Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 13,801–13,825 of 27,380 studies, newest first · page 553 of 1096.
August 2018 1
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2018-08-01
Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study
65/100 ✓ Peer-reviewed Prevention and risk BMJ
Key finding: Long-term abstainers had a 47% higher risk of dementia than moderate drinkers (1-14 units/week) +3 more findings
Full summary, score breakdown and related studies → Original source
July 2018 24
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2018-07-31
A pathogenic PSEN2 p.His169Asn mutation associated with early-onset Alzheimer's disease
45/100 ✓ Peer-reviewed Risk genes beyond APOE Clinical interventions in aging
Key finding: A pathogenic mutation in the PSEN2 gene in a Korean patient associated with EOAD was identified. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-31
In vivo quantification of neurofibrillary tangles with [ 18 F]MK-6240
48/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's research & therapy
Key finding: This evaluation shows an [ 18 F]MK-6240 distribution in concordance with postmortem studies and that simplified quantitative approaches such as the SUVR offer valid estimates of neurofibrillary tangle load 90 min post injection. [ 18 F]MK-6240 is a promising tau tracer with the potential to be applied in the disease diagnosis and assessment of therapeutic interventions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-07-31
Pharmacologic Depletion of Microglia Increases Viral Load in the Brain and Enhances Mortality in Murine Models of Flavivirus-Induced Encephalitis
43/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of virology
Key finding: However, the exact mechanisms of injury to the central nervous system (CNS) during flavivirus infections remain poorly understood. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-31
Current understanding of Alzheimer's disease diagnosis and treatment
56/100 ✓ Peer-reviewed Getting a diagnosis F1000Research
Key finding: Treatment is currently targeted toward symptomatic therapy, although trials are underway that aim to reduce the production and overall burden of pathology within the brain.
Full summary, score breakdown and related studies → Original source
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2018-07-30
Quality of end-of-life care in patients with dementia compared to patients with cancer: A population-based register study
52/100 ✓ Peer-reviewed End-of-life care PloS one
Key finding: A subgroup of patients with Alzheimer's disease was identified and compared to patients with other and unspecified types of dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-28
Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis
41/100 ✓ Peer-reviewed Biomarkers BMC neuroscience
Key finding: App NL/NL and App NL-G-F/NL-G-F mice exhibit behavioral changes associated with non-cognitive, emotional domains before the onset of definitive cognitive deficits. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-28
Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer's disease
59/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's research & therapy
Key finding: A growing body of evidence suggests that the plasma concentration of the neurofilament light chain (NfL) might be considered a plasma biomarker for the screening of neurodegeneration in Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-28
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease
50/100 ✓ Peer-reviewed Digital health tools Autophagy
Key finding: Two genes associated with recessive, early-onset PD encode the ubiquitin (Ub) kinase PINK1 and the E3 Ub ligase PRKN/PARK2/Parkin, which together orchestrate a protective mitochondrial quality control (mitoQC) pathway. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-27
Prevalence and Costs of Discharge Diagnoses in Inpatient General Internal Medicine: a Multi-center Cross-sectional Study
57/100 ✓ Peer-reviewed Digital health tools Journal of general internal medicine
Key finding: GIM services care for a markedly heterogeneous population but the most common conditions were similar across 7 hospitals. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-27
Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
38/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of visualized experiments : JoVE
Key finding: Driving sensors are also installed in participants' cars and computer (PC, tablet or smartphone) use is tracked. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-27
CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease
73/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Neuroinflammation and cerebrovascular dysfunction are early events occurring already at presymptomatic stages of AD and contribute to disease progression. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-25
Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound
50/100 ✓ Peer-reviewed Brain scans and imaging Nature communications
Key finding: Opening the blood-brain barrier did not result in serious clinical or radiographic adverse events, as well as no clinically significant worsening on cognitive scores at three months compared to baseline. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-07-25
Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease
47/100 ✓ Peer-reviewed Tau biomarkers Nature
Key finding: Impairment of meningeal lymphatic function slows paravascular influx of macromolecules into the brain and efflux of macromolecules from the interstitial fluid, and induces cognitive impairment in mice. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-25
Estimating the survival of elderly patients diagnosed with dementia in Taiwan: A longitudinal study
69/100 ✓ Peer-reviewed End-of-life care PloS one
Key finding: The survival prediction model demonstrated moderate accuracy for predicting mortality at 6 and 12 months before death in elderly patients with dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-07-25
Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline
62/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: We analyzed data from 11,709 participants without a history of coronary heart disease or stroke who attended the baseline examination (1987-1989) of the prospective Atherosclerosis Risk in Communities (ARIC) study. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-24
The Molecular Intersection Between Senescence and Major Depression in the Elderly
39/100 ✓ Peer-reviewed Risk factors The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: They also have a higher risk of developing cognitive impairment with progression to dementia and higher rates of medical comorbidity, frailty, and mortality.
