Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,426–12,450 of 27,380 studies, newest first · page 498 of 1096.
October 2019 21
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2019-10-04
Early diagnosis of Alzheimer's disease using combined features from voxel-based morphometry and cortical, subcortical, and hippocampus regions of MRI T1 brain images
51/100 ✓ Peer-reviewed Long-term cohort studies PloS one
Key finding: These methods emphasis only on using the individual feature from sMRI images for the classification of AD, MCI, and HC subjects and their achieved classification accuracy is low. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-04
Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells
49/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular immunology
Key finding: Therefore, the inhibition of overactivated inflammatory M1 microglia by switching to the protective M2 phenotype appears to be a potential therapeutic strategy in neuroinflammatory disorders. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-03
Stress granules and neurodegeneration
55/100 ✓ Peer-reviewed Lewy body dementia Nature reviews. Neuroscience
Key finding: Recent advances suggest that the response of RNA metabolism to stress has an important role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral sclerosis, frontotemporal dementias and Alzheimer disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-10 month only
Neuropathological Findings of Dementia Associated With Subjective Hearing Loss
43/100 ✓ Peer-reviewed Risk factors Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Key finding: Two-hundred and seventy-three subjects were included, 189 normal hearing and 84 subjective hearing loss subjects. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10 month only
Pathogenic Mechanisms and Therapy Development for C9orf72 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
39/100 ✓ Peer-reviewed Drug development Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Key finding: The proposed disease mechanisms include loss of C9orf72 function and gain of toxicity from the bidirectionally transcribed repeat-containing RNAs. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10 month only
[Genetic Background for Alzheimer's Disease: Knowledge Accumulated from AD GWAS]
68/100 ✓ Peer-reviewed Genetics Brain and nerve = Shinkei kenkyu no shinpo
Key finding: The gene set and disease pathway analysis obtained from the results of GWASs suggested biological mechanisms involving brain immune function, lipid-related processes, tau binding proteins, and degradation of amyloid precursor proteins in the pathogenesis of LOAD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-01
NAD + in Brain Aging and Neurodegenerative Disorders
38/100 ✓ Peer-reviewed Disease mechanisms Cell metabolism
Key finding: NAD + is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-01
The Microbiota-Gut-Brain Axis
38/100 ✓ Peer-reviewed Risk factors Physiological reviews
Key finding: Stress, in particular, can significantly impact the microbiota-gut-brain axis at all stages of life.
Full summary, score breakdown and related studies → Original source
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2019-10-01
Time to test antibacterial therapy in Alzheimer's disease
41/100 ✓ Peer-reviewed Treatments Brain : a journal of neurology
Key finding: Alzheimer's disease is associated with cerebral accumulation of amyloid-β peptide and hyperphosphorylated tau. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-10-01
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
45/100 ✓ Peer-reviewed Genetics Brain : a journal of neurology
Key finding: Neuroinflammation and microglial activation are significant processes in Alzheimer's disease pathology. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-01
Aluminium toxicosis: a review of toxic actions and effects
41/100 ✓ Peer-reviewed Vascular contributions Interdisciplinary toxicology
Key finding: The pathological conditions associated with Al toxicosis are desquamative interstitial pneumonia, pulmonary alveolar proteinosis, granulomas, granulomatosis and fibrosis, toxic myocarditis, thrombosis and ischemic stroke, granulomatous enteritis, Crohn's disease, inflammatory bowel diseases, anemia, Alzheimer's disease, dementia, sclerosis, autism, macrophagic myofasciitis, osteomalacia, oligospermia and infertility, hepatorenal disease, breast cancer and cyst, pancreatitis, pancreatic necrosis and diabetes mellitus.
