Newest studies

Small palpebral fissure as a significant risk factor for glaucoma surgery failure

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: Small palpebral fissure is an independent and previously unnoticed risk factor for glaucoma surgical failure, affecting both minimally invasive and filtration procedures. +2 more findings

• Risk Factors

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Alzheimer disease β-amyloid pathology accelerates age-related hearing loss: evidence from App NL-F “knock-in” mice

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: We found evidence that the early-onset ARHL of the C57BL/6J mouse is accelerated in the App NL-F mouse. +4 more findings

• Risk Factors
• Brain Biology
• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Loss of SMARCAD1 Mitigates Tauopathy

35/100 ✓ Peer-reviewed Disease mechanisms Aging Cell

Key finding: Loss of smrd-1 function rescues tauopathy-associated neuronal dysfunction and neurodegeneration in C. elegans models of tauopathy. +4 more findings

• Brain Biology

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Stem Cell-Derived Extracellular Vesicles Ameliorate the Neuron Mitochondrial Damage Induced by ROS-, LPS-Exposure: In Vitro Model of Neuron, Microglia, and Astrocyte Triple Co-Culture

37/100 ✓ Peer-reviewed Inflammation and the immune system International Journal of Molecular Sciences

Key finding: Cell viability assays revealed that neuronal death occurred mainly through apoptosis and DNA damage.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Tau-PET and CSF MTBR-tau243 comparisons validate increased tau aggregation in females

52/100 ✓ Peer-reviewed Brain scans and imaging European Journal of Nuclear Medicine and Molecular Imaging

Key finding: In both cohorts, CSF MTBR-tau243 was associated with tau-PET temporal meta-ROI burden (BioFINDER-2: β = 1.1, p = < 0.0001 and Knight-ADRC: β = 0.7, p = < 0.0001), and this association did not differ by sex (BioFINDER-2 β = 0.04, p = 0.6 and Knight-ADRC: β = 0.009, p = 0.9). +2 more findings

• Brain Scans
• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Differential associations of core and non-core plasma biomarkers with cognitive performance in Black adults

44/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer s Disease

Key finding: Non-core NfL and GFAP biomarkers are associated with both cross-sectional and longitudinal cognitive performance. +4 more findings

• Biomarkers
• Health Equity
• Diagnosis

Full summary, score breakdown and related studies → Original source

Automated quantification of cerebral microbleeds for ARIA-H monitoring in Aging and Alzheimer’s Disease: A multicenter deep learning validation

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: Notably, the model demonstrated a low false-positive rate, averaging 0.58 false positives (FPs) per scan, an improvement on existing publicly available models.

• Side Effects
• Digital Tools

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Delirium: an urgent health priority in Australian hospitals

40/100 ✓ Peer-reviewed Clinical safety Public Health Research & Practice

Key finding: Delirium is a common health problem with serious and long-lasting health consequences that disproportionately affects vulnerable population groups (especially older people with dementia or frailty). +2 more findings

• Care Services

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Uncovering lipid biomarkers linked to methylphenidate efficacy in treating apathy in Alzheimer's disease: insights from the ADMET 2 trial

54/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer's research & therapy

Key finding: This study aimed to identify lipid species associated with MPH response and explore lipid pathway disruptions in responders versus non-responders. +2 more findings

• Clinical Trials

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BEYOND THE GROCERY STORE: A BIBLIOMETRIC ANALYSIS OF FOOD SUBSCRIPTION BUSINESS MODELS

25/100 ✓ Peer-reviewed Risk factors Business Excellence and Management

Key finding: The subscription based business model has significantly expanded beyond digital services, deeply penetrating the e-grocery and food delivery sectors. +2 more findings

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The head turning sign “outside the clinic walls” in patients with mild cognitive impairment and dementia

51/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer s Disease

Key finding: In MCI and dementia, the HTS is an ecologically valid non-canonical sign, frequently occurs in daily life too, associated with longer disease duration and spatial disorientation. +1 more finding

• Early Stage

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Psychometric properties, pragmatic screening cut‐offs, and feasibility of two Clock Drawing Test formats in older psychiatric outpatients: Associations with MMSE and HDS‐R

40/100 ✓ Peer-reviewed Cognitive tests and assessment Psychiatry and Clinical Neurosciences Reports

Key finding: Both CDT formats showed clinically useful psychometric properties and similar pragmatic cut‐offs in older psychiatric outpatients.

