Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 13,551–13,575 of 27,380 studies, newest first · page 543 of 1096.
October 2018 25
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2018-10-23
Polygenic Score for Alzheimer Disease and cognition: The mediating role of personality
39/100 ✓ Peer-reviewed Genetics Journal of psychiatric research
Key finding: Alzheimer's disease (AD) polygenic risk score (PGS) is associated with lower cognitive functioning even among older individuals without dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-23
Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects
43/100 ✓ Peer-reviewed Prevention and risk Clinical nutrition research
Key finding: Recent reports have demonstrated that hyperglycemia is closely related to the development of cognitive impairment and dementia, suggesting that there may be a cause-effect relationship between hyperglycemia and dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-10-22
DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer’s Disease
41/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer s Disease
Key finding: Differentially methylated positions (DMPs) between persons with and without late-onset Alzheimer's disease (LOAD) were observed at 477 of 769,190 loci in a plurality of genes. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-22
Prolonged Drug-Releasing Fibers Attenuate Alzheimer's Disease-like Pathogenesis
39/100 ✓ Peer-reviewed Drug development ACS applied materials & interfaces
Key finding: Here, a biodevice is produced by electrospinning PLA with a GLP-1 analogue (liraglutide, LG), coated with a thin layer of gelatin. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-21
Multidomain Lifestyle Intervention Strategies for the Delay of Cognitive Impairment in Healthy Aging
39/100 ✓ Peer-reviewed Prevention trials Nutrients
Key finding: This shift in population consequently results in many social and economic problems, which burden the social and economic systems of countries. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-21
Occupational therapy practice in oncology care: Results from a survey
35/100 ✓ Peer-reviewed Health systems and care delivery Nursing and Health Sciences
Key finding: The everyday landscape of occupational therapy (OT) in oncology is underexplored, hindering targeted improvements. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-10-20
Tooth loss as a risk factor for dementia: systematic review and meta-analysis of 21 observational studies
62/100 ✓ Peer-reviewed Disparities BMC psychiatry
Key finding: Future well-designed longitudinal researches examining the direct and indirect relationship between tooth loss and dementia risk are encouraged. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-19
Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer's Disease
45/100 ✓ Peer-reviewed Costs and economics Frontiers in aging neuroscience
Key finding: The striking results show that the risk of SD is much greater in those who are HSV-seropositive than in seronegative subjects, and that antiviral treatment causes a dramatic decrease in number of subjects who later develop SD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-19
The global burden of multiple chronic conditions: A narrative review
45/100 ✓ Peer-reviewed Risk factors Preventive medicine reports
Key finding: Certain conditions cluster together more frequently than expected, with associations of up to three-fold, e.g. depression associated with stroke and with Alzheimer's disease, and communicable conditions such as TB and HIV/AIDS associated with diabetes and CVD, respectively.
Full summary, score breakdown and related studies → Original source
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2018-10-19
Multisite study of the relationships between antemortem [ 11 C]PIB‐PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology
54/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer s & Dementia
Our study demonstrated the robustness of a multisite Centiloid [ 11 C]PIB‐PET study and established a range of pathology‐based CL thresholds.
Full summary, score breakdown and related studies → Original source
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2018-10-19
Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia
47/100 ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica communications
Key finding: Despite considerable progress in the understanding of the pathophysiology of AD, the precise molecular mechanisms that cause the disease remain elusive. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-19
Surgery, neuroinflammation and cognitive impairment
48/100 ✓ Peer-reviewed Caregiving EBioMedicine
Key finding: Post-surgical neuroinflammation is a documented phenomenon that results in synaptic impairment, neuronal dysfunction and death, and impaired neurogenesis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-18
Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy
41/100 ✓ Peer-reviewed Treatments Frontiers in pharmacology
Key finding: This feature makes acetylcholinesterase inhibitors (AChEi) the main class of drugs currently used for the treatment of AD dementia phase, among which galantamine is the only naturally occurring substance. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-18
Triggered Palliative Care for Late-Stage Dementia: A Pilot Randomized Trial
72/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: Specialty palliative care consultation for hospitalized patients with late-stage dementia is feasible and promising to improve decision-making and some treatment outcomes.
Full summary, score breakdown and related studies → Original source
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2018-10-18
Towards Combinatorial Approaches for Preserving Cognitive Fitness in Aging
38/100 ✓ Peer-reviewed Prevention trials Trends in neurosciences
Key finding: Aging-related cognitive decline represents a critical risk factor for the development of dementia and is associated with global neurophysiological changes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-10-18
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS
41/100 ✓ Peer-reviewed Disease mechanisms Neuron
Key finding: Through the generation of humanized FUS mice expressing full-length human FUS, we identify that when expressed at near endogenous murine FUS levels, both wild-type and ALS-causing and frontotemporal dementia (FTD)-causing mutations complement the essential function(s) of murine FUS. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-17
Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis
41/100 ✓ Peer-reviewed Vascular contributions BMC neuroscience
Key finding: Efficient blood supply to the brain is of paramount importance to its normal functioning and improper blood flow can result in potentially devastating neurological consequences.
Full summary, score breakdown and related studies → Original source
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2018-10-17
Sex differences in Alzheimer's disease and common neuropathologies of aging
70/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica
Key finding: However, few pathological studies have addressed sex difference in Alzheimer's disease (AD) and other brain pathologies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-17
Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke
69/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: MoCA was administered to 274 patients from 2 prospective hospital-based cohort studies in Germany (n = 125) and France (n = 149). +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-17
Efficacy and safety of programmable compared with fixed anti-siphon devices for treating idiopathic normal-pressure hydrocephalus (iNPH) in adults - SYGRAVA: study protocol for a randomized trial
55/100 ✓ Peer-reviewed Treatments Trials
Key finding: SYGRAVA is the first randomized trial to determine whether programmable ASDs reduce complications of drainage compared to fixed ASDs in patients with iNPH. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-16
AMYPAD Diagnostic and Patient Management Study: Rationale and design
52/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Reimbursement of amyloid-positron emission tomography (PET) is lagging due to the lack of definitive evidence on its clinical utility and cost-effectiveness. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-16
Can Transcranial Direct-Current Stimulation Alone or Combined With Cognitive Training Be Used as a Clinical Intervention to Improve Cognitive Functioning in Persons With Mild Cognitive Impairment and Dementia? A Systematic Review and Meta-Analysis
69/100 ✓ Peer-reviewed Prevention trials Frontiers in human neuroscience
Key finding: Twelve studies with 195 PwD and four with 53 PwMCI met the inclusion criteria. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-15
Fighting the Cause of Alzheimer's and GNE Myopathy
39/100 ✓ Peer-reviewed Disease mechanisms Frontiers in neuroscience
Key finding: Individuals with mutations in presenilin or amyloid precursor protein (APP) gene develop AD while mutations in GNE (UDP N-acetylglucosamine 2 epimerase/N-acetyl Mannosamine kinase), key sialic acid biosynthesis enzyme, cause GNEM. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-15
Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome
52/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: We report for the first time an association between altered BA profile, genetic variants implicated in AD, and cognitive changes in disease using a large multicenter study. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-15
Hearing impairment and the risk of neurodegenerative dementia: A longitudinal follow-up study using a national sample cohort
50/100 ✓ Peer-reviewed Risk factors Scientific reports
Key finding: The severe hearing impairment group showed an increased risk of dementia (adjusted HR = 1.17, 95% confidence interval [CI] = 1.04-1.31, P = 0.010). +2 more findings
Full summary, score breakdown and related studies → Original source
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