Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,176–11,200 of 27,380 studies, newest first · page 448 of 1096.
September 2020 25
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2020-09-22
APOE ε4 and resting-state functional connectivity in racially/ethnically diverse older adults
52/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Compared to APOE ε4 non-carriers, APOE ε4 carriers had lower rsFC in temporal DMN, but only in non-Hispanic Whites. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-22
Remote cognitive and behavioral assessment: Report of the Alzheimer Society of Canada Task Force on dementia care best practices for COVID-19
45/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Despite challenges, current literature and practice support implementation of telemedicine assessments for patients with cognitive impairment.
Full summary, score breakdown and related studies → Original source
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2020-09-22
Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease
62/100 ✓ Peer-reviewed Digital health tools Molecular neurodegeneration
Key finding: With the advent of advanced neuroimaging techniques, such as positron emission tomography (PET) and magnetic resonance imaging (MRI), accumulating evidence has revealed structural and functional brain alterations related to the symptoms of SCD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-21
Impact of COVID-19 related social support service closures on people with dementia and unpaid carers: a qualitative study
47/100 ✓ Peer-reviewed Caregiving Aging & mental health
Key finding: PLWD and carers need to receive specific practical and psychological support during the pandemic to support their well-being, which is severely affected by public health restrictions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-09-21
Supervised Digital Neuropsychological Tests for Cognitive Decline in Older Adults: Usability and Clinical Validity Study
41/100 ✓ Peer-reviewed Cognitive tests and assessment JMIR mHealth and uHealth
Key finding: The positive results pave the way for the deployment of the system to a nonsupervised environment, thus representing a potential efficacious and ecological solution to support clinicians in the identification of early signs of cognitive decline. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-21
Klotho overexpression improves amyloid-β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease
41/100 ✓ Peer-reviewed Disease mechanisms Aging cell
Key finding: The upregulation of Klotho levels in the brain and serum significantly ameliorated Aβ burden, neuronal and synaptic loss and cognitive deficits in aged APP/PS1 mice. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-21
COVID‐19 Pandemic in Assisted Living Communities: Results from Seven States
42/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society
Key finding: State case fatality ranged from 3.32% in North Carolina to 9.26% in Connecticut, but for ALs in these states it was 12.89% and 31.59%, respectively. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-21
β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology
47/100 ✓ Peer-reviewed Brain tissue and pathology Journal of neuroinflammation
Key finding: Recent studies suggest that AD pathology is driven by age-related changes in metabolism. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-21
Classifications of Neurodegenerative Disorders Using a Multiplex Blood Biomarkers-Based Machine Learning Model
49/100 ✓ Peer-reviewed Digital health tools International journal of molecular sciences
Key finding: We observed increased levels of all biomarkers except Aβ40 in the AD group when compared to the MCI and controls. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-21
Brain Functional Magnetic Resonance Imaging Highlights Altered Connections and Functional Networks in Patients With Hypertension
56/100 ✓ Peer-reviewed Brain scans and imaging Hypertension (Dallas, Tex. : 1979)
Key finding: Here, we used resting-state functional magnetic resonance imaging to explore brain functional-hemodynamic coupling across different regions and their connectivity in patients with hypertension, as compared to subjects with normotension. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-21
Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics
44/100 ✓ Peer-reviewed Genetics American journal of human genetics
Key finding: Our simulation studies illustrated that BGW-TWASs achieved higher power compared to existing TWAS methods that do not assess trans-eQTL information. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-20
Subjective Cognitive Decline, Cognitive Reserve Indicators, and the Incidence of Dementia
73/100 ✓ Peer-reviewed Risk factors Journal of the American Medical Directors Association
Key finding: Baseline subjective cognitive decline and low cognitive reserve significantly increased the risk of dementia, after 2 years of follow-up. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-20
Signalling Pathways Implicated in Alzheimer's Disease Neurodegeneration in Individuals with and without Down Syndrome
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's International journal of molecular sciences
Key finding: There is increasing evidence that the neuropathological events associated with AD are interrelated and that many of them not only are implicated in the onset of this pathology but are also a consequence of other alterations.