Full summary, score breakdown and related studies → Original source
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2018-07-24
The link of organophosphorus pesticides with neurodegenerative and neurodevelopmental diseases based on evidence and mechanisms
38/100 ✓ Peer-reviewed Risk factors Toxicology
Key finding: Neurodegenerative and neurodevelopmental disorders including Alzheimer, Parkinson, amyotrophic lateral sclerosis (ALS), attention deficit hyperactivity disorder (ADHD), and autism are among the afflicting neurological diseases which overshadow human life and their higher risk in relation to OP exposures have been uncovered by epidemiological studies.
Full summary, score breakdown and related studies → Original source
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2018-07-24
Device-Embedded Cameras for Eye Tracking-Based Cognitive Assessment: Validation With Paper-Pencil and Computerized Cognitive Composites
41/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of medical Internet research
Key finding: Modest relationships were seen between mean VPC novelty preference and the PACC (r=.39, P=.007) and NIHTB-CB (r=.35, P=.03) composite scores, and additional individual neurocognitive task scores including letter fluency (r=.33, P=.02), category fluency (r=.36, P=.01), and Trail Making Test A (-.40, P=.006). +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-24
Effects of creative expression therapy for older adults with mild cognitive impairment at risk of Alzheimer's disease: a randomized controlled clinical trial
69/100 ✓ Peer-reviewed Prevention trials Clinical interventions in aging
Key finding: CrExp therapy has greater positive effects on cognitive functions and daily living ability than standard cognitive training.
Full summary, score breakdown and related studies → Original source
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2018-07-23
Functional and structural connectivity of the amygdala underpins locus of control in mild cognitive impairment
39/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage. Clinical
Key finding: The results showed that both functional and structural connectivity between the medial prefrontal cortex and amygdala were significantly correlated with external LOC. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-07-20
The development and validation of tau PET tracers: current status and future directions
41/100 ✓ Peer-reviewed Brain scans and imaging Clinical and translational imaging
Key finding: Tau PET tracers have enabled in vivo quantification of PHF-tau burden in human brains. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-07-20
Neurodegeneration in diabetic retinopathy: does it really matter?
56/100 ✓ Peer-reviewed Risk factors Diabetologia
Key finding: The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now considered a more complex diabetic complication in which neurodegeneration plays a significant role. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-07-19
Epileptic seizures in autosomal dominant forms of Alzheimer's disease
39/100 ✓ Peer-reviewed Risk genes beyond APOE Seizure
Key finding: Several pieces of evidence report that patients with rare autosomal dominant forms of AD carry a significant risk to develop seizures. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-07-19
Meta-Analysis of 89 Structural MRI Studies in Posttraumatic Stress Disorder and Comparison With Major Depressive Disorder
74/100 ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry
Key finding: The meta-analyses revealed structural brain abnormalities associated with PTSD and trauma and suggest that global brain volume reductions distinguish PTSD from major depression. +4 more findings
Full summary, score breakdown and related studies → Original source
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