Full summary, score breakdown and related studies → Original source
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2019-10-01
Diet therapy for the treatment of Alzheimer's disease in view of traditional Persian medicine: A review
41/100 ✓ Peer-reviewed Prevention trials Iranian journal of basic medical sciences
Key finding: Pharmacological studies have been shown that most of the TPM-recommended dietary items can improve memory and cognitive decline and possess anti-amyloidogenic, etc . activities. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-10-01
Mediterranean diet adherence and cognitive function in older UK adults: the European Prospective Investigation into Cancer and Nutrition-Norfolk (EPIC-Norfolk) Study
47/100 ✓ Peer-reviewed Prevention trials The American journal of clinical nutrition
Key finding: Higher adherence to the MedDiet is associated with better cognitive function and lower risk of poor cognition in older UK adults. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-01
Economics of Cochlear Implant Utilization
27/100 ✓ Peer-reviewed Health systems and care delivery The Hearing Journal
Key finding: The decision of whether to utilize CI results from a shared decision-making process involving patients and their providers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-01
Gray Matter Age Prediction as a Biomarker for Risk of Dementia
58/100 ✓ Peer-reviewed Long-term cohort studies Proceedings of the National Academy of Sciences of the United States of America
Key finding: However, owing to the lack of large longitudinal studies, it has been challenging to validate this link. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-01
Implementing a peer-support programme by group videoconferencing for isolated carers of people with dementia
47/100 ✓ Peer-reviewed Digital health tools Journal of telemedicine and telecare
Key finding: Providing peer-support groups using telehealth may have the potential to develop self-sustaining peer networks for isolated caregivers of people with dementia.
Full summary, score breakdown and related studies → Original source
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2019-10-01
APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia
70/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: APOE ε4 may influence the association between WMH and cognitive performance in AD and DLB. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-01
Diagnosis and Management of Dementia: Review
59/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: Dementia is commonly associated with more than 1 neuropathology, usually Alzheimer disease with cerebrovascular pathology.
Full summary, score breakdown and related studies → Original source
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2019-10-01
Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial
66/100 ✓ Peer-reviewed Treatments JAMA neurology
Key finding: Statistically significant effects of AZD0530 treatment were not found on relative CMRgl reduction in an Alzheimer disease-associated region of interest or on secondary clinical or biomarker measures. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-01
The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes
71/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology
Key finding: These two conclusions support a dynamic biomarker model in which Alzheimer's disease is characterized first by the appearance of amyloidosis and later by tauopathy, with tauopathy being the proteinopathy associated with clinical symptoms.
Full summary, score breakdown and related studies → Original source
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2019-10-01
Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging-Alzheimer's Association Research Framework
70/100 ✓ Peer-reviewed Biomarkers JAMA neurology
Key finding: These were compared with the prevalence of 3 clinically defined diagnostic groups (mild cognitive impairment or dementia, dementia, and clinically defined probable Alzheimer disease). +3 more findings
Full summary, score breakdown and related studies → Original source
September 2019 4
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2019-09-30
Modeling α-Synuclein Propagation with Preformed Fibril Injections
39/100 ✓ Peer-reviewed Brain tissue and pathology Journal of movement disorders
Key finding: Postmortem analyses of α-syn pathology, especially that of PD, have suggested that aggregates progressively spread from a few discrete locations to wider brain regions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-09-29
Is Alzheimer's disease an inflammasomopathy?
39/100 ✓ Peer-reviewed Inflammation and the immune system Ageing research reviews
Key finding: In the last few years the views about the drivers of AD have been changing and nowadays it is believed that neuroinflammation takes center stage in disease pathogenesis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-27
Nutrition and immunology in mental health: Precision medicine and integrative approaches to address unmet clinical needs in psychiatric treatments
46/100 ✓ Peer-reviewed Prevention and risk Brain, behavior, and immunity
Key finding: Accumulating evidence suggests that inflammatory regulation plays an important role in pathophysiology and therapeutic mechanism across the major psychiatric disorders. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-09-27
The Health and Retirement Study Harmonized Cognitive Assessment Protocol Project: Study Design and Methods
64/100 ✓ Peer-reviewed Caregiving Neuroepidemiology
Key finding: Linking detailed HCAP cognitive assessments to the wealth of available longitudinal HRS data on cognition, health, biomarkers, genetics, health care utilization, informal care, and economic resources and behavior will provide unique and expanded opportunities to study cognitive impairment and dementia in a nationally representative US population-based sample. +4 more findings
Full summary, score breakdown and related studies → Original source
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