Full summary, score breakdown and related studies → Original source
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2020-09-20
Benefits of exercise training on cerebrovascular and cognitive function in ageing
52/100 ✓ Peer-reviewed Prevention and risk Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Key finding: Modifiable lifestyle factors that cause a decline in cardiometabolic health, such as physical inactivity, exacerbate these changes beyond those that are associated with normal ageing. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-09-18
Tooth Loss and Dementia: A Critical Examination
67/100 ✓ Peer-reviewed Risk factors Journal of dental research
Key finding: People with better childhood cognitive function have better oral health and access to routine dental care as they go through life, losing fewer teeth along the life course. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-18
The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease
48/100 ✓ Peer-reviewed Brain tissue and pathology Frontiers in neurology
Key finding: AD affects the health of millions of people in the United States and worldwide. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-18
Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation
43/100 ✓ Peer-reviewed Tau biomarkers Journal of neurochemistry
Key finding: To test this hypothesis, we investigated three AD candidate markers (ferritin, fatty acid binding protein 3 (FABP-3), and neurogranin) in interrelation to established AD and inflammatory protein markers. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-18
Accurate Blood-Based Diagnostic Biosignatures for Alzheimer's Disease via Automated Machine Learning
45/100 ✓ Peer-reviewed Digital health tools Journal of clinical medicine
Key finding: In conclusion, using the automated machine learning tool JADBIO, we produced accurate predictive biosignatures extrapolating available low sample -omics data. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-09-16
Interaction between genetic factors, Porphyromonas gingivalis and microglia to promote Alzheimer's disease
39/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of oral microbiology
Key finding: In late-onset Alzheimer disease (AD) pathogenesis, genes, infections and immunity could be significant factors. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-09-16
Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues
50/100 ✓ Peer-reviewed Prevention trials The Lancet. Neurology
Key finding: Neuropsychological research suggests that cognitive processing speed and episodic memory are the most frequently affected cognitive domains.
Full summary, score breakdown and related studies → Original source
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2020-09-16
Drug repositioning and repurposing for Alzheimer disease
48/100 ✓ Peer-reviewed Inflammation and the immune system Nature reviews. Neurology
Key finding: Transcriptional profiling offers a new and highly efficient approach to the identification of novel candidates for repositioning and repurposing. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-15
Are family carers part of the care team providing end-of-life care? A qualitative interview study on the collaboration between family and professional carers
40/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: This qualitative study about the experiences and perceptions of family carers of people with a chronic life-limiting illness living at home regarding the collaboration with different healthcare providers in the last phase life, showed that family carers experience a lot of possibilities, but perceive missed opportunities as well, for healthcare professionals to effectively collaborate with them for palliative care. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-09-15
Alzheimer's disease: Recent treatment strategies
50/100 ✓ Peer-reviewed Drug development European journal of pharmacology
Key finding: Current treatment for AD (donepezil, galantamine, rivastigmine and memantine) is only symptomatic and has modest benefits. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-14
A phase II randomized trial of sodium oligomannate in Alzheimer's dementia
78/100 ✓ Peer-reviewed Clinical trials Alzheimer's research & therapy
Key finding: Comparing with the placebo group (n = 83, change - 1.45), the ADAS-cog12 score change in the GV-971 600-mg group (n = 76) was - 1.39 (p = 0.89) and the GV-971 900-mg group (n = 83) was - 2.58 (p = 0.30). +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-13
Utility of plasma neurofilament light and total tau for clinical trials in Alzheimer's disease
54/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: NfL had a stronger association than t-tau with clinical scales; t-tau did not hold additional information to that given by NfL (P > 0.05 at all time points). +4 more findings
Full summary, score breakdown and related studies → Original source
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