranean Diet on cognitive functions in the elderly

    ✓ Peer-reviewed Prevention trials Journal of translational medicine

    Key finding: We demonstrated the higher short-term improvement of cognitive functions scores in individuals of the MedDiet plus low dose of extravirgin olive oil rather than MedDiet alone. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2018-01-18

    Association between palliative care and life-sustaining treatments for patients with dementia: A nationwide 5-year cohort study

    ✓ Peer-reviewed End-of-life care Palliative medicine

    Key finding: Palliative care is related to reduced life-sustaining treatments for patients with dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2018-01-18

    Caring for a family member or friend with dementia at the end of life: A scoping review and implications for palliative care practice

    ✓ Peer-reviewed End-of-life care Palliative medicine

    Key finding: Palliative care services would benefit from ensuring holistic approaches to supporting people with dementia, their carers and wider family networks.

    Full summary, score breakdown and related studies → Original source

  22. 2018-01-18

    Effects of Cognitive Training on Cognition and Quality of Life of Older Persons with Dementia

    ✓ Peer-reviewed Prevention trials Journal of the American Geriatrics Society

    Key finding: Systematic cognitive training had no effect on global cognition or HRQoL in community-living persons with mild to moderate dementia.

    Full summary, score breakdown and related studies → Original source

  23. 2018-01-18

    Risk of progression from subjective cognitive decline to mild cognitive impairment: The role of study setting

    ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Study setting should be considered when evaluating SCD as a risk state for MCI and dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2018-01-18

    Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation

    ✓ Peer-reviewed Lewy body dementia Molecular cell

    Key finding: These results highlight the mechanistic role of specific LC domain interactions and modifications conserved across many hnRNP family members but altered by aggregation-causing pathological mutations.

    Full summary, score breakdown and related studies → Original source

  25. 2018-01-17

    Brain-Derived Neurotrophic Factor and Major Depressive Disorder: Evidence from Meta-Analyses

    ✓ Peer-reviewed Hippocampus size on brain scans Frontiers in psychiatry

    Key finding: Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with the pathophysiology of major depressive disorder (MDD). +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →