Newest studies

Panax ginseng and Panax quinquefolius: From pharmacology to toxicology

45/100 ✓ Peer-reviewed Risk factors Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Key finding: Over the past few years, extensive preclinical and clinical evidence in the scientific literature worldwide has supported the beneficial effects of P. ginseng and P. quinquefolius in significant central nervous system, metabolic, infectious and neoplastic diseases.

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Overview of systematic reviews: Effective home support in dementia care, components and impacts-Stage 1, psychosocial interventions for dementia

38/100 ✓ Peer-reviewed Prevention trials Journal of advanced nursing

Key finding: There was a lack of definitive evidence of effectiveness for most psychosocial interventions. +1 more finding

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The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma

48/100 ✓ Peer-reviewed Lewy body dementia Frontiers in aging neuroscience

Key finding: In this pathology, deposition of Aβ, synuclein, and pTau has also been detected in retina. +4 more findings

• Other Dementias
• Brain Biology

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Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis

78/100 ✓ Peer-reviewed Prevention and risk Sleep medicine reviews

Key finding: Sleep disturbances and dementia are two common and significant health problems in older adults. +4 more findings

• Risk Factors
• Lifestyle

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Pathology of Neurodegenerative Diseases

54/100 ✓ Peer-reviewed Lewy body dementia Cold Spring Harbor perspectives in biology

Key finding: Growing experimental evidence suggests that abnormal protein conformers may spread from cell to cell along anatomically connected pathways, which may in part explain the specific anatomical patterns observed at autopsy.

• Other Dementias
• Brain Biology

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Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults

63/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Self-report of poor sleep was associated with greater AD-related pathology in cognitively healthy adults at risk for AD. +2 more findings

• Biomarkers
• Early Stage
• Brain Biology

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NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

41/100 ✓ Peer-reviewed Genetics Redox Biology

Key finding: Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy alone provide an incomplete view of disease. +3 more findings

• Brain Biology

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Effect of long-term exposure to air pollution on anxiety and depression in adults: A cross-sectional study

47/100 ✓ Peer-reviewed Risk factors International journal of hygiene and environmental health

Key finding: Our study shows that increasing long-term exposure to air pollution may increase the odds of depression and the use of antidepressants and benzodiazepines. +2 more findings

• Risk Factors

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Experiences of end of life amongst family carers of people with advanced dementia: longitudinal cohort study with mixed methods

57/100 ✓ Peer-reviewed End-of-life care BMC geriatrics

Key finding: Regular health status updates and end of life discussions can help families understand dementia progression and prepare for end of life. +1 more finding

• Caregiving
• End-of-Life Care

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Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study

62/100 ✓ Peer-reviewed Inflammation and the immune system The Lancet. Neurology

Key finding: Neuroinflammation in the form of microglial activation is present in synucleinopathies and is a potential therapeutic target to halt or delay the neurodegenerative process. +3 more findings

• Brain Biology
• Other Dementias
• Lifestyle

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Predicting discharge to institutional long-term care following acute hospitalisation: a systematic review and meta-analysis

86/100 ✓ Peer-reviewed Health systems and care delivery Age and ageing

Key finding: from 9,176 records, we included 23 studies (n = 354,985 participants). +4 more findings

• Care Services

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Emerging concepts in sporadic cerebral amyloid angiopathy

43/100 ✓ Peer-reviewed Vascular contributions Brain : a journal of neurology

Key finding: This review provides an interdisciplinary critical outlook on various emerging and changing concepts in the field, illustrating mechanisms associated with amyloid cerebrovascular pathology and neurological dysfunction.

• Brain Scans

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[DIAN/DIAN-J/DIAN-TU]

39/100 ✓ Peer-reviewed Risk genes beyond APOE Brain and nerve = Shinkei kenkyu no shinpo

Key finding: This study revealed that changes in the biomarkers in the mutation carrier's brain start as early as 20 or even 25 years prior to the onset of symptoms.

