Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 13,051–13,075 of 27,380 studies, newest first · page 523 of 1096.
March 2019 25
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2019-03-06
ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes
61/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: Pooling data across 4 cohort studies, 814 cognitively normal participants (mean baseline age = 59.6 years) were classified into 8 ATN groups using baseline CSF levels of β-amyloid 1-42 as a measure of amyloid (A), phosphorylated tau 181 as a measure of tau (T), and total tau as a measure of neurodegeneration (N). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-06
Health effects of particulate matter air pollution in underground railway systems - a critical review of the evidence
45/100 ✓ Peer-reviewed Disparities Particle and fibre toxicology
Key finding: There is little direct evidence that underground railway particulate matter exposure is more harmful than ambient particulate matter exposure. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-05
A review of the possible associations between ambient PM2.5 exposures and the development of Alzheimer's disease
38/100 ✓ Peer-reviewed Risk factors Ecotoxicology and environmental safety
Key finding: PM2.5 particles in air pollution have been widely considered associated with respiratory and cardiovascular diseases. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-03-05
Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice
41/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration
Key finding: Microglia are the principal innate immune defense cells of the centeral nervous system (CNS) and the target of the human immunodeficiency virus type one (HIV-1). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-05
Diagnostic value of digital clock drawing test in comparison with CERAD neuropsychological battery total score for discrimination of patients in the early course of Alzheimer's disease from healthy individuals
54/100 ✓ Peer-reviewed Digital health tools Scientific reports
Key finding: Our findings suggest that dCDT is a suitable screening tool to identify early cognitive dysfunction.
Full summary, score breakdown and related studies → Original source
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2019-03-05
Effects of a moderate-intensity aerobic exercise programme on the cognitive function and quality of life of community-dwelling elderly people with mild cognitive impairment: A randomised controlled trial
66/100 ✓ Peer-reviewed Prevention and risk International journal of nursing studies
Key finding: Whether the cognitive benefits of physical exercise can improve the overall well-being of this group remains unknown. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-03-04
The added value of Aβ42/Aβ40 in the CSF signature for routine diagnostics of Alzheimer's disease
52/100 ✓ Peer-reviewed Biomarkers Clinica chimica acta; international journal of clinical chemistry
Key finding: Our study showed that the use of CSF Aβ42/Aβ40 could significantly improve the routine diagnostic work up of AD.
Full summary, score breakdown and related studies → Original source
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2019-03-04
Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System
41/100 ✓ Peer-reviewed Biomarkers Frontiers in immunology
Key finding: There have been a few recent clinical trials of available anti-complement drugs in CNS diseases associated with BBB impairment, for example the use of the anti-C5 monoclonal antibody (mAb) eculizumab in NMO, but for most CNS diseases there have been no human trials of anti-complement therapies.
Full summary, score breakdown and related studies → Original source
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2019-03-04
Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity
38/100 ✓ Peer-reviewed Prevention trials Behavioural brain research
Key finding: Considering that physical exercise neuroprotective effects on prevention of cognitive deficits are well elucidate, it is important clarify the effects of cognitive training, and verify if they are similar or comparable to those observed for physical exercise. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-04
Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study
53/100 ✓ Peer-reviewed Long-term cohort studies PloS one
Key finding: Fibroblast growth factor 23 is an emerging vascular biomarker, recently associated with cerebral small vessel disease and poor cognition in patients on dialysis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-04
DIVE: A spatiotemporal progression model of brain pathology in neurodegenerative disorders
53/100 ✓ Peer-reviewed Long-term cohort studies NeuroImage
Key finding: Such models are unable to recover fine details of atrophy patterns; they tend to impose an assumption of strong spatial correlation within each ROI and no correlation among ROIs. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-04
Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease
56/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The four emerging CSF biomarkers were significantly elevated in the mutation carriers (n = 235) versus noncarriers (n = 145). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-02
What the NHS Long-Term Plan means for dementia care
22/100 ✓ Peer-reviewed Health systems and care delivery Nursing and Residential Care
Key finding: In January, the NHS presented its long-awaited plan to transform care over the next 10 years. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-03-02
Potential Diagnostic Value of Red Blood Cells α-Synuclein Heteroaggregates in Alzheimer's Disease
43/100 ✓ Peer-reviewed Biomarkers Molecular neurobiology
Key finding: Our aim is to find whether RBC concentrations of α-syn and its heterocomplexes (i.e., α-syn/Aβ and α-syn/tau) were different in AD patients compared with healthy controls (HC). +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-03-01
Presenilins and γ-Secretase in Membrane Proteostasis
39/100 ✓ Peer-reviewed Disease mechanisms Cells
Key finding: The two homologous proteins PS1 and PS2 represent the catalytic subunits of distinct γ-secretase complexes that mediate a variety of cellular processes, including membrane protein metabolism, signal transduction, and cell differentiation. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03 month only
Dementia prevention and reserve against neurodegenerative disease
39/100 ✓ Peer-reviewed Risk factors Dialogues in clinical neuroscience
Key finding: The concept of reserve was developed based on the observation that certain individual characteristics, such as life experiences, lifestyles, and neurobiological parameters, are associated with a higher resilience against neurodegeneration and its symptoms.
