Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,176–26,200 of 27,380 studies, newest first · page 1048 of 1096.
April 1997 13
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1997-04-01
Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia
47/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: The pathological hallmark of AD is the presence of numerous senile plaques throughout the hippocampus and cerebral cortex associated with degenerating axons, neurofibrillary tangles, and gliosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-04-01
Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease
16/100 ⚠ Retracted — do not rely on it Brain tissue and pathology Proceedings of the National Academy of Sciences of the United States of America
Key finding: Cytochrome c oxidase (CO) is kinetically abnormal, and its activity is decreased in brain and peripheral tissue in late-onset AD. +3 more findings
Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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1997-04-01
Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons
44/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: In non-neuronal cells beta A4 has been shown to be secreted via a pH-sensitive and endocytosis-dependent pathway, and this process, when occurring in the brain, is considered to play an important role in AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-04-01
Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
48/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: Permeabilized cells were prepared following metabolic labeling and incubation at 20 degrees C, a temperature that allows beta APP to accumulate in the trans-Golgi network (TGN) without concomitant A beta formation. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-04-01
The pathogenesis of senile plaques
50/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology
Key finding: Evidence suggests that diffuse, neurocentric amyloid deposits evolve over time with formation of discrete niduses that eventually become neuritic SP. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-04-01
Down syndrome
31/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Current opinion in neurology
Key finding: Down syndrome, trisomy of chromosome 21, is well investigated because it is a genetic disease with characteristic mental retardation and precocious dementia of Alzheimer type. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-04-01
A study of the Lund-Manchester research criteria for frontotemporal dementia: clinical and single-photon emission CT correlations
50/100 ✓ Peer-reviewed Digital health tools Neurology
Key finding: These patients were compared with 30 with a research diagnosis of Alzheimer's disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-04-01
Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stage
42/100 ✓ Peer-reviewed Caregiving The Journal of infectious diseases
Key finding: There was a significant relationship between increasing CSF virus burden and ADC severity (P = .0006) but not with plasma burden and ADC severity. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-04-01
Community screening for dementia: the Mini Mental State Exam (MMSE) and Modified Mini-Mental State Exam (3MS) compared
47/100 ✓ Peer-reviewed Caregiving Journal of clinical epidemiology
Key finding: The objectives of this study were to assess whether Teng's modification of the Mini-Mental State Examination (MMSE) improves its performance as a screening test for cognitive impairment and dementia, and to replicate this comparison in French and English language groups, and for differing assumptions concerning the relative importance of false negative and false positive errors. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-04-01
Neurocognitive impairment is an independent risk factor for death in HIV infection. San Diego HIV Neurobehavioral Research Center Group
54/100 ✓ Peer-reviewed Prevention and risk Archives of neurology
Key finding: At the baseline evaluation, 256 (62%) of 414 subjects were designated normal; 109 (26%). +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-04-01
Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area
53/100 ✓ Peer-reviewed Prevention and risk Revue neurologique
Key finding: In the 318 subjects drinking 3 to 4 standard glasses per day (> 250 and up to 500 ml), categorized as moderate drinkers, the crude odds ratio (OR) was 0.18 for incident dementia (p < 0.01) and 0.25 for Alzheimer's disease (p < 0.03), as compared to the 971 non-drinkers.
Full summary, score breakdown and related studies → Original source
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1997-04-01
Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease
74/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: Furthermore, the dramatic and favorable effects on disturbing behaviors in AD suggest a novel approach for treatment of noncognitive symptoms.
