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Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis
Pal K, Mukadam N, Petersen I, Cooper C.. Social psychiatry and psychiatric epidemiology, 2018-09-04
Topic: Risk, prevention and care in population studies
Plain-language summary
Purpose We aimed to quantify the relative risk of progression from mild cognitive impairment (MCI) to dementia in people with and without diabetes, and with and without the MetS (MetS); and to identify potential modifiers of the risk of progression from MCI to dementia in people with diabetes or MetS. Methods We searched Medline, Embase, PsycINFO, PsycArticles and Web of Science from inception through to 20th March 2018. Where possible, the results from three or more studies were pooled in a meta-analysis, while other findings have been described narratively. Results We included 15 articles reporting 12 studies (6865 participants). The overall unadjusted pooled odds ratio for the progression of MCI to dementia in people with diabetes/MetS was 1.67 (95% CI 1.27-2.19); the pooled odds ratio for progression in diabetes + MCI was 1.53 (95% CI 1.20-1.97) and in people with MetS + MCI was 2.95 (95% CI 1.23-7.05). There was moderate heterogeneity in the included studies (I 2 Conclusions Diabetes and MetS were both associated with an increased incidence of dementia when co-existing with MCI. Intensive cardiovascular risk reduction and lifestyle changes for patients presenting with MCI and diabetes, prediabetes or MetS may be important in reducing incidence of dementia in this high risk population.
What this study adds
Evidence grade: High
This is a pooled review of 15 participants. People with mild cognitive impairment who also had diabetes or metabolic syndrome were more likely to progress to dementia. The authors suggest intensive cardiovascular risk reduction and lifestyle changes may be important for these high-risk patients, though this was not directly tested.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Pal, K., Mukadam, N., Petersen, I., & Cooper, C. (2018). Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis. Social psychiatry and psychiatric epidemiology. https://doi.org/10.1007/s00127-018-1581-3
Vancouver
Pal K, Mukadam N, Petersen I, Cooper C. Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis. Social psychiatry and psychiatric epidemiology. 2018. doi:10.1007/s00127-018-1581-3. PMID: 30182156.
BibTeX
@article{pal2018-30182156,
author = {Pal, K. and Mukadam, N. and Petersen, I. and Cooper, C.},
title = {{Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis}},
journal = {Social psychiatry and psychiatric epidemiology},
year = {2018},
doi = {10.1007/s00127-018-1581-3},
pmid = {30182156},
url = {https://doi.org/10.1007/s00127-018-1581-3}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Where possible, the results from three or more studies were pooled in a meta-analysis, while other findings have been described narratively.
- Results We included 15 articles reporting 12 studies (6865 participants).
- The overall unadjusted pooled odds ratio for the progression of MCI to dementia in people with diabetes/MetS was 1.67 (95% CI 1.27-2.19); the pooled odds ratio for progression in diabetes + MCI was 1.53 (95% CI 1.20-1.97) and in people with MetS + MCI was 2.95 (95% CI 1.23-7.05).
- There was moderate heterogeneity in the included studies (I 2 Conclusions Diabetes and MetS were both associated with an increased incidence of dementia when co-existing with MCI.
Why it matters
People with mild cognitive impairment who also had diabetes or metabolic syndrome were more likely to progress to dementia. The authors suggest intensive cardiovascular risk reduction and lifestyle changes may be important for these high-risk patients, though this was not directly tested.
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Study details
- Study designmeta-analysis
- Participants15
- Evidence strengthHigh
How this study scored 68/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Social psychiatry and psychiatric epidemiology) |
| Journal's citation record | 2 / 4 | Social Psychiatry and Psychiatric Epidemiology: journal h-index 200 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 15 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | A review of other studies — randomization is not credited here |
| Times cited | 5 / 7 | Cited 275 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 27.5 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 3 / 6 | Cited 4.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 3 / 4 | Cited 88 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Claudia Cooper: h-index 66 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30182156) |
| Free to read | 2 / 2 | Free to read |
| Total | 68 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1007/s00127-018-1581-3
- PubMed: 30182156
- Original source →
- Free full text: Social Psychiatry and Psychiatric Epidemiology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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