• Genetics
• Treatments

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Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football

50/100 ✓ Peer-reviewed Brain tissue and pathology JAMA

Key finding: In a convenience sample of deceased football players who donated their brains for research, a high proportion had neuropathological evidence of CTE, suggesting that CTE may be related to prior participation in football. +2 more findings

• Other Dementias

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Clinical criteria for subtyping Parkinson's disease: biomarkers and longitudinal progression

66/100 ✓ Peer-reviewed Tau biomarkers Brain : a journal of neurology

Key finding: Data from deformation-based magnetic resonance imaging morphometry demonstrated a Parkinson's disease-specific brain network had more atrophy in the diffuse malignant subtype, with the mild motor-predominant subtype having the least atrophy. +3 more findings

• Biomarkers
• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

The 2017 hormone therapy position statement of The North American Menopause Society

38/100 ✓ Peer-reviewed Vascular contributions Menopause (New York, N.Y.)

Key finding: For women who initiate HT more than 10 or 20 years from menopause onset or are aged 60 years or older, the benefit-risk ratio appears less favorable because of the greater absolute risks of coronary heart disease, stroke, venous thromboembolism, and dementia. +3 more findings

• Treatments

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Attitudes Toward Advance Directives Among Patients and Their Family Members in China

59/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

Key finding: Among 1084 patients who completed the questionnaire, 415 (38.3%) had heard about ACP/ADs. +1 more finding

• End-of-Life Care

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Epidemiology, Pathophysiology, and Prognosis of Heart Failure in Older Adults

38/100 ✓ Peer-reviewed Clinical safety Heart failure clinics

Key finding: Heart failure is the quintessential cardiovascular syndrome of aging that results from common cardiovascular conditions in older adults in conjunction with age-associated changes in cardiovascular structure and function.

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[O1–04–03]: NEIGHBORHOOD SOCIOECONOMIC CONTEXTUAL DISADVANTAGE, BASELINE COGNITION AND ALZHEIMER's DISEASE BIOMARKERS IN THE WISCONSIN REGISTRY FOR ALZHEIMER's PREVENTION (WRAP) STUDY

41/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Neighborhood disadvantage is associated with education, health behaviors and mortality. +4 more findings

• Health Equity

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[P2–526]: GEOGRAPHICAL VARIATIONS IN DIAGNOSTIC RATES FOR DEMENTIA WITH LEWY BODIES IN CLINICAL SERVICES

34/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Significant variation was observed between services, with DLB prevalence ranging from 1.8% to 5.9% (χ=24.3, p<0.01). +2 more findings

• Other Dementias
• Diagnosis

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[P4–555]: A SYSTEMATIC REVIEW AND META‐ANALYSIS OF THE PREVALENCE OF DEMENTIA IN MAINLAND CHINA, HONG KONG AND TAIWAN: 2017 UPDATE

35/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: The results of meta-regression were used to estimate number of people with dementia by geographical areas. +2 more findings

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[O5–03–03]: LEVERAGING MEDICARE CLAIMS TO CHARACTERIZE DIAGNOSTIC PATHWAYS IN ALZHEIMER's DISEASE

27/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: The primary aims of this analysis were to: (1) characterize the temporal relationship between diagnostic and treatment codes associated with AD; and (2) explore the pre-diagnostic claims record for the appearance of codes suggestive of AD-related symptoms. +2 more findings

• Treatments
• Diagnosis
• Policy

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[P2–557]: HEALTH CARE USE AMONG NEWLY DIAGNOSED ALZHEIMER's (AD) PATIENTS IN A U.S. COMMERCIAL MEDICARE ADVANTAGE INSURANCE PLAN

29/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: Increases in the mean number of monthly outpatient visits (80%), emergency room visits (502%), inpatient stays (829%) and medication use (22%) were observed in the index month, compared to the 12 months prior to index.

• Policy

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Sexual Activity and Physical Tenderness in Older Adults: Cross-Sectional Prevalence and Associated Characteristics

52/100 ✓ Peer-reviewed Long-term cohort studies The journal of sexual medicine

Key finding: Despite a common misconception, older adults engage in sexual behavior. +3 more findings

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Association of Dual-Task Gait With Incident Dementia in Mild Cognitive Impairment: Results From the Gait and Brain Study

68/100 ✓ Peer-reviewed Mild cognitive impairment JAMA neurology

Key finding: Among 112 study participants with MCI, mean (SD) age was 76.6 (6.9) years, 55 were women (49.1%), and 27 progressed to dementia (24.1%), with an incidence rate of 121 per 1000 person-years. +2 more findings

• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source