Full summary, score breakdown and related studies → Original source
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1997-04-01
Astrocyte-apolipoprotein E associations in senile plaques in Alzheimer disease and vascular lesions: a regional immunohistochemical study
36/100 ✓ Peer-reviewed Biomarkers Journal of neuropathology and experimental neurology
Key finding: We found GFAP and ApoE immunoreactivity, but not A beta label in cell bodies and processes of reactive astrocytes in zones of infarction within cerebral cortex, striatum, and cerebellum, indicating that astrocytes are capable of upregulating ApoE within these 3 regions. +1 more finding
Full summary, score breakdown and related studies → Original source
March 1997 12
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1997-03-01
The Course of Psychopathologic Features in Mild to Moderate Alzheimer Disease
55/100 ✓ Peer-reviewed Clinical safety Archives of General Psychiatry
Key finding: Misidentification, wandering or agitation, and physical aggression increased during follow-up. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
The Canadian Study of Health and Aging
59/100 ✓ Peer-reviewed Risk factors Stroke
Key finding: Risk of VaD was associated with history of arterial hypertension (OR, 2.08; 95% confidence interval, 1.29 to 3.35). +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Suicide as an outcome for mental disorders. A meta-analysis
64/100 ✓ Peer-reviewed How common it is The British journal of psychiatry : the journal of mental science
Key finding: If these results can be generalised then virtually all mental disorders have an increased risk of suicide excepting mental retardation and dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-03-01
Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation
50/100 ✓ Peer-reviewed Digital health tools JAMA
Key finding: Other than the early onset, this clinical phenotype is indistinguishable from sporadic AD except that affected individuals frequently complained of headache preceding and during the disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Predicting time to nursing home care and death in individuals with Alzheimer disease
66/100 ✓ Peer-reviewed Vascular contributions JAMA
Key finding: The prediction algorithms are a first but promising step toward providing specific prognoses to patients, families, and practitioners.
Full summary, score breakdown and related studies → Original source
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1997-03-01
The Memorial Delirium Assessment Scale
43/100 ✓ Peer-reviewed Clinical safety Journal of pain and symptom management
Key finding: We conducted two studies with medically hospitalized cancer and acquired immunodeficiency syndrome (AIDS) patients to assess the reliability and validity of a new measure of delirium severity, the Memorial Delirium Assessment Scale (MDAS). +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Glial-neuronal interactions in Alzheimer disease: progressive association of IL-1alpha+ microglia and S100beta+ astrocytes with neurofibrillary tangle stages
36/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuropathology and experimental neurology
Key finding: In this study, we assessed the role of IL-1alpha+ microglia and S100beta+ astrocytes in the pathogenesis of another cardinal histopathological feature of Alzheimer disease: tau2+ neurofibrillary tangles. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Activated Alzheimer disease platelets retain more beta amyloid precursor protein
41/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging
Key finding: Surface labeling demonstrated that there is little APP or CD62 on the surface of resting platelets. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
[Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients].
52/100 ✓ Peer-reviewed Cognitive tests and assessment No to shinkei = Brain and nerve
Key finding: The MMSE scores ranged from 5 to 29 (mean +/- SD = 19.0 +/- 4.8) and the ADAS scores ranged from 7 to 63 (24.3 +/- 10.9). +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Hospitalization of Nursing Home Residents: The Right Rate?
37/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
Key finding: Thus, a region that is reacting to nursing home abuse might impose regulations or enforcement encouraging additional hospitalization of the frail, and a region that has an oversupply of nursing home beds might have younger and healthier residents who more often desire aggressive diagnosis and treatment. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
An Italian Model of Dementia Special Care Unit
38/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer Disease & Associated Disorders
Key finding: Our findings show that transferring demented persons from traditional nursing home wards to an SCU significantly lessens behavioral problems but does not improve functional abilities or cognitive status after a short period of follow-up.
Full summary, score breakdown and related studies → Original source
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1997-03-01
Heritability for Alzheimer's disease: the study of dementia in Swedish twins
51/100 ✓ Peer-reviewed Brain tissue and pathology The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: Alzheimer's disease has been thought to have familial and sporadic forms, and several genetic defects have been identified that chiefly explain early-onset familial cases. +3 more findings
Full summary, score breakdown and related studies → Original source
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