• Diagnosis

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Cognitive tasks for evoking the P300 event-related potential in Alzheimer's disease and mild cognitive impairment: A scoping review

36/100 ✓ Peer-reviewed Mild cognitive impairment International Journal of Psychophysiology

Key finding: Across studies, AD most consistently demonstrated prolonged P300 latency - most robustly in auditory oddball paradigms - whereas amplitude reductions were less reliable.

• Early Stage

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Atrophy signature for alpha-synuclein copathology in Alzheimer's disease

57/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Compared to CTR, both AD-αSAA- and AD-αSAA+ showed widespread cortical thinning. +2 more findings

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ADAM10 y su implicación en la enfermedad de Alzheimer

27/100 ✓ Peer-reviewed Genetics Neurología

Key finding: La estimulación de ADAM10 como diana terapéutica plantea posibilidades de desarrollo a través de varios componentes y medidas como el ejercicio físico, pero hasta ahora hay un solo ensayo clínico (positivo) con el retinoide acitretino. +4 more findings

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Sodium channel blockers are associated with reduced dementia risk in late-onset unexplained epilepsy

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's medRxiv

Key finding: Using data from over 75 million adults aged 55 years or older, we found that sodium channel blockers were associated with a 27% lower hazard of incident all-cause dementia (hazard ratio = 0.73, 95% confidence interval 0.61- 0.88) and 34% lower hazard of Alzheimer's disease (hazard ratio = 0.66, 0.49 -0.88), compared with levetiracetam/brivaracetam. +2 more findings

• Risk Factors
• Prevention

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Oral health, genetic susceptibility, and risk of dementia: a prospective cohort study of UK Biobank

57/100 ✓ Peer-reviewed Long-term cohort studies GeroScience

Key finding: Painful gums (HR 1.26, 95% CI 1.12-1.42) and denture use (HR 1.20, 95% CI 1.13-1.26) were associated with higher ACD risk, with comparable associations observed for AD and VaD. +4 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons and Converging Insights from Alternative Hypothesis

26/100 ✓ Peer-reviewed Genetics International Journal of Drug Delivery Technology

Key finding: Alzheimer disease is characterized by gradual and progressive neurodegeneration caused by neuronal cell death. +4 more findings

• Brain Biology
• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source

Plasma ApoE proteotyping for ApoE ε4 stratification in the anti-amyloid therapies era

61/100 ✓ Peer-reviewed Genetics Alzheimer's research & therapy

Key finding: The ratio showed excellent separation across genotypes in our cohort. +4 more findings

• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source

CNS-selective plasma p-tau217 accurately captures Alzheimer's disease pathology and progression

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv : the preprint server for health sciences

Key finding: Furthermore, the CNS-selective biomarker demonstrated more robust prediction of future clinical progression in individuals followed for up to two decades. +1 more finding

• Biomarkers
• Brain Biology

Scored 23 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Spatial Reorganization and Governance Synergy: Innovative Practices for Strengthening County-Level Wealth-Creating Industries—A Case Study of the Huameidani Area

26/100 ✓ Peer-reviewed Risk factors Nurture

Key finding: This article takes the "Hua Meida Ni" rural revitalization demonstration area in Qingdao West Coast New Area as a case study, systematically analyzing its "three-in-one" model of integrated integration, market-oriented operation, and diversified expansion. +4 more findings

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Advanced glycation end-products in the pathogenesis of Alzheimer’s disease: a review

27/100 ✓ Peer-reviewed Disease mechanisms Psychiatria i Psychologia Kliniczna

Key finding: Their presence has been demonstrated in both senile plaques and neurofibrillary tangles.

• Brain Biology

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The oscillatory biology of sleep: Linkage to dementia

47/100 ✓ Peer-reviewed Risk factors Science

Key finding: During sleep, the major neuromodulators-norepinephrine, acetylcholine, serotonin, and dopamine-exhibit synchronized fluctuations with a periodicity of ~50 seconds. +4 more findings

• Risk Factors
• Lifestyle

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Mapping U.S. POINTER Cognitive-Slope Gains Onto Predicted Clinical Progression: An External-Cohort Translation Analysis With Exploratory Economic Thresholds

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics medRxiv

Key finding: POINTER reported a modest structured-versus-self-guided difference in the annual rate of global cognitive change. +4 more findings

• Policy

Scored 52 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Plasma p-tau217, p-tau181, and Aβ42 predict amyloid PET positivity in cognitively unimpaired adults

71/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: Plasma p-tau217 showed the strongest individual association with Aβ PET status (area under the curve [AUC], 0.85). +4 more findings

• Biomarkers
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source