Full summary, score breakdown and related studies → Original source
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2019-03 month only
Hearing interventions to prevent dementia
46/100 ✓ Peer-reviewed Risk factors HNO
Key finding: Seven studies of hearing interventions with cognitive outcomes assessed over longer than 3 years are reviewed. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Effectiveness of Implementing a Collaborative Chronic Care Model for Clinician Teams on Patient Outcomes and Health Status in Mental Health: A Randomized Clinical Trial
85/100 ✓ Peer-reviewed Digital health tools JAMA network open
Key finding: Implementation facilitation that engages clinicians under typical practice conditions can enhance evidence-based team processes; its effect on self-reported overall population health status was negligible, although health status improved for individuals with complex conditions and hospitalization rate declined. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Drugs Contributing to Anticholinergic Burden and Risk of Fall or Fall-Related Injury among Older Adults with Mild Cognitive Impairment, Dementia and Multiple Chronic Conditions: A Retrospective Cohort Study
71/100 ✓ Peer-reviewed Digital health tools Drugs & aging
Key finding: The same daily ACB score was associated with a different degree of risk, depending on the ACB ratings of the individual drugs comprising the score. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases
38/100 ✓ Peer-reviewed Drug development CNS drugs
Key finding: We review studies revealing the neuroprotective actions of GLP-1 analogues in pre-clinical models of AD and PD and promising results from recent clinical trials.
Full summary, score breakdown and related studies → Original source
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2019-03-01
A Quarter Century of APOE and Alzheimer's Disease: Progress to Date and the Path Forward
38/100 ✓ Peer-reviewed Genetics Neuron
Key finding: This view is clouded, however, by lingering uncertainty over how to treat the quasi "monogenic" role of apolipoprotein E (APOE). +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimer's disease
52/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology
Key finding: We found significant correlations of plasma p-tau, t-tau, p-tau/amyloid-β1-42, and t-tau/amyloid-β1-42 with brain tau deposition in cross-sectional and longitudinal manners. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Assessment of Reported Comparative Effectiveness and Safety of Atypical Antipsychotics in the Treatment of Behavioral and Psychological Symptoms of Dementia: A Network Meta-analysis
86/100 ✓ Peer-reviewed Clinical safety JAMA network open
Key finding: Seventeen studies (5373 patients) were included. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Essential oils and functional herbs for healthy aging
41/100 ✓ Peer-reviewed Prevention trials Neural regeneration research
Key finding: It has been shown that aromatherapy with essential oils from the mint family can improve cognitive performance in Alzheimer's disease patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-03-01
The Role of Nutrition for the Aging Population: Implications for Cognition and Alzheimer's Disease
38/100 ✓ Peer-reviewed Prevention trials Annual review of food science and technology
Key finding: Improved life expectancy worldwide has resulted in a significant increase in age-related diseases. +2 more findings
Full summary, score breakdown and related studies